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Diffuse reflectance monitoring apparatus

  • US 6,622,033 B2
  • Filed: 03/28/2001
  • Issued: 09/16/2003
  • Est. Priority Date: 08/09/1995
  • Status: Expired due to Fees
First Claim
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1. A device for performing non-invasive determination of a glucose concentration in tissue of a subject, the device comprising:

  • an input element for emitting infrared radiation on the tissue of the subject, the input element adapted to emit radiation a multiple wavelengths and directing the multiple wavelengths of radiation to an input location;

    an output element for detecting at least a portion of the radiation not absorbed by the tissue of the subject, wherein on a ray basis the radiation emitted by the input element enters the tissue at an entrance point and the radiation detected by the output element exits the skin at an exit point, and wherein the entrance point and the exit point for individual rays are separated by a distance in the range of 100 μ

    m to 800 μ

    m to preferentially collect radiation primarily reflected from deeper within the tissue by the output element; and

    a spectroscopic analyzer for analyzing the non-absorbed radiation and determining the glucose concentration in the tissue of the subject.

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