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Method for the detection of cellular abnormalities using fourier transform infrared spectroscopy

  • US 6,620,621 B1
  • Filed: 11/03/1999
  • Issued: 09/16/2003
  • Est. Priority Date: 11/13/1995
  • Status: Expired due to Fees
First Claim
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1. A method for identifying a patient at high risk for dysplasia utilizing single cell infrared microspectroscopy, said method comprising;

  • (a) creating a reference set of absorption spectra from cervical cell samples taken from women having no history of dysplasia, each of said samples having a first cell exhibiting a first spectrum pattern and a second cell exhibiting a second spectrum pattern;

    (b) producing absorption data for a cervical cell sample acquired from said patient by directing a beam of infrared light at single cells in said cervical cell sample to produce absorption data for each of said single cells;

    (c) comparing said absorption data for said cervical cell sample acquired from said patient with said reference spectra, thereby generating comparison data;

    (d) generating scores for said absorption data using said comparison data;

    (e) creating frequency distribution profiles from said scores; and

    (f) detecting said high risk for dysplasia using said frequency distribution profiles.

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