Method and apparatus for detecting vulnerable atherosclerotic plaque
First Claim
1. A method of detecting along a vessel wall an atherosclerotic plaque at risk of reducing fluid flow within said vessel, the method comprising determining whether said plaque or a region thereof exhibits an elevated temperature compared to the temperature of at least one adjacent vessel wall site.
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Accused Products
Abstract
Methods and devices are disclosed for detecting vulnerable atherosclerotic plaque, or plaque at risk of reducing blood flow in a vessel, by identifying a region of elevated temperature along a living vessel wall. The disclosure that human atherosclerotic plaque with measurable temperature heterogeneity has the morphological characteristics of plaque that is likely to ulcerate provides a new and sensitive technique for detecting and treating these dangerous plaques before myocardial infarction and its consequences occur. The disclosed methods are advantageous over conventional plaque detection techniques because they are capable of differentiating between those plaques that are at great risk of rupture, fissure, or ulceration, and consequent thrombosis and occlusion of the artery, and those that are not presently at risk. Infrared heat-sensing catheters useful for identifying potentially fatal arterial plaques in patients with disease of the coronary or other arteries are also described. In some embodiments a coherent infrared fiber optic bundle is employed to radially and longitudinally explore a luminal wall to identify inflamed, heat-producing, atherosclerotic plaque. Certain other methods and devices are disclosed which are particularly suited for non-invasively identifying and then monitoring the progression or amelioration of an inflamed plaque in a patient, and for monitoring for onset of inflammation in an implanted arteriovenous graft. Also disclosed are thermocouple basket catheters and thermistor basket catheters which are also capable of detecting temperature heterogeneity along a vessel wall.
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Citations
13 Claims
- 1. A method of detecting along a vessel wall an atherosclerotic plaque at risk of reducing fluid flow within said vessel, the method comprising determining whether said plaque or a region thereof exhibits an elevated temperature compared to the temperature of at least one adjacent vessel wall site.
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2. A method of identifying an atherosclerotic plaque at risk of rupture or thrombosis in a living vessel, the method comprising measuring the temperature of at least two sites along the lumen wall of said vessel and detecting a temperature elevation of about 0.4 to 4°
- C. at one said site compared to the temperature of at least one other said site.
Specification