System for correction of a biological fluid

• US 6,616,623 B1
• Filed: 10/04/1999
• Issued: 09/09/2003
• Est. Priority Date: 07/02/1997
• Status: Expired due to Fees

• Current Assignee: Idializa, Ltd.
• Original Assignee: Idializa, Ltd.
• Inventors: Kutushov, Michael
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): DEAK, LESLIE R
• Application Number:
  US09/411,375
• Time in Patent Office: 1,436 Days
• Field of Search: 604/4.01, 604/5.01, 604/5.02, 604/5.03, 604/5.04, 604/8, 604/9, 604/10, 604/6.09, 210/222, 210/223, 210/695
• US Class Current: 604/6.09
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3618 Magnetic separation
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: B03C 1/01 by addition of magnetic adjuvants
• CPC Class Codes: B03C 1/032 Matrix cleaning systems
• CPC Class Codes: B03C 1/0332 using permanent magnets
• CPC Class Codes: B03C 1/288 disposed at the outer circumference of a recipient
• CPC Class Codes: B03C 2201/18 Magnetic separation whereby the particles are suspended in a liquid
• CPC Class Codes: B03C 2201/26 for use in medical applications

Abstract

A system is presented for correction of a patient'"'"'s biological fluid, such as his blood, lymph or spinal fluid, containing various low-, medium- and high-molecular toxins. The system comprises an extracorporeal flow line in the form of a flexible tube interconnected between outlet and inlet means attached to appropriate location(s) on a patient'"'"'s body. A small amount of the biological fluid, i.e., substantially not exceeding 100 ml, substantially continuously flows through the tube, and is mixed with magneto-conductive particles capable of adsorbing the various toxins. An obtained mixture of the biological fluid with the particles passes through a magnetic field region, and substantially all of the magneto-conductive particles are retained therein. Particle-free biological fluid is then returned into the patient'"'"'s body through the inlet means.

Claims

1. A system for correcting a patient'"'"'s biological fluid containing various low-, medium- and high-molecular toxins by interaction of the biological fluid with magneto-conductive particles, the system comprising:

(i) an outlet means for attaching to the patient'"'"'s body for substantially continuously withdrawing therefrom the biological fluid containing the various toxins;

(ii) an inlet means for attaching to the patient'"'"'s body for returning corrected biological fluid back into the patient'"'"'s body;

(iii) an extracorporeal flow line interconnected between the outlet and inlet means for passing therethrough, in a substantially continuous flow, a predetermined amount of the biological fluid substantially not exceeding 100 ml, the flow line comprising first and second flexible tubes and a sealed vessel with a plurality of magneto-conductive particles within its bottom region, the first tube being connected between the outlet means and the particles, the second tube being connected between the inlet means and a top region of the vessel, said magneto-conductive particles being capable of absorbing the toxins in the biological fluid, whereby said predetermined amount of biological fluid becomes mixed with said magneto-conductive particles to obtain a mixture of the biological fluid with said particles;

(iv) a magnetic mechanism comprising a magnetic field source producing a magnetic field region within a flow of said mixture for retaining said magneto-conductive particles in said region from a flow of particle-free biological fluid to be returned into the patient'"'"'s body through the inlet means; and

(v) a pump assembly that provides the biological fluid flow through the flow line with a predetermined speed value.

2. The system according to claim 1, wherein said biological fluid to be treated is the patient'"'"'s blood, the outlet and inlet means being adapted to be coupled to an artery and vein of the patient, respectively, to thereby enable the blood to flow through the flow line with its usual velocity of circulation within the patient'"'"'s body.

3. The system according to claim 1, wherein said biological fluid to be treated is the patient'"'"'s blood, the outlet and inlet means being adapted to be coupled to a vein of the patient.

4. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the outlet means including a catheter adapted to be installed in the patient'"'"'s large pectoral lympheduct at the place of its falling into the cava, the inlet means including a catheter adapted to be inserted into a jugular vein.

5. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the outlet means including a catheter adapted to be installed into the patient'"'"'s large pectoral lympheduct at the place of its falling into the cava, the inlet means including a catheter adapted to be inserted into a cubital vein.

6. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the outlet and inlet means comprising a two-channel needle adapted to be inserted to the patient'"'"'s large pectoral lympheduct at the place of its falling into the cava.

7. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the outlet means including a needle adapted to be inserted into the cistern through the cervical opening, and the inlet means including a needle adapted to be inserted between the 4^th and the 5^th lumbar vertebrae.

8. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the outlet and inlet means comprising a two-channel needle adapted to be inserted into the cistern through the cervical opening.

9. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the outlet and inlet means comprising a two-channel needle adapted to be inserted into the patient'"'"'s spine between the 4^th and the 5^th lumbar vertebrae.

10. The system according to claim 1, wherein the magnetic mechanism also comprises an adhering means accommodated inside the flow line for adhering thereon the magneto-conductive particles, said adhering means being made of a paramagnetic or ferromagnetic material and creating the magnetic field region at least in the direction transverse to the flow direction of the mixture.

11. The system according to claim 10, wherein the adhering means includes a paramagnetic or ferromagnetic filler element installed inside the flow line within the magnetic field region.

12. The system according to claim 11, wherein the filler is in the form of a loosely laid wire.

13. The system according to claim 12, wherein said loosely laid wire is in the form of a barbed wire.

14. The system according to claim 12, wherein the wire has a varying diameter thereof and a varying laying density within the magnetic field region.

15. The system according to claim 10, wherein the magnetic field source and the adhering means are constituted by at least one permanent magnet accommodated inside the flow line.

16. The system according to claim 1, wherein the magnetic field source comprises at least one permanent magnet mounted outside the flow line and proximate thereto.

17. The system according to claim 16, wherein said at least one permanent magnet is in the form of a substantially flat plate.

18. The system according to claim 16, wherein said at least one permanent magnet is ring-shaped for surrounding the flow line.

19. The system according to claim 16, wherein opposite poles of each magnet are connected by a cover plate formed of a magnetic soil material.

20. The system according to claim 1, wherein said magnetic mechanism also comprises a wire wound on an outer surface of the flow line within the magnetic field region.

21. The system according to claim 1, and also comprising a control means coupled to the flow line and to the magnetic mechanism for operating thereof.

22. The system according to claim 1, wherein said biological fluid to be corrected is the patient'"'"'s blood, the system also comprising a filtering means for removing water from the blood.

23. The system according to claim 22, wherein the filtering means includes at least one semipermeable membrane.

24. The system according to claim 22, wherein the filtering means includes adsorbent material formed of hydrolyzed starch polymer.

25. The system according to claim 22, wherein said filtering means is accommodated in the flow path of the biological fluid containing the various toxins.

26. The system according to claim 22, wherein said filtering means is accommodated in the flow path of the particle-free biological fluid.

27. The system according to claim 1, wherein the magneto-conductive particles have activated porous surfaces.

28. The system according to claim 27, wherein said particles are made of iron.

29. The system according to claim 27, wherein said particles are made of iron oxide.

30. The system according to claim 27, wherein said particles are made of carbon coated iron.

31. The system according to claim 27, wherein said particles are made of silicone coated iron.

32. The system according to claim 27, wherein said particles are made of aluminum coated iron.

33. The system according to claim 27, wherein said particles are made of dextran coated iron.

34. The system according to claim 27, wherein each of said magneto-conductive particles has a protective layer coating containing protein or the patient'"'"'s blood.

36. The system according to claim 20, wherein said flow line is in the form of a flexible tube.

35. A system, for correcting a patient'"'"'s biological fluid containing various low-, medium- and high-molecular toxins by interaction of the biological fluid with magneto-conductive particles, the system comprising:

(i) an outlet means for attaching to the patient'"'"'s body for substantially continuously withdrawing therefrom the biological fluid containing the various toxins;

(ii) an inlet means for attaching to the patient'"'"'s body for returning corrected biological fluid back into the patient'"'"'s body;

(iii) an extracorporeal flow line interconnected between the outlet and inlet means for passing therethrough, in a substantially continuous flow path, a predetermined amount of the biological fluid substantially not exceeding 100 ml, the extracorporeal flow line comprising a mixing means located in the flow path of the biological fluid containing the various toxins, said mixing means being adapted to thereby provide mixing of the biological fluid with a plurality of magneto-conductive particles capable of adsorbing said toxins for obtaining a mixture of the biological fluid with the magneto-conductive particles during operation of said system; and

(iv) a magnetic mechanism comprising a magnetic field source producing a magnetic field region within a flow of said mixture for retaining the magneto-conductive particles in said region from a flow of particle-free biological fluid to be returned into the patient'"'"'s body through the inlet means during operation of said system.

