Method for treatment diseases associated with a deterioration of the macrocirculation, microcirculation and organ perfusion

• US 6,627,151 B1
• Filed: 06/10/1998
• Issued: 09/30/2003
• Est. Priority Date: 06/13/1997
• Status: Expired due to Fees

• Current Assignee: Helmut Borberg, Michael Tauchert, Richard Brunner
• Original Assignee: Helmut Borberg, Michael Tauchert, Richard Brunner
• Inventors: Brunner, Richard, Tauchert, Michael, Borberg, Helmut
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US09/095,472
• Time in Patent Office: 1,938 Days
• Field of Search: 422/44, 604/4, 604/4.01, 604/5-1-, 604/6.01, 604/6.04, 604/6.09, 210/650-52, 210/660, 210/663, 210/669, 210/679, 128/898, 514/802, 424/130.1, 424/140.1, 435/2, 435/283.1
• US Class Current: 422/44
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3482 by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence

Abstract

The invention relates to a method for the effective treatment of diseases associated with a deterioration of the macrocirculation, microcirculation and organ perfusion to achieve an improvement of the local environment and the metabolic situation and to aim at the improvement of organ function or the stabilization of organ function with imminent functional deterioration, which comprises the treatment of blood of patients by extracorporeal plasmapheresis techniques.

Claims

1. A method of treating small vessel disease of a heart in a subject diagnosed with small vessel disease of the heart, comprising the steps of withdrawing blood from the subject, treating the blood by plasmapheresis, and reinfusing the treated blood into the subject, thereby treating the small vessel disease of the heart.

2. A method of treating small vessel disease of a heart in a subject diagnosed with small vessel disease of the heart, comprising the steps of withdrawing blood from the subject, treating the blood by removing high molecular weight protein, and reinfusing the treated blood into the subject, thereby treating the small vessel disease of the heart.

3. The method of claim 2, wherein the high molecular weight protein is selected from the group consisting of fibrinogen, low density lipoprotein cholesterol, alpha-2-macroglobulin and a mixture thereof.