Rebreathing circuit to set and stabilize end tidal and arterial PCO2 despite varying levels of minute ventilation

• US 6,622,725 B1
• Filed: 10/02/2000
• Issued: 09/23/2003
• Est. Priority Date: 03/31/2000
• Status: Expired due to Term

• Current Assignee: Thornhill Scientific Inc.
• Original Assignee: Alex Vesely, George Volgyesi, Hiroshi Sasano, Janet Tesler, Joseph A. Fisher
• Inventors: Fisher, Joseph A., Volgyesi, George, Sasano, Hiroshi, Tesler, Janet, Vesely, Alex
• Primary Examiner(s): Lo, Weilun
• Assistant Examiner(s): MITCHELL, TEENA KAY
• Application Number:
  US09/676,899
• Time in Patent Office: 1,086 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.22, 128/204.23, 128/204.26, 128/204.28, 128/204.29, 128/205-3-2, 128/205.24, 128/205.11, 128/200.22, 128/200.24, 128/203.12, 128/203.13, 128/203.28, 128/205.18, 128/910, 128/911
• US Class Current: 128/204.21
• CPC Class Codes: A61M 16/0045 Means for re-breathing exhaled gases, e.g. for hyperventilation treatment
• CPC Class Codes: A61M 16/08 Bellows; Connecting tubes having means for taking samples G01N1/22; Water traps; Patient circuits
• CPC Class Codes: A61M 16/12 by mixing different gases

Abstract

A method of controlling PCO₂ in a patient at a predetermined desired level(s) comprising a breathing circuit which is capable of organizing exhaled gas so as to be preferentially inhaled during re-breathing when necessary by providing alveolar gas for re-breathing in preference to dead space gas.

Claims

1. A method of controlling partial pressure of carbon dioxide in a patient at a predetermined desired level(s), comprising drawing back an alveolar gas exhaled by the patient into a fresh gas flow for the patient to inhale when a minute ventilation of the patient is no less than the fresh gas flow.

2. The method of claim 1, further comprising a step of preventing a gas exhaled by the patient from being supplied to the fresh gas flow when the minute ventilation is less than the fresh gas flow.

3. A breathing circuit, comprising:

a port through which a patient exhales an inhalation gas and exhales an exhalation gas;

an inspiratory limb having a first end connected to the port and a second end, the inspiratory limb supplying the inhalation gas to the patient;

an expiratory limb having a first end connected to the port and a second end, the patient exhaling the exhalation gas to the expiratory limb;

a bypass conduit connecting the inspiratory limb and the expiratory limb at the second ends thereof; and

a one-way check valve disposed in the bypass conduit in a proximity of the second end of the expiratory limb, the one-way check valve being operative to direct the exhalation gas into the inspiratory limb when a pressure differential applied thereon reaches a predetermined level.

4. The breathing circuit of claim 3, wherein the inspiratory limb further comprises a one-way check valve operative to prevent the inhalation gas flowing from the first end to the second end of the inspiratory limb.

5. The breathing circuit of claim 3, wherein the expiratory limb further comprises a one-way check valve operative to prevent the exhalation gas flowing from the second end to the first end of the expiratory limb.

6. The breathing circuit of claim 3, further comprising:

a fresh gas inlet connected to the inspiratory limb for supplying a fresh gas; and

a reservoir bag connected to the second end of the inspiratory limb for storing the fresh gas.

7. The breathing circuit of claim 3, further comprising a reservoir tube with a first end connected to the second end of the expiratory limb for retaining a predetermined part of the exhalation gas and an open second end.

8. The breathing circuit of claim 7, wherein the reservoir tube is made of a rigid tubing material or a flexible tubing material.

9. The breathing circuit of claim 7, wherein the reservoir tube includes a collapsible bag with a diameter larger than 22 mm.

10. The breathing circuit of claim 7, wherein the reservoir tube has a total volume determined according to the weight of the patient.

11. The breathing circuit of claim 7, wherein the reservoir tube has a total volume of about 3 L.

12. A method of enhancing a diagnostic procedure or medical treatment comprising the steps of:

providing a breathing circuit with an inspiratory path for supplying an inhalation gas to a patient and an expiratory path to which the patient exhaling an exhalation gas;

supplying a fresh gas as the inhalation gas for the patient to breathe;

drawing back a last exhalation gas exhaled by the patient in a previous breathing cycle as a part of the inhalation gas for the patient to rebreathe; and

increasing the flow of the last exhalation gas to be rebreathed by reducing the flow of the fresh gas when the patient is ventilating at a rate greater than the flow of the fresh gas and inducing hypercapnia to the patient is required.

13. A method of treating a patient during a traumatic event characterized by hyperventilation comprising the steps of:

providing a fresh gas to the patient, the flow of the fresh gas being equal to an alveolar ventilation of the patient;

introducing an alveolar gas exhaled by the patient into the fresh gas to prevent the alveolar ventilation from increasing due to increase of a minute ventilation of the patient; and

continuously introducing the alveolar gas into the fresh gas until the traumatic event is terminated.

14. The method of claim 13, wherein the traumatic event includes shivering and tremors during labor, post-anesthesia, and hypothermia.

15. The method of claim 13, wherein the traumatic event includes fetal distress due to asphyxia.

16. The method of claim 13, wherein the step of introducing an alveolar gas further comprises:

inducing cerebral vasodilatation, preventing cerebral vasospasm, and providing cerebral protection following subarachnoid hemorrhage, and cerebral trauma.

17. The method of claim 13, wherein the step of introducing an alveolar gas further comprises increasing tissue perfusion in tissues containing cancerous cells to increase sensitivity thereof for ionizing radiation and delivery of chemotherapeutic agents.

18. The method of claim 13, wherein the step of introducing an alveolar gas further comprises providing contrast between tissues with normal and abnormal vascular response to aid radiodiagnostic procedures.

19. A method of controlling partial pressure of carbon dioxide of a patient at a predetermined desired level, comprising the steps of:

supplying only a fresh gas from a gas input to the patient during an inspiratory phase thereof when a minute ventilation is equal to or less than a flow rate of the fresh gas supplied by the gas input;

accumulating the fresh gas in a fresh gas reservoir during an expiratory phase of the patient;

collecting an alveolar gas exhaled from the patient at an end of the expiratory phase;

providing only the fresh has supplied from the gas input to the patient during a next inspiratory phase when the minute ventilation is equal to or less than the flow rate of the fresh has supplied by the gas input;

supplying the fresh gas accumulated in the fresh gas reservoir when the minute ventilation exceeds the flow rate of the fresh gas supplied from the gas input; and

adding the alveolar gas for the patient to rebreathe.

20. The method of claim 19, wherein the step of adding the alveolar gas is performed when the fresh gas reservoir is emptied during the next inspiratory phase.