Method and apparatus for controlling blood volume and hydration and for indicating resuscitation status of a patient using peripheral venous pressure as a hemodynamic parameter

• US 6,623,470 B2
• Filed: 06/27/2001
• Issued: 09/23/2003
• Est. Priority Date: 06/27/2001
• Status: Expired due to Fees

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Lozada, Leonardo Jose, Munis, James Robert, Zura, Andrew Michael
• Primary Examiner(s): Lazarus, Ira S.
• Assistant Examiner(s): NGUYEN, CAMTU TRAN
• Application Number:
  US09/892,820
• Publication Number:
  US 20030004492A1
• Time in Patent Office: 818 Days
• Field of Search: 604/503, 604/65, 604/66, 604/67, 604/131, 604/500, 604/50, 604/246, 604/247, 604/118, 600/486, 600/485
• US Class Current: 604/503
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence

Abstract

An apparatus for controlling fluid volume in a patient includes a fluid source (16) and a fluid conduit (32, 34, 36) for carrying fluid from the fluid source to the patient (12). A controllable infusion pump (30) pumps fluid from the fluid source to a peripheral vein of the patient through the fluid conduit. An occluder (100) for blocks fluid communication between the fluid source and the patient through the fluid conduit. A fluid pressure sensor (80) periodically senses fluid pressure in the fluid conduit. The apparatus further includes a controller (86) for determining a peripheral venous pressure value from the sensed fluid pressure in the fluid conduit after the infusion pump is stopped and the occluder blocks the fluid communication between the fluid source and the patient through the fluid conduit. The peripheral venous pressure is indicative of the patient'"'"'s means systemic pressure and the fluid volume of the patient.

Claims

1. An apparatus for measuring mean systemic pressure in a patient, comprising:

a fluid source;

a fluid conduit for carrying fluid from said fluid source to the patient;

a pump for pumping fluid from said fluid source into the patient through said fluid conduit;

a pressure sensing transducer coupled with said fluid conduit for measuring fluid pressure in said fluid conduit and providing a measured fluid pressure signal indicative thereof; and

control means for controlling said pump and for controlling fluid communication through said fluid conduit so that the measured fluid pressure signal provided by said pressure sensing transducer is indicative of the mean systemic pressure of the patient.

2. The apparatus of claim 1 wherein said control means for controlling said pump controls said pump in response to the measured fluid pressure signal indicative of the mean systemic pressure of the patient so as to maintain the mean systemic pressure of the patient within a target range.

3. The apparatus of claim 2 wherein said control means includes an open loop controller.

4. The apparatus of claim 2 wherein said control means includes a closed loop controller.

5. An apparatus for measuring peripheral venous pressure in a patient, comprising:

a fluid source;

a fluid conduit for carrying fluid from said fluid source to the patient;

a pump for pumping fluid from said fluid source into the patient through said fluid conduit; and

a pressure sensing transducer coupled with said fluid conduit for measuring fluid pressure in said fluid conduit and providing a measured fluid pressure signal indicative thereof; and

control means for controlling said pump and for controlling fluid communication through said fluid conduit so that the measured fluid pressure signal provided by said pressure sensing transducer is indicative of the peripheral venous pressure of the patient.

6. The apparatus of claim 5 wherein said control means for controlling said pump controls said pump in response to the measured fluid pressure signal indicative of the peripheral venous pressure of the patient so as to maintain the peripheral venous pressure of the patient within a target range.

7. The apparatus of claim 6 wherein said control means includes an occluder for occluding said fluid conduit to isolate said fluid source from the patient when said pressure sensing transducer measures fluid pressure in said fluid conduit indicative of the peripheral venous pressure of the patient.

8. The apparatus of claim 6 wherein said control means includes an open loop controller.

9. The apparatus of claim 6 wherein said control means includes a closed loop controller.

10. The apparatus of claim 6 wherein said control means controls said pump to one of three flow rates.

11. The apparatus of claim 10 wherein said control means controls said pump flow rate in response to the measured peripheral venous pressure so as to have a low flow rate to lower the peripheral venous pressure of the patient, a maintenance flow rate to maintain the peripheral venous pressure of the patient at a present pressure, and a high flow rate to increase the peripheral venous pressure of the patient.

12. An apparatus comprising:

a fluid source;

an electrically controlled pump for pumping fluid from said fluid source through a fluid conduit into a patient;

a pressure sensing transducer for measuring a mean systemic pressure of the patient and providing a means systemic pressure signal indicative thereof; and

control means for automatically controlling said pump in response to said means systemic pressure signal indicative of the measured mean systemic pressure of the patient.

13. The apparatus of claim 12 wherein said control means for controlling said pump includes an open loop controller.

14. The apparatus of claim 12 wherein said control means for controlling said pump includes a closed loop controller.

15. The apparatus of claim 12 wherein said pressure sensing transducer measures pressure in a peripheral vein of the patient.

16. An apparatus comprising:

a fluid source;

an electrically controlled pump for pumping fluid from said fluid source through a fluid conduit to a patient;

a pressure sensing transducer for measuring peripheral venous pressure of the patient and providing a peripheral venous pressure signal indicative thereof; and

control means for automatically controlling said pump in response to said peripheral venous pressure signal indicative of the measured peripheral venous pressure of the patient.

17. The apparatus of claim 16 wherein said control means for controlling said pump includes an open loop controller.

18. The apparatus of claim 16 wherein said control means for controlling said pump includes a closed loop controller.

19. An apparatus for controlling fluid volume in a patient comprising:

a fluid source;

a fluid conduit for carrying fluid from said fluid source to the patient;

a controllable infusion pump for pumping fluid from said fluid source to a peripheral vein of the patient through said fluid conduit;

controllable occluder for, when actuated, blocking fluid communication between said fluid source and the patient through said fluid conduit;

fluid pressure sensor for sensing fluid pressure in said fluid conduit; and

controller for controlling operation of said infusion pump and said occluder and for determining a peripheral venous pressure value from said sensed fluid pressure in said fluid conduit after said infusion pump is stopped by said controller and said controller actuates said occluder to block said fluid communication between said fluid source and the patient through said fluid conduit, said peripheral venous pressure being indicative of fluid volume of the patient.

20. The apparatus of claim 19 wherein said fluid conduit includes a disposable cassette having a pumping chamber and a pressure sensing chamber, said cassette being mountable within said infusion pump, said pressure sensor operatively coupled to said pressure sensing chamber and said occluder being located between said fluid source and said pressure sensing chamber.

21. The apparatus of claim 19 wherein said controller includes timing means for timing out a predetermined time period after said infusion pump is stopped, said controller determining said peripheral venous pressure based on sensed fluid pressure in said fluid conduit after said time period.

22. The apparatus of claim 19 wherein said controller includes means for determining said peripheral venous pressure value in response to averaging a plurality of said sensed pressure measurements in said fluid conduit and means for displaying said peripheral venous pressure.

23. An apparatus for controlling fluid volume in a patient comprising:

a fluid source;

a controllable infusion pump connected to said fluid source through a fluid inlet line;

a catheter inserted in a peripheral vein of a patient and connected to an outlet of said infusion pump through a fluid outlet line so as to provide a fluid communication path between the peripheral vein of the patient and said pump, activation of said pump resulting in fluid being delivered to the patient from said fluid source through said catheter;

an in-line pressure sensing transducer positioned substantially at a heart level of the patient for sensing pressure in the fluid communication path and providing a pressure measurement signal indicative thereof;

an actuatable in-line occluder for isolating said fluid source from the patient when the occluder is actuated;

control means for periodically stopping said infusion pump, actuating said occluder, monitoring said pressure measurement signal, and determining a peripheral venous pressure value of the patient in response thereto; and

means for adjusting operation of said infusion pump in response to the determined peripheral venous pressure value.

24. The apparatus of claim 23 further including a disposable cassette having a pumping chamber and a pressure sensing chamber, said cassette being mountable within said infusion pump, said pressure sensing transducer being operatively coupled to said pressure sensing chamber and said occluder being located between said fluid source and said pressure sensing chamber.

25. The apparatus of claim 23 wherein said control means includes timing means for timing out a predetermined time period after said pump is stopped, said peripheral venous pressure being determined after said time period.

26. The apparatus of claim 23 wherein said control means determines said peripheral venous pressure in response to an averaging of a plurality of said pressure measurement signal, said apparatus further including means for displaying said peripheral venous pressure.

27. A method for measuring mean systemic pressure in a patient, comprising the steps of:

connecting a fluid source to the patient through a fluid conduit;

pumping fluid from the fluid source into the patient through the fluid conduit; and

measuring fluid pressure using a pressure sensing transducer coupled to the fluid conduit by controlling the pumping and the flow of fluid from the fluid source to the patient so that the measured pressure with the pressure sensing transducer is indicative of the mean systemic pressure of the patient.

28. The method of claim 27 further including the step of controlling said pumping of fluid in response to the measured fluid pressure to maintain the mean systemic pressure of the patient within a target range.

29. The method of claim 28 wherein the step of controlling is open loop.

30. The method of claim 28 wherein the step of controlling is closed loop.

31. A method for measuring peripheral venous pressure in a patient, comprising the steps of:

connecting a fluid source to the patient through a fluid conduit;

pumping fluid from the fluid source into the patient through the fluid conduit; and

measuring fluid pressure using a pressure sensing transducer coupled to the fluid conduit by controlling the pumping and the flow of fluid from the fluid source to the patient so that the measured fluid pressure with the pressure sensing transducer is indicative of the peripheral venous pressure of the patient.

32. The method of claim 31 wherein the step of controlling fluid flow further includes the step of occluding the fluid conduit to prevent fluid flow from the fluid source to the patient before the step of measuring fluid pressure with the pressure sensing transducer indicative of the peripheral venous pressure of the patient.

33. The method of claim 31 wherein the step of controlling pumping further includes the step of controlling pumping of fluid in response to the peripheral venous pressure of the patient so as to maintain the peripheral venous pressure of the patient within a target range.

34. The method of claim 33 wherein said step of controlling pumping is open loop.

35. The method of claim 33 wherein said step of controlling pumping is closed loop.

36. The method of claim 33 wherein said step of controlling pumping includes controlling pumping to provide one of three possible flow rates.

37. The method of claim 31 wherein the step of controlling pumping further includes the step of controlling the pumping of fluid so as to pump at a low flow rate when the peripheral venous pressure of the patient needs lowered, at a maintenance flow rate when the peripheral venous pressure of the patient is to be maintained at a present pressure, and at a high flow rate when the peripheral venous pressure of the patient needs to be increased.

38. A method for controlling fluid volume in a patient comprising the steps of:

connecting a fluid source to the patient through a fluid conduit;

periodically pumping fluid with an infusion pump from the fluid source to a vein of the patient through the fluid conduit;

periodically occluding fluid communication between the fluid source and the patient through the fluid conduit;

periodically sensing fluid pressure in the fluid conduit with a pressure sensing transducer;

monitoring the sensed fluid pressure in the fluid conduit after the step of pumping stops, and the step of occluding blocks the fluid communication between the fluid source and the patient through the fluid conduit;

providing an electronic signal indicative of the monitored fluid pressure, the monitored fluid pressure being indicative of fluid volume of the patient; and

controlling said pumping step in response to the electronic signal indicative of the monitored fluid pressure so as to control the fluid volume in the patient.

39. The method of claim 38 further including the step of timing out a predetermined time period after stopping of said pump, said step of monitoring the sensed fluid pressure in said fluid conduit occurring after said time period.

40. The apparatus of claim 38 wherein said step of monitoring includes determining an average of said pressure measurement signals and said method further includes the step of displaying said electronic signal indicative of the fluid volume.

41. A method comprising the steps of:

pumping fluid from a fluid source into a patient;

measuring a value functionally related to mean systemic pressure of the patient; and

controlling said pumping in response to said measured value functionally related to mean systemic pressure of the patient.

42. A method comprising the steps of:

pumping fluid from a fluid source to a patient;

measuring peripheral venous pressure of the patient; and

controlling said pumping in response to said measured peripheral venous pressure of the patient.