Composition set and kit for use in intraocular surgery

• US 6,627,620 B1
• Filed: 06/29/2001
• Issued: 09/30/2003
• Est. Priority Date: 12/18/1998
• Status: Expired due to Term

• Current Assignee: Per Julius Nielsen
• Original Assignee: Per Julius Nielsen
• Inventors: Nielsen, Per Julius
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US09/868,136
• Time in Patent Office: 823 Days
• Field of Search: 514/54, 514/912, 424/78.04
• US Class Current: 514/54
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: A61P 23/02 Local anaesthetics
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

A new composition set and a kit for use by intraocular operations, preferably cataract operations. The composition set comprises a first and a second viscoelastic agent, e.g. sodium hyaluronate, containing an anaesthetic, e.g. lidocaine hydrochloride. Hereby a simplified operation and anaesthesia is achieved while at the same time the risk of complications and discomfort on the patient are reduced.

Claims

1. A composition set for use in intraocular surgery comprising a first viscoelastic agent which contains a first concentration of at least one first anaesthetic suitable for use in internal viscoanaesthesia and a second viscoelastic agent which contains a second concentration of at least one second anaesthetic suitable for use in external viscoanaesthesia.

2. A composition set according to claim 1, wherein said first and second anaesthetic comprise a local anaesthetic.

3. A composition set according to claim 1, wherein said first and second anaesthetics comprise lidocaine hydrochloride and said first and second viscoelastic agents comprise sodium hyaluronate.

4. A composition set according to claim 1, wherein said first and second anaesthetics comprise lidocaine hydrochloride at a concentration between 0.5 and 5%, and wherein said first and second viscoelastic agent is sodium hyaluronate in concentrations between 5 and 40 mg/ml in Ringer lactate solution.

5. A composition set according to claim 1, wherein said first viscoelastic agent is sodium hyaluronate comprising as anaesthetic agent lidocaine hydrochloride in a concentration between 0.5 and 5%, and wherein said second viscoelastic agent is sodium hyaluronate comprising as anaesthetic agent lidocaine hydrochloride in a concentration between 2 and 6%.

6. A composition set according to claim 1, wherein said first and second agents are pH-adjusted and balanced with respect to osmosis and salt with the purpose of avoiding discomfort when applied to a patient.

10. A composition set according to claim 4, wherein said first and second anaesthetics comprise lidocaine hydrochloride in a concentration of 1% and sodium hyaluronate in a concentration between 10 and 20 mg/ml.

11. A composition set according to claim 5, wherein said first viscoelastic agent comprises lidocaine hydrochloride in a concentration of 1% and said second viscoelastic agent comprises lidocaine hydrochloride in a concentration of 4%.

7. A kit for use in intraocular surgery comprising a first viscoelastic agent and second viscoelastic agent, comprising

a sterile packaged first hypodermic syringe containing the first viscoelastic agent including at least a first anaesthetic and a hypodermic needle ready for injection, and

a second hypodermic syringe containing said second viscoelastic agent as well with a second anaesthetic mixed therein and which is used for external viscoanaesthesia.

8. A kit according to claim 7, wherein said first syringe comprises sodium hyaluronate with lidocaine hydrochloride in a concentration between 0.5 and 5%, and wherein the second syringe comprises sodium hyaluronate with lidocaine hydrochloride in a concentration between 2 and 6%.

9. A kit according to claim 7, wherein both the first and the second syringe contain sodium hyaluronate or mixtures of other viscoelastics in concentrations between 5 and 40 mg/ml.

12. A kit according to claim 8, wherein said first syringe comprises lidocaine hydrochloride in a concentration of 1% and said second syringe comprises lidocaine hydrochloride in a concentration of 4%.

13. A kit according to claim 9, wherein said concentrations are between 10 and 20 mg/ml.