Administration of lycopene for combating skin/mucous membrane damage

• US 6,623,769 B1
• Filed: 10/10/2000
• Issued: 09/23/2003
• Est. Priority Date: 10/07/1999
• Status: Expired due to Term

• Current Assignee: Societe L'Oreal S.A.
• Original Assignee: Societe L'Oreal S.A.
• Inventors: Breton, Lionel, Lorant, Raluca, Liviero, Christel
• Primary Examiner(s): Witz, Jean C.
• Application Number:
  US09/684,984
• Time in Patent Office: 1,078 Days
• Field of Search: 424/777, 424/725, 514/456, 514/458, 514/725, 514/764, 514/886
• US Class Current: 424/777
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 19/04 for chemically tanning the skin topical sun or radiation screening or tanning preparations A61Q17/04
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Lycopene and compositions comprised thereof, for example tomato plant extracts, are uniquely suited for treating, preventively and/or curatively, cutaneous signs of aging, in particular inhibiting damage to the skin and/or mucous membranes via inhibition of collagenases.

Claims

1. A method for treating an individual having cutaneous signs of aging caused by expression of proteases in the extracellular matrix comprising administering to said individual an amount of lycopene effective to substantially inhibit the expression of said proteases in the extracellular matrix of said individual.

2. The method as defined by claim 1, said lycopene being natural in origin.

3. The method as defined by claim 1, said lycopene being synthetic in origin.

4. The method as defined by claim 1, comprising administering pure lycopene or solution thereof.

5. The method as defined by claim 1, comprising administering a lycopene-containing plant extract.

6. The method as defined by claim 5, comprising administering a lycopene-containing tomato plant extract.

7. The method as defined by claim 6, comprising administering an oleoresin tomato plant extract containing 6% of lycopene.

8. The method as defined by claim 1, comprising administering a composition containing from 10⁻

12% to 20% by weight of lycopene.

9. The method as defined by claim 8, comprising administering a composition containing from 10⁻

8% to 10% by weight of lycopene.

10. The method as defined by claim 8, said composition being formulated for topical application onto the skin, hair and/or mucous membranes.

11. The method as defined by claim 8, said composition being formulated for oral ingestion.

12. The method as defined by claim 11, said composition comprising a syrup, tablet, capsule, or nutritional food or supplement.