37. The system according to claim 35, and also comprising a vessel adapted to contain magneto-conductive particles, said vessel being coupled to the flow line through a pipe.

38. The system according to claim 37, wherein said vessel contains a suspension of said magneto-conductive particles.

39. The system according to claim 38, wherein the magneto-conductive particles have activated porous surfaces.

40. The system according to claim 39, wherein said particles are made of at least one of the following iron, iron oxide, carbon coated iron, silicone coated iron, aluminum coated iron, and dextran coated iron.

41. The system according to claim 39, wherein each of said magneto-conductive particles has a protective layer coating containing protein or the patient'"'"'s blood.

42. The system according to claim 35, and also comprising a feeding means adapted to substantially continuously feed the magneto-conductive particles into the flow line.

43. The system according to claim 42, wherein said feeding means comprises a pump coupled to the vessel for supplying air thereto so as to provide an excessive pressure within the vessel.

44. The system according to claim 35, and also comprising a pump assembly that provides the biological fluid flow through the flow line with a predetermined speed value.

45. The system according to claim 44, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the speed of circulation being about 1-10 ml/min.

46. The system according to claim 44, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the speed of circulation being about 1-30 ml/min.

47. The system according to claim 35, wherein said flow line has an inside region thereof adapted for location of the magneto-conductive particles therewithin so as to be in a flow path of the biological fluid containing the various toxins flowing towards the magnetic field region.

48. The system according to claim 35, wherein the mixing means comprises a multi-threaded worm mechanism.

49. The system according to claim 35, wherein the mixing means comprises a magnetic mechanism having displaceable opposite magnetic poles.

50. The system according to claim 35, wherein the magnetic mechanism also comprises an adhering means accommodated inside the flow line adapted to adhere thereon the magneto-conductive particles, said adhering means being made of a paramagnetic or ferromagnetic material and creating the magnetic field gradient at least in the direction transverse to the flow direction of the mixture.

51. The system according to claim 35, wherein the magnetic field source comprises at least one permanent magnet mounted outside the flow line and proximate thereto.

52. The system according to claim 35, comprising at least one permanent magnet accommodated inside the flow line, said at least one permanent magnet serving as the magnetic field source and as an adhering means adapted for adhering thereon the magneto-conductive particles.

53. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s blood, the system also comprising a filtering means for removing water from the blood.

54. The system according to claim 35, wherein said biological fluid to be treated is the patient'"'"'s blood, the outlet and inlet means being adapted to be coupled to an artery and vein of the patient, respectively, to thereby enable the blood to flow through the flow line with its usual velocity of circulation within the patient'"'"'s body.

55. The system according to claim 35, wherein said biological fluid to be treated is the patient'"'"'s blood, the outlet and inlet means being adapted to be coupled to a vein of the patient.

56. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the outlet means including a catheter adapted to be installed in the large pectoral lympheduct at the place of its falling into the cava, the inlet means including a catheter adapted to be inserted into a jugular vein.

57. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the outlet means including a catheter adapted to be installed into the large pectoral lympheduct at the place of its falling into the cava, the inlet means including a catheter adapted to be inserted into a cubital vein.

58. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s lymph, the outlet and inlet means comprising a two-channel needle adapted to be inserted to the large pectoral lympheduct at the place of its falling into the cava.

59. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the outlet means including a needle adapted to be inserted into the cistern through the cervical opening, and the inlet means including a needle adapted to be inserted between the 4^th and the 5^th lumbar vertebrae.

60. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the outlet and inlet means comprising a two-channel needle adapted to be inserted into the cistern through the cervical opening.

61. The system according to claim 35, wherein said biological fluid to be corrected is the patient'"'"'s spinal fluid, the outlet and inlet means comprising a two-channel needle adapted to be inserted into the patient'"'"'s spine between the 4^th and the 5^th lumbar vertebrae.

62. The system according to claim 35, wherein said magnetic mechanism also comprises a wire wound on an outer surface of the flow line within the magnetic field region.

63. The system according to claim 35, and also comprising a control means coupled to the flow line and to the magnetic mechanism for operating thereof.