Thermal imaging of fat and muscle using a simultaneous phase and magnitude double echo sequence

• US 6,618,608 B1
• Filed: 10/24/2000
• Issued: 09/09/2003
• Est. Priority Date: 11/30/1999
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: Txsonics-Limited
• Inventors: Cline, Harvey E., Watkins, Ronald D.
• Primary Examiner(s): PAIK, SANG YEOP
• Application Number:
  US09/696,624
• Time in Patent Office: 1,050 Days
• Field of Search: 600/407, 600/409, 600/410, 600/412, 600/437, 600/438, 600/549, 324/307, 324/308, 324/309, 324/315
• US Class Current: 600/412
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/4828 Resolving the MR signals of different chemical species, e.g. water-fat imaging

Abstract

A method for magnetic resonance imaging includes applying a first two echo gradient echo sequence to a tissue region, the first two echo sequence generating a first echo and a subsequent second echo. A second two echo gradient echo sequence is applied after heating the tissue region, the second two echo sequence generating a third echo and a subsequent fourth echo. A magnitude difference between the third echo and the first echo is measured and correlated to a temperature shift for fat tissue, and a phase difference between the fourth echo and the second echo is measured and correlated to a temperature shift for water-based tissue. A thermal image is generated of the tissue region based upon the temperature shift for both fat and water-based tissue.

Claims

1. A method for thermal magnetic resonance imaging, comprising:

generating a first two echo sequence before heating a tissue region within a patient, the first two echo sequence having a first echo optimized for temperature contrast from fat tissue and a second echo optimized for temperature contrast from water-based tissue;

heating the tissue region;

generating a second two echo sequence after heating the tissue region, the second two echo sequence having a third echo optimized for temperature contrast from fat tissue and a fourth echo optimized for temperature contrast from water-based tissue;

comparing the first echo to the third echo to obtain a temperature shift in fat tissue; and

comparing the second echo to the fourth echo to obtain a temperature shift in water-based tissue.

2. The method of claim 1, wherein the step of comparing the first echo to the third echo comprises:

measuring a magnitude difference between the third echo and the first echo; and

correlating the magnitude difference to the temperature shift in fat tissue.

3. The method of claim 1, wherein the step of comparing the second echo to the fourth echo comprises:

measuring a phase difference between the fourth echo and the second echo; and

correlating the phase difference to the temperature shift in water-based tissue.

4. The method of claim 1, further comprising generating a thermal image of the tissue region based upon the temperature shifts in fat and water-based tissue.

5. The method of claim 1, wherein the step of generating a first two echo sequence comprises using a gradient echo sequence to generate the first and second echoes.

6. The method of claim 1, wherein the step of generating a second two echo sequence comprises using a gradient echo sequence to generate the third and fourth echoes.

7. The method of claim 1, wherein the step of generating a first two echo sequence comprises generating a single radio frequency (RF) excitation pulse to generate both the first echo and the second echo.

8. The method of claim 7, wherein the RF excitation pulse is configured for generating a low angle flip of less than about ninety degrees.

9. The method of claim 1, further comprising focusing ultrasonic energy towards the tissue region between the steps of generating the first and second two echo sequences.

10. A method for thermal magnetic resonance imaging, comprising:

generating a first two echo sequence before heating a tissue region within a patient, the first two echo sequence having a first echo optimized for temperature contrast from fat tissue and a second echo optimized for temperature contrast from water-based tissue;

directing thermal energy towards the tissue region;

generating a second two echo sequence after directing the thermal energy towards the tissue region, the second two echo sequence having a third echo optimized for temperature contrast from fat tissue and a fourth echo optimized for temperature contrast from water-based tissue;

comparing the third echo and the first echo to obtain a first difference;

comparing the fourth echo and the second echo to obtain a second difference; and

combining a complex difference between the first difference and the second difference to identify a location of the thermal energy.

11. The method of claim 10, further comprising comparing the complex difference with at least one of the first difference and the second difference to identify whether the location of the thermal energy is within fat tissue or muscle tissue.

12. The method of claim 10, wherein the first difference comprises a magnitude difference between the third echo and the first echo.

13. The method of claim 12, further comprising correlating the magnitude difference to a temperature shift in fat tissue.

14. The method of claim 10, wherein the second difference comprises a phase difference between the fourth echo and the second echo.

15. The method of claim 14, further comprising correlating the phase difference to a temperature shift in water-based tissue.

16. A method for thermal magnetic resonance imaging, comprising:

applying a first two echo gradient echo sequence to a tissue region of a patient, the first two echo sequence generating a first echo and a subsequent second echo within the tissue region;

directing thermal energy towards the tissue region;

applying a second two echo gradient echo sequence after directing the thermal energy towards the tissue region, the second two echo sequence generating a third echo and a subsequent fourth echo within the tissue region;

comparing the first echo to the third echo to obtain temperature shift data attributable substantially to fat tissue within the tissue region; and

comparing the second echo to the fourth echo to obtain temperature shift data attributable substantially to water-based tissue within the tissue region.

17. The method of claim 16, wherein the step of comparing the first echo to the third echo comprises:

measuring a magnitude difference between the third echo and the first echo; and

correlating the magnitude difference to the temperature shift for fat tissue.

18. The method of claim 16, wherein the step of comparing the second echo to the fourth echo comprises:

measuring a phase difference between the fourth echo and the second echo; and

correlating the phase difference to the temperature shift for water-based tissue.

19. The method of claim 16, further comprising generating a thermal image of the tissue region based upon the temperature shift data for both fat and water-based tissue.

20. The method of claim 16, further comprising combining a complex difference between the temperature shift data for the fat tissue and the water-based tissue to identify a location of the thermal energy.