Radioactive compositions and methods of use thereof

• US 6,616,591 B1
• Filed: 12/08/1999
• Issued: 09/09/2003
• Est. Priority Date: 12/08/1999
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Wallace, Michael P., Teoh, Clifford
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): SZMAL, BRIAN SCOTT
• Application Number:
  US09/457,227
• Time in Patent Office: 1,371 Days
• Field of Search: 600/1-8, 424/1.25, 424/1.33, 424/1.29, 524/916, 252/625, 252/634, 252/315.01, 514/944, 514/44
• US Class Current: 600/3
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61L 2300/44 Radioisotopes, radionuclides
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61N 2005/1019 Sources therefor
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

This relates to a composition for forming a radioactive material suitable for use in medicinal purposes. The invention relates to radioactive polymeric materials and radioactive vaso-occlusive devices. The invention also relates to radioactive, biodegradable occlusive agents which may be made from a precursor composition containing at least one biodegradable, polymeric component and at least one radioactive material. The occlusive agent may further include bioactive materials and/or known vaso-occlusive devices.

Claims

1. A vaso-occlusive composition comprising a biodegradable polymeric component and at least one radioactive material.

2. The composition of claim 1, wherein the radioactive material is dispersed throughout the polymeric component.

3. The composition of claim 1, wherein the radioactive material is fluoroscopically visible in situ.

4. The composition of claim 1, wherein the radioactive material is bioactive.

5. The composition of claim 1, wherein the biodegradable polymeric component is a biodegradable polyester.

6. The composition of claim 5, wherein the biodegradable polyesters are selected from polyglycolic acids, polylactic acids, and their copolymers.

7. The composition of claim 1, further comprising a biologically active material.

8. A solid vaso-occlusive mass comprising a radioactive material and a biodegradable, polyester polymer selected from the group consisting of polyglycolic acids, polylactic acids and their copolymers, and wherein the radioactive material is deposited onto the surface of the polymeric component.

9. The occlusive mass of claim 8, further comprising a bioactive material.

10. The occlusive mass of claim 9, wherein bioactive material is selected from the group consisting of collagen, fibrinogen, vitronectin, plasma proteins, growth factors, synthetic peptides of these and other proteins having attached RGD (arginine-glycine-aspartic acid) residues at one or both termini, cell adhesion peptides, oligonucleotides, full or partial DNA constructs, natural or synthetic phospholipids, a polymers with phosphorylcholine functionality, and polynucleotide sequences encoding peptides involved in wound healing or promoting cellular attachment.