Bubble measuring instrument and method

• US 6,629,449 B1
• Filed: 03/26/2002
• Issued: 10/07/2003
• Est. Priority Date: 02/04/2000
• Status: Expired due to Fees

• Current Assignee: United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration
• Original Assignee: United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration
• Inventors: Magari, Patrick J., Kline-Schoder, Robert
• Primary Examiner(s): Williams, Hezron
• Assistant Examiner(s): Wiggins, David J.
• Application Number:
  US10/113,645
• Time in Patent Office: 560 Days
• Field of Search: 73/190.3, 73/617.5, 73/617.1, 73/530.1, 73/190.1, 73/191, 382/141, 382/133, 356/243.2, 356/239.6, 356/335
• US Class Current: 73/19.03
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/4209 by using holders, e.g. positioning frames
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: G01N 2291/014 Resonance or resonant frequency
• CPC Class Codes: G01N 2291/02433 Gases in liquids, e.g. bubbles, foams
• CPC Class Codes: G01N 2291/0421 Longitudinal waves
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves
• CPC Class Codes: G01N 29/348 with frequency characteristics, e.g. single frequency signals, chirp signals measuring frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04; measuring frequency or analysing frequency spectra G01R23/00
• CPC Class Codes: G01N 29/42 by frequency filtering or by tuning to resonant frequency
• CPC Class Codes: G01N 29/46 by spectral analysis, e.g. Fourier analysis or wavelet analysis spectral signal processing per se G06F17/14
• CPC Class Codes: G01S 7/52026 Extracting wanted echo signals Doppler systems G01S15/50; Doppler short range imaging systems G01S15/8979
• CPC Class Codes: G01S 7/52036 using analysis of echo signal for target characterisation
• CPC Class Codes: Y10S 128/916 Ultrasound 3-D imaging

Abstract

Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer, respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

Claims

1. A video bubble sizing test system for performing dynamic bubble measurements, comprising:

a video camera with software and associated memory for capturing a set of video images of a group of bubbles as said group of bubbles moves along a fluid flowpath over a time interval, which video camera includes software and memory means for measuring bubble sizes in comparison to a known reference size or scale, a sight tube extending along said fluid flowpath and containing said group of moving bubbles, and

a strobe for producing a plurality of separate video frames that show said bubbles resolved and separated over said time interval so as to facilitate said video bubble sizing.

2. The video bubble sizing test system of claim 1, further comprising:

a video monitor for viewing said separate video frames with bubbles therein.

3. The video bubble sizing test system of claim 1, further comprising:

said software being operable for providing statistically independent frames such that the same bubble is not measured twice in said separate video frames.

4. The video bubble sizing test system of claim 1, further comprising:

a bubble generator operable for selectively generating bubbles having varying diameters.

5. The video bubble sizing test system of claim 4, wherein said bubble generator is operable for generating bubbles at least over the range of 40 micrometers to 200 micrometers.

6. The video bubble sizing test system of claim 1, further comprising:

a tissue phantom through which said bubbles flow.

7. The video bubble sizing test system of claim 6, further comprising:

said ultransonic bubble monitor being positioned adjacent said tissue phantom for monitoring bubbles in said tissue phantom.

8. The video bubble sizing test system of claim 1, further comprising:

a peristaltic pump for pumping fluid so as to mimic blood flow.

9. A bubble diameter measuring apparatus for performing dynamic bubble measurements, comprising:

a controller device which is electrically connected to a bubble measuring detector, where said controller device is configured and operated to generate a set of control software that varies in response to an output from said bubble measuring detector, and a software-controlled computer with an associated memory that is operable for producing a virtual instrument on a computer monitor; and

a selection indicator on said virtual instrument for selecting a range of bubble diameters to be examined by said bubble measuring detector and software-controlled computer.

10. The bubble measuring apparatus of claim 9, further comprising:

a screen for said virtual instrument for displaying a frequency domain signal related to a particular size bubble.

11. The bubble measuring apparatus of claim 9, further comprising:

one or more selection indicators for selecting an amplitude and frequency range of said time domain signal to thereby determine whether a bubble is detected or not.

12. The bubble measuring apparatus of claim 10, further comprising:

a second screen for said virtual instrument with the capability of forming a virtual image for displaying a Doppler signal.

13. The bubble measuring apparatus of claim 9, further comprising:

a selection indicator on said virtual instrument for selecting a frequency increment related to said range of bubble diameters to be examined.

14. A bubble measuring apparatus, comprising:

a software controlled computer operable for producing a virtual instrument on a computer monitor;

a selection indicator on said virtual instrument for selecting a range of bubble diameters to be examined;

a screen for said virtual instrument for displaying a frequency domain signal related to a particular bubble size; and

software for generating summary charts that display the number of bubbles detected over a selected range of bubble diameters.