Prophylactic and therapeutic monoclonal antibodies
First Claim
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1. A composition comprising a monoclonal antibody directed against a homolog of vaccinia L1R, a monoclonal antibody directed against a homolog of vaccinia A33R, and at least one monoclonal antibody directed against an antigen selected from the group consisting of vaccinia H3L, D8L, B5R, A27L and A17L.
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Abstract
In this application are described vaccinia monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of vaccinia virus infections in vitro and in vivo.
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Citations
14 Claims
- 1. A composition comprising a monoclonal antibody directed against a homolog of vaccinia L1R, a monoclonal antibody directed against a homolog of vaccinia A33R, and at least one monoclonal antibody directed against an antigen selected from the group consisting of vaccinia H3L, D8L, B5R, A27L and A17L.
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10. An anti-vaccinia composition, comprising a monoclonal antibody directed against a homolog of vaccinia A33R, a monoclonal antibody directed against a homolog of vaccinia L1R, and at least one monoclonal antibody directed against an antigen selected from the group consisting of homologs of vaccinia H3L, D8L, B5R, A27L and A17L, in an amount effective for inhibiting vaccinia virus infection, and a pharmaceutically acceptable carrier.
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14. A composition comprising a monoclonal antibody directed against vaccinia B5R, and a monoclonal antibody directed against vaccinia A27L.
Specification