Triblock copolymer hollow particles for agent delivery by permeability change
First Claim
1. A composition for delivery of an agent comprising a hollow particle that undergoes a change in permeability to the agent in response to a stimulus, wherein the hollow particle is formed of a copolymer comprising a stimulus responsive triblock ABA or BAB copolymer that is amphiphilic, wherein A is a hydrophilic block and B is a hydrophobic block.
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Abstract
Polymeric hollow particles for delivery of an agent are provided that change permeability in response to a change in an external stimulus such as pH, temperature, light, ionic strength, electric field, magnetic field and/or solvent composition. The particles can have a shell formed of an amphiphilic triblock ABA or BAB copolymer, where A is a hydrophilic block and B is a hydrophobic block. Low permeability particles with a reversibly permeable shell expand and increase permeability in response to a stimulus so that an active agent such as a therapeutic, prophylactic or diagnostic agent can be introduced. Removing the stimulus allows the particles to return to a low permeability state to form particles loaded with the active agent. Surfaces of the particles can be modified with specific ligands that allow the particles to be directed to a specific target via molecular recognition.
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Citations
18 Claims
- 1. A composition for delivery of an agent comprising a hollow particle that undergoes a change in permeability to the agent in response to a stimulus, wherein the hollow particle is formed of a copolymer comprising a stimulus responsive triblock ABA or BAB copolymer that is amphiphilic, wherein A is a hydrophilic block and B is a hydrophobic block.
- 11. A method for manufacture of a composition for delivery of an agent comprising encapsulating the agent into a hollow particle that undergoes a change in permeability to the agent in response to a stimulus, wherein the hollow particle is formed of a copolymer comprising a stimulus responsive triblock ABA or BAB copolymer that is amphiphilic, wherein A is a hydrophilic block and B is a hydrophobic block.
Specification