Systems and method for controlling renovascular perfusion

• US 6,616,624 B1
• Filed: 10/30/2000
• Issued: 09/09/2003
• Est. Priority Date: 10/30/2000
• Status: Active Grant

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Kieval, Robert S.
• Primary Examiner(s): Basichas, Alfred
• Application Number:
  US09/702,089
• Time in Patent Office: 1,044 Days
• Field of Search: 604/8, 600/485, 600/486, 600/505, 600/201, 600/202, 600/203, 600/204
• US Class Current: 604/8
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

Devices, systems and methods by which the real or apparent renovascular perfusion and intrarenal pressure may be selectively and controllably increased. By selectively and controllably increasing renovascular perfusion and interstitial hydrostatic pressure when the heart is unable to pump sufficient blood or when renal perfusion is suboptimal, the present invention reduces or reverses neurohormonal activation and fluid retention, and thereby minimizes their deleterious effects on the heart, vasculature, kidneys and other body systems.

Claims

1. A method of treating a patient comprising the steps of:

providing a blood perfusion modification device;

positioning the blood perfusion modification device in the patient'"'"'s renovascular circulation or immediately adjacent thereto;

providing a sensor;

positioning the sensor in a renal artery or upstream thereof to generate a signal indicative of a need to modify renal perfusion; and

activating, deactivating or otherwise modifying the blood perfusion modification device as a function of the sensor signal to cause an increase in renal perfusion.

2. A method as in claim 1, wherein the modification device comprises a flow regulator, and wherein the flow regulator is positioned in a renal vein or immediately downstream thereof to create back pressure in the renovascular circulation.

3. A method as in claim 1, wherein the modification device comprises a flow redirector, and wherein the flow redirector is positioned downstream of a renal artery to redirect blood flow to the renal artery.

4. A method as in claim 3, wherein the flow redirector is positioned in a descending aorta downstream of the renal artery to redirect blood flow to the renal artery.

5. A method as in claim 3, wherein the flow redirector is positioned in a common iliac artery downstream of the renal artery to redirect blood flow to the renal artery.

6. A method as in claim 1, wherein the modification device comprises a pump, and wherein the pump is positioned upstream of a renal artery to supplement blood flow therein.

7. A method as in claim 1, wherein the modification device comprises a pump, and wherein the pump is positioned downstream of a renal vein to reduce blood flow or causes back flow therein.

8. A method as in claim 1, wherein the modification device comprises a drug delivery device, and wherein the drug delivery device is positioned patient'"'"'s renovascular circulation or immediately adjacent thereto.

9. A method as in claim 1, wherein the modification device is positioned intravascularly.

10. A method as in claim 1, wherein the modification device is positioned extravascularly.

11. A method as in claim 1, wherein the sensor generates a signal indicative of pressure, and wherein the modification device is activated, deactivated or otherwise modified when the pressure falls below or rises above a predetermined threshold pressure.

12. A method as in claim 1, wherein the sensor generates a signal indicative of urine production, and wherein the modification device is activated, deactivated or otherwise modified when the urine production falls below or rises above a predetermined threshold value.

13. A method of treating a patient having a clinical condition, the method comprising the steps of:

diagnosing or monitoring the clinical condition or a sign thereof;

providing a blood perfusion modification device;

positioning the blood perfusion modification device in the patient'"'"'s renovascular circulation or immediately adjacent thereto; and

activating, deactivating or otherwise modifying the blood perfusion modification device to cause an increase in renal perfusion to thereby treat the clinical condition.

14. A method as in claim 13, further comprising the steps of:

providing a sensor;

positioning the sensor in, on or adjacent the patient to generate a signal indicative of a need to modify renal perfusion; and

wherein the step of activating, deactivating or otherwise modifying the blood perfusion modification device is performed as a function of the sensor signal to cause an increase in renal perfusion to thereby treat the clinical condition.

15. A method as in claim 14, wherein the sensor is positioned upstream of the modification device.

16. A method as in claim 13, wherein the clinical condition comprises congestive heart failure, and wherein the diagnosing or monitoring step comprises diagnosing or monitoring the congestive heart failure condition.

17. A method as in claim 13, wherein the clinical condition comprises hypertension, and wherein the diagnosing or monitoring step comprises diagnosing or monitoring the hypertension condition.

18. A method as in claim 13, wherein the clinical condition comprises renal failure, and wherein the diagnosing or monitoring step comprises diagnosing or monitoring the renal failure.

19. A method as in claim 13, wherein the clinical condition comprises a cardiovascular or renal abnormality, and wherein the diagnosing or monitoring step comprises diagnosing or monitoring the cardiovascular or renal abnormality.

20. A method of treating a patient comprising the steps of:

providing a blood perfusion modification device;

positioning the blood perfusion modification device in the patient'"'"'s renovascular circulation or immediately adjacent thereto;

providing a sensor;

positioning the sensor in a renal artery or upstream thereof to generate a signal indicative of a need to modify renal perfusion; and

activating, deactivating or otherwise modifying the blood perfusion modification device as a function of the sensor signal to cause an increase in renal perfusion,

wherein the sensor generates a signal indicative of urine production, and wherein the modification device is activated, deactivated or otherwise modified when the urine production falls below or rises above a predetermined threshold value.

21. A method as in claim 20, wherein the sensor is positioned upstream of the modification device.

22. A method as in claim 20, wherein the modification device comprises a flow regulator, and wherein the flow regulator is positioned in a renal vein or immediately downstream thereof to create back pressure in the renovascular circulation.

23. A method as in claim 20, wherein the modification device comprises a flow redirector, and wherein the flow redirector is positioned downstream of a renal artery to redirect blood flow to the renal artery.

24. A method as in claim 23, wherein the flow redirector is positioned in a descending aorta downstream of the renal artery to redirect blood flow to the renal artery.

25. A method as in claim 23, wherein the flow redirector is positioned in a common iliac artery downstream of the renal artery to redirect blood flow to the renal artery.

26. A method as in claim 23, wherein the modification device comprises a pump, and wherein the pump is positioned upstream of a renal artery to supplement blood flow therein.

27. A method as in claim 20, wherein the modification device comprises a pump, and wherein the pump is positioned downstream of a renal vein to reduce blood flow or causes back flow therein.

28. A method as in claim 20, wherein the modification device comprises a drug delivery device, and wherein the drug delivery device is positioned patient'"'"'s renovascular circulation or immediately adjacent thereto.

29. A method as in claim 20, wherein the modification device is positioned intravascularly.

30. A method as in claim 20, wherein the modification device is positioned extravascularly.