Drug delivery pump with isolated hydraulic metering

• US 6,629,954 B1
• Filed: 01/31/2000
• Issued: 10/07/2003
• Est. Priority Date: 01/31/2000
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Heruth, Kenneth T.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Sirmons, Kevin C.
• Application Number:
  US09/495,211
• Time in Patent Office: 1,345 Days
• Field of Search: 604/131-133, 604/140, 604/141, 604/145, 604/146, 604/890.1, 604/891.1, 604/892.1, 604/93.01
• US Class Current: 604/131
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence

Abstract

A medical device and more particularly a drug delivery pump has an hydraulic reservoir, a metering device, a displacement reservoir, a drug reservoir, and a drug infusion port all contained in a housing that can either be attached to or implanted into a patient. The hydraulic reservoir contains an hydraulic fluid that is under compression and flows through the metering device at an hydraulic rate. The hydraulic metering is isolated from the drug, and the metering device does not contain moving parts. The hydraulic fluid then flows into the displacement reservoir that applies pressure to the drug reservoir. The drug reservoir is compressible and adapted to contain a drug. As the drug reservoir is compressed, drug egresses through the drug infusion port at an infusion rate that is controlled by hydraulic rate. A method for filling the drug pump and a method for infusing drug from the drug pump are also disclosed.

Claims

1. A drug delivery pump with isolated hydraulic metering comprising:

a housing compatible with a human body;

a drug reservoir disposed in the housing, the drug reservoir having a drug reservoir interior and the drug reservoir being compressible and adapted to contain a drug;

a drug infusion port coupled to the drug reservoir extending through the housing, the drug infusion port providing for drug egress from the drug reservoir interior though the housing,

an hydraulic reservoir disposed in the housing, the hydraulic reservoir having an hydraulic reservoir interior, and the hydraulic reservoir being adapted to contain hydraulic fluid;

a metering device without moving parts, wherein the metering device is a capillary tube in fluid contact with the hydraulic reservoir interior, the capillary tube controlling the rate that the hydraulic fluid flows from the hydraulic reservoir; and

a displacement reservoir in fluid contact with the capillary tube, the displacement reservoir receiving the hydraulic fluid flowing though the capillary tube and the displacement reservoir applying pressure to compress the drug reservoir which dispenses the drug at a predetermined infusion rate through the drug infusion port;

wherein the capillary tube has an inside diameter in the range from about 0.000254 cm to about 0.0254 cm.

2. A drug delivery pump with isolated hydraulic metering, comprising:

a housing compatible with a human body;

a drug reservoir disposed in the housing, the drug reservoir having a drug reservoir interior and the drug reservoir being compressible and adapted to contain a drug;

a drug infusion port coupled to the drug reservoir extending through the housing, the drug infusion port providing for drug egress from the drug reservoir interior though the housing;

an hydraulic reservoir disposed in the housings the hydraulic reservoir having an hydraulic reservoir interior, and the hydraulic reservoir being adapted to contain hydraulic fluid;

a metering device without moving parts, wherein the metering device is a capillary tube in fluid contact with the hydraulic reservoir interior, the capillary tube controlling the rate that the hydraulic fluid flows from the hydraulic reservoir; and

a displacement reservoir in fluid contact with the capillary tube, the displacement reservoir receiving the hydraulic fluid flowing though the capillary tube and the displacement reservoir applying pressure to compress the drug reservoir which dispenses the drug at a predetermined infusion rate through the drug infusion port;

wherein the capillary tube has a length in the range from about 0.05 cm to about 5.0 cm.

3. A drug delivery pump with isolated hydraulic metering, comprising:

a housing compatible with a human body;

a drug reservoir disposed in the housing, the drug reservoir having a drug reservoir interior and the drug reservoir being compressible and adapted to contain a drug;

a drug infusion port coupled to the drug reservoir extending through the housing, the drug infusion port providing for drug egress from the drug reservoir interior though the housing;

an hydraulic reservoir disposed in the housing, the hydraulic reservoir having an hydraulic reservoir interior, and the hydraulic reservoir being adapted to contain hydraulic fluid;

a metering device without moving parts in fluid contact with the hydraulic reservoir interior, the metering device controlling the rate that the hydraulic fluid flows from the hydraulic reservoir; and

a displacement reservoir in fluid contact with the metering device, the displacement reservoir receiving the hydraulic fluid flowing though the metering device and the displacement reservoir applying pressure to compress the drug reservoir which dispenses the drug at a predetermined infusion rate through the drug infusion port;

wherein the displacement reservoir is residential space in the housing surrounding the drug reservoir.

4. An drug delivery pump with isolated hydraulic metering, comprising:

a housing compatible a human body;

a drug reservoir disposed in the housing, the drug reservoir having a drug reservoir interior and the drug reservoir being compressible and adapted to contain a drug;

a drug infusion port coupled to the drug reservoir extending through the housing, the drug infusion port providing for drug egress from the drug reservoir interior through the housing;

means for hydraulic fluid containment disposed in the housing, the means for hydraulic fluid containment having an hydraulic containment interior,

and the means for hydraulic fluid containment being adapted to contain an hydraulic fluid;

means for metering without moving parts in fluid contact with the hydraulic containment interior, the means for metering controlling the rate that the hydraulic fluid flows from the means for hydraulic containment; and

,

means for displacement containment in fluid contact with the means for metering, the means for displacement containment receiving the hydraulic fluid flowing through the means for metering and the means for displacement containment applying pressure to the drug reservoir which infuses the drug at a predetermined infusion rate through the drug infusion port.

5. The drug delivery pump as in claim 4 wherein the predetermined dispense rate is a function of both the means for metering and the hydraulic fluid'"'"'s flow characteristics.

6. The drug delivery pump as in claim 4 wherein the predetermined dispense rate is changed by varying only the hydraulic fluid'"'"'s flow characteristics.

7. The drug delivery pump as in claim 4 wherein the means for metering provides a continuous flow path.

8. An isolated hydraulic metering system for a drug delivery pump, comprising:

means for hydraulic containment for receiving an hydraulic fluid;

means for metering without moving parts fluidