Diffuse reflectance monitoring apparatus
First Claim
1. A device for performing non-invasive determination of a glucose concentration in tissue of a subject, the device comprising:
- an input element for emitting infrared radiation on the tissue of the subject, the input element adapted to emit radiation a multiple wavelengths and directing the multiple wavelengths of radiation to an input location;
an output element for detecting at least a portion of the radiation not absorbed by the tissue of the subject, wherein on a ray basis the radiation emitted by the input element enters the tissue at an entrance point and the radiation detected by the output element exits the skin at an exit point, and wherein the entrance point and the exit point for individual rays are separated by a distance in the range of 100 μ
m to 800 μ
m to preferentially collect radiation primarily reflected from deeper within the tissue by the output element; and
a spectroscopic analyzer for analyzing the non-absorbed radiation and determining the glucose concentration in the tissue of the subject.
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Accused Products
Abstract
An improved method and apparatus for diffuse reflectance spectroscopy. A specular control device is provided that can discriminate between diffusely reflected light that is reflected from selected depths or layers within the tissue. The specular control device permits a spectroscopic analyzer to receive the diffusely reflected light that is reflected from, for example, a first layer or depth within the tissue, while preventing the remaining diffusely reflected light from reaching the spectroscopic analyzer. Furthermore, the specular control device may prevent the specularly reflected light (e.g. surface reflected light) from reaching the spectroscopic analyzer.
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Citations
9 Claims
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1. A device for performing non-invasive determination of a glucose concentration in tissue of a subject, the device comprising:
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an input element for emitting infrared radiation on the tissue of the subject, the input element adapted to emit radiation a multiple wavelengths and directing the multiple wavelengths of radiation to an input location;
an output element for detecting at least a portion of the radiation not absorbed by the tissue of the subject, wherein on a ray basis the radiation emitted by the input element enters the tissue at an entrance point and the radiation detected by the output element exits the skin at an exit point, and wherein the entrance point and the exit point for individual rays are separated by a distance in the range of 100 μ
m to 800 μ
m to preferentially collect radiation primarily reflected from deeper within the tissue by the output element; and
a spectroscopic analyzer for analyzing the non-absorbed radiation and determining the glucose concentration in the tissue of the subject. - View Dependent Claims (2)
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3. A device for performing non-invasive determination of a glucose concentration in tissue of subject, the subject having tissue with an epidermis layer and a dermis layer, the device comprising:
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an input element for emitting infrared radiation to the tissue of the subject, the input element adapted to emit radiation at multiple wavelengths and directing the multiple wavelengths of radiation to an input location;
an output element for detecting at least a portion of the radiation reflected by the tissue of the subject, wherein the radiation emitted by the input element enters the tissue at an entrance point and the radiation detected by the output element exits the tissue at an exit point, and wherein the entrance point and the exit point are separated by a distance in the range of 100 μ
m to 800 μ
m; and
a spectroscopic analyzer for analyzing the non-absorbed radiation and determining the glucose concentration in the tissue of the subject. - View Dependent Claims (4)
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5. A device for performing non-invasive determination of a glucose concentration in the tissue of a subject having an epidermis layer and a dermis layer, the device comprising:
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an input element for emitting infrared radiation to the tissue of the subject, the input element adapted to emit radiation at multiple wavelengths and directing the multiple wavelengths of radiation to an input location;
an output element for detecting at least a portion of the radiation not absorbed by the tissue of the subject, wherein the radiation detected by the output element enters and exits the skin separated by a distance, and wherein the distance is in the range of 100 μ
m to 800 μ
m; and
a spectroscopic analyzer for analyzing the non-absorbed radiation and determining the glucose concentration in the tissue of the subject. - View Dependent Claims (6, 7)
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8. A device for performing non-invasive determination of a glucose concentration in the tissue of a subject, the subject having skin with an epidermis layer and a dermis layer, the device comprising:
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an input element for emitting near-infrared radiation on the skin of the subject;
an output element for detecting radiation not absorbed by the skin of the subject, wherein the radiation detected by the output element enters and exits the skin separated by a distance in the range of 100 μ
m to 800 μ
m, and wherein the distance is selected such that there is a preferential collection of radiation that has penetrated beyond the surface of the tissue; and
a spectroscopic analyzer f r analyzing the non-absorbed radiation and determining the glucose concentration of the subject. - View Dependent Claims (9)
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Specification