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Ultra high throughput sampling and analysis systems and methods

  • US 6,620,625 B2
  • Filed: 12/28/2000
  • Issued: 09/16/2003
  • Est. Priority Date: 01/06/2000
  • Status: Expired due to Term
First Claim
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1. A method of sampling compounds into a microfluidic channel, comprising:

  • providing a plurality of different compounds reversibly immobilized on a first surface of a substrate;

    providing a capillary element having a microfluidic channel disposed therethrough, the capillary element having at least one open end, and a volume of solubilizing fluid present at the open end of the capillary element;

    moving the solubilizing fluid at the open end of the capillary element into contact with a first compound on the surface of the substrate;

    sensing when the solubilizing fluid contacts the surface of the substrate, the solubilizing fluid dissolving at least a portion of the first compound; and

    drawing at least a portion of the dissolved first compound into the capillary element.

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