Apparatus and methods for the delivery of medicaments to the respiratory system

• US 6,615,824 B2
• Filed: 05/04/2001
• Issued: 09/09/2003
• Est. Priority Date: 05/05/2000
• Status: Expired due to Term

• Current Assignee: Novartis Pharma AG (Novartis Ag)
• Original Assignee: Aerogen, Inc. (Nektar Therapeutics)
• Inventors: Power, John S.
• Primary Examiner(s): Gartenberg, Ehud
• Assistant Examiner(s): Kokabi, Azadeh
• Application Number:
  US09/849,194
• Publication Number:
  US 20020002975A1
• Time in Patent Office: 858 Days
• Field of Search: 128/200.14, 128/200.21, 128/200.23, 128/200.16, 128/204.18, 128/204, 128/21, 128/202.22, 128/204.23, 128/202.27, 239/338, 239/102.2, 222/180
• US Class Current: 128/200.14
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 2209/082 Mounting brackets, arm supports for equipment

Abstract

An apparatus for delivery of a medicament to the respiratory system comprises a reservoir that is adapted to hold a liquid medicament that is to be delivered to a respiratory system. An aerosol generator is provided that is adapted to aerosolize the liquid medicament. A liquid supplier is used to deliver the liquid medicament from the reservoir to the aerosol generator. A connector is operably coupled to the aerosol generator and comprises a gas conduit having an inlet, and an outlet, and an aerosol supply conduit. The aerosol generator is configured to provide the aerosolized liquid medicament into the gas conduit through the aerosol supply conduit, and the gas conduit is adapted to pass gases to entrain the aerosolized liquid medicament.

Claims

1. An apparatus for delivery of a medicament to the respiratory system, the apparatus comprising:

a reservoir adapted to hold a liquid medicament that is to be delivered to a respiratory system;

an aerosol generator that is adapted to aerosolize the liquid medicament;

a liquid supplier adapted to deliver the liquid medicament from the reservoir to the aerosol generator, wherein the liquid supplier is releasably mounted to a housing of the aerosol generator with a plurality of fingers for snap-fit engagement; and

a connector to which the aerosol generator is operably connected, wherein the connector comprises a gas conduit having an inlet, an outlet, and an aerosol supply conduit, wherein the aerosol generator is configured to provide the aerosolized liquid medicament into the gas conduit through the aerosol supply conduit, and wherein the gas conduit is adapted to pass gases to entrain the aerosolized liquid medicament.

2. Apparatus as claimed in claim 1, wherein the aerosol supply conduit subtends an angle less than 90°

with the inlet side of the gas conduit.

3. Apparatus as claimed in claim 2, wherein the aerosol supply conduit subtends an angle of less than 80°

with the inlet side of the gas conduit.

4. Apparatus as claimed in claim 3, wherein the aerosol supply conduit subtends an angle of about 75°

with the inlet side of the gas conduit.

5. Apparatus as claimed in claim 1, wherein the connector is mounted to the aerosol generator housing at the aerosol supply conduit.

6. Apparatus as claimed in claim 1, wherein the outlet of the gas conduit at least partially tapers outwardly.

7. Apparatus as claimed in claim 1, wherein the gas conduit comprises an outlet connector that is adapted to connect the gas conduit to a respiratory system.

8. Apparatus as claimed in claim 7, wherein the outlet of the gas conduit tapers outwardly in a step-wise manner to define a female connection recess at the outlet.

9. Apparatus as claimed in claim 7, further comprising a respiratory conduit that is adapted to connect the outlet of the gas conduit to a respiratory system.

10. Apparatus as claimed in claim 9, wherein the respiratory conduit is mounted to the connector at the outlet of the gas conduit.

11. Apparatus as claimed in claim 10, wherein the respiratory conduit is releasably mounted to the connector at the outlet of the gas conduit.

12. Apparatus as claimed in claim 10, wherein the respiratory conduit is mounted to the connector by an interference fit between the respiratory conduit and the outlet of the gas conduit.

13. Apparatus as claimed in claim 9, wherein the respiratory conduit is selected from a group consisting of a mouthpiece, a face mask, and an intertracheal tube.

14. Apparatus as claimed in claim 1, wherein the gas conduit comprises an inlet connector that is adapted to connect the connector to a ventilator.

15. Apparatus as claimed in claim 14, wherein the gas conduit comprises a male protrusion, and the inlet connector is at least partially provided by the protrusion.

16. Apparatus as claimed in claim 14, wherein further comprising a ventilator conduit to connect the gas conduit to a ventilator.

17. Apparatus as claimed in claim 16, wherein the ventilator conduit is mounted to the inlet connector of the gas conduit.

18. Apparatus as claimed in claim 17, wherein the ventilator conduit is releasably mounted to the inlet connector of the gas conduit.

19. Apparatus as claimed in claim 17, wherein the ventilator conduit is mounted to the inlet connector by an interference fit between the ventilator conduit and the gas conduit.

20. Apparatus as claimed in claim 1, wherein the aerosol generator comprises a vibratable member having a plurality of apertures extending between a first surface and a second surface thereof.

21. Apparatus as claimed in claim 20, wherein the first surface is adapted to receive the liquid medicament from the liquid supplier.

22. Apparatus as claimed in claim 20, wherein the aerosol generator is configured to generate the aerosol at the second surface of the vibratable member.

23. Apparatus as claimed in claim 20, wherein the vibratable member is dome shaped in geometry.

24. Apparatus as claimed in claim 20, wherein the vibratable member comprises a piezoelectric element.

25. Apparatus for delivery of medicament to a respiratory system comprising:

a medication cup that is adapted to receive a liquid medicament to be delivered to a respiratory system;

an aerosol generator;

a housing in which the aerosol generator is disposed, wherein the housing is releasably coupled to the medication cup;

a liquid supplier that is adapted to deliver the liquid medicament from the cup to the aerosol generator, wherein the liquid supplier is releasably mounted to the aerosol generator housing with a plurality of fingers for snap-fit engagement; and

a connector that is adapted to receive aerosol generated by the aerosol generator is delivered.

26. Apparatus as claimed in claim 25, wherein the aerosol generator is displaced from the medication cup, and wherein the liquid supplier is adapted to deliver the liquid medicament between the cup and the aerosol generator.

27. Apparatus as claimed in claim 25, wherein the plurality of fingers are circumferentially spaced apart.

28. Apparatus as claimed in claim 25 wherein the aerosol generator housing comprises four fingers.

29. Apparatus as claimed in claim 25, wherein the liquid supplier defines an annular protruding neck.

30. Apparatus as claimed in claim 25, wherein the medication cup is sealingly mounted to the aerosol generator housing.

31. Apparatus as claimed in claim 30, wherein the aerosol generator housing comprises a skirt extending to sealingly engage the medication cup.

32. Apparatus as claimed in claim 31, wherein the skirt has an angled surface to sealingly engage a chamfered mouth of the medication cup.

33. Apparatus as claimed in claim 25, wherein the medication cup is releasably mounted to the aerosol generator housing by a screw-thread engagement.

34. Apparatus as claimed in claim 25, wherein the medication cup defines a reservoir for the liquid medicament, and further comprising a medication delivery tube extending from the reservoir, the liquid supplier being at least partially received within the delivery tube for delivery of the liquid medicament to the aerosol generator.

35. Apparatus as claimed in claim 34, wherein the delivery tube is provided by the medication cup.

36. Apparatus as claimed in claim 35, wherein the delivery tube is integral with the medication cup.

37. Apparatus as claimed in claim 35, wherein the delivery tube is attached to the medication cup.

38. Apparatus as claimed in claim 34, wherein the delivery tube has an inlet that is adapted to receive the liquid medicament from the reservoir.

39. Apparatus as claimed in claim 38, wherein the inlet includes a number of inlet slots which are circumferentially spaced-apart around the delivery tube.

40. Apparatus as claimed in claim 38, wherein a base of the reservoir at least partially slopes downwards towards the delivery tube.

41. Apparatus as claimed in claim 38, wherein at least part of the liquid supplier extends below the inlet.

42. Apparatus as claimed in claims 34, wherein the reservoir includes a refill port.

43. Apparatus as claimed in claim 42, wherein the refill port is provided in a base of the reservoir.

44. Apparatus as claimed in claim 43, further comprising a plug to selectively seal the refill port.

45. Apparatus as claimed in claim 34, wherein the reservoir comprises a central well from which the delivery tube extends.

46. Apparatus as claimed in claim 34, wherein the liquid supplier comprises a resilient member to reciprocate the liquid supplier in the delivery tube.

47. Apparatus as claimed in claim 46, wherein the resilient member is engagable with a free end of the delivery tube.

48. Apparatus as claimed in claim 46, wherein the resilient member comprises a spring.

49. Apparatus as claimed in claim 34, wherein the medication cup comprises at least one depth indicator to indicate the volume of liquid medicament in the reservoir.

50. Apparatus as claimed in claim 49, wherein the depth indicator comprises an internal marking on a wall of the medication cup.

51. Apparatus as claimed in claim 25, wherein the medication cup has a base that is adapted to hold the cup in an upright orientation when receiving the liquid medicament.

52. Apparatus as claimed in claim 51, wherein the base includes a support skirt extending from the base of the medication cup.

53. Apparatus for delivery of medicament to a respiratory system comprising:

a reservoir that is adapted to hold a liquid medicament to be delivered to a respiratory system;

an aerosol generator;

a housing for the aerosol generator;

a liquid supplier that is adapted to deliver the liquid medicament from the reservoir to the aerosol generator, wherein the liquid supplier is releasably mounted to the aerosol generator housing with a plurality of fingers for snap-fit engagement; and

a connector through which aerosol generated by the aerosol generator is delivered;

wherein the aerosol generator housing includes a signal interface that is configured to receive control signals to control the operation of the aerosol generator.

54. Apparatus as claimed in claim 53, further comprising a controller to control the operation of the aerosol generator, the controller being connectable to the signal interface.

55. Apparatus as claimed in claim 54, wherein the controller comprises control means having an on-board power source.

56. Apparatus as claimed in claim 55, wherein the power source is a battery.

57. Apparatus as claimed in claim 56, wherein the battery is rechargeable.

58. Apparatus as claimed in claim 54, wherein the controller includes a power connector, the power connector being connectable to a remote power source.

59. Apparatus as claimed in claim 58, wherein the power connector comprises a ventilator power connection lead for connection to a ventilator power source.

60. Apparatus as claimed in claim 59 wherein the power connection lead is detachable from a socket in the control means.

61. Apparatus as claimed in claim 58, wherein the power connector comprises a main power connection lead for connection to a main power source.

64. Apparatus as claimed in claim 54, wherein the controller comprises user interface to selectively control the operation of the aerosol generator.

65. Apparatus as claimed in claim 64, wherein the user interface is remote from the aerosol generator housing.

66. Apparatus as claimed in claim 65, wherein the user interface means comprises a reset switch.

67. Apparatus as claimed in claim 64, wherein the user interface comprises an on/off switch.

68. Apparatus as claimed in claims 54, wherein the controller comprises status indication means to indicate the operational state of the aerosol generator.

69. Apparatus as claimed in claim 68, wherein the status indication means comprises at least one visual indicator.

70. Apparatus as claimed in claim 69, wherein the status indication means comprises two light emitting diodes, one to indicate an active state of operation of the aerosol generator, and the other to indicate a rest state of the aerosol generator.

71. Apparatus as claimed in claim 54, wherein the controller comprises a housing having a support to receive a mounting device.

72. Apparatus as claimed in claim 71, wherein the support comprises a recess in the housing for receiving a mounting device.

73. Apparatus as claimed in claim 72, wherein the support comprises at least one ledge overhanging the recess for engagement of a mounting device in the recess.

74. Apparatus as claimed in claim 73, wherein the support comprises two ledges on opposite sides of the recess.

75. Apparatus as claimed in claim 71, further comprising a mounting device to support the controller.

76. Apparatus as claimed in claim 75, wherein the mounting device comprises means for attaching the mounting device to a support;

and hook means for supporting the control housing, the hook means being configured to define a plurality of support surfaces for supporting the control housing in an upright configuration.

77. Apparatus as claimed in claim 76, wherein the support surfaces each comprise a lip protruding from a main body of the mounting device.

78. Apparatus as claimed in claim 77, wherein the lip is engagable in the recess in the housing to support the control means.

79. Apparatus as claimed in claim 76, wherein the hook means defines four support surfaces.

80. Apparatus as claimed in claim 79, wherein each support surface is substantially perpendicular to an adjacent support surface.

81. Apparatus as claimed in claim 76, wherein the attachment means is releasable.

82. Apparatus as claimed in claim 76, wherein the attachment means comprises a clamp.

83. Apparatus as claimed in any of claim 76, wherein the attachment means comprises a clip.

84. Apparatus as claimed in claim 76, wherein the hook means is movable relative to the attachment means to selectively disassociate the hook means from the attachment means.

85. A device as claimed in claim 84, wherein the attachment means defines a groove in which the hook means is slidable to selectively disassociate the hook means from the attachment means.

62. Apparatus as claimed in any 54, wherein the controller comprises a timer to automatically switch the aerosol generator between an active state and a rest state.

63. Apparatus as claimed in claim 62, wherein the timer is selectively programmable.

86. Apparatus for delivery of medicament to the respiratory system comprising:

a medication cup that is adapted to hold a liquid medication to be delivered to a respiratory system;

an aerosol generator;

a housing for the aerosol generator;

a liquid supplier that is adapted to deliver the liquid medicament from the cup to the aerosol generator; and

a connector through which aerosol generated by the aerosol generator is delivered,

wherein the liquid supplier is releasably mounted to the generator housing with a plurality of fingers for snap-fit engagement.

87. Apparatus for delivery of medicament to the respiratory system comprising:

a medication cup that is adapted to hold a liquid medication to be delivered to a respiratory system;

an aerosol generator;

a housing for the aerosol generator;

a liquid supplier that is adapted to deliver the liquid medicament from the cup to the aerosol generator, wherein the liquid supplier is releasably mounted to the aerosol generator housing with a plurality of fingers for snap-fit engagement; and

a connector through which aerosol generated by the aerosol generator is delivered;

wherein the aerosol generator housing has signal connection means for connection to a control means to control the operation of the aerosol generator.

88. Apparatus for delivery of medicament to the respiratory system comprising:

a medication cup that is adapted to hold a liquid medication to be delivered to a respiratory system;

an aerosol generator;

a housing for the aerosol generator;

a liquid supplier that is adapted to deliver the liquid medicament from the cup to the aerosol generator, wherein the liquid supplier is releasably mounted to the aerosol generator housing with a plurality of fingers for snap-fit engagement; and

a connector through which aerosol generated by the aerosol generator is delivered,

wherein the medication cup is releasably mounted to the aerosol generator housing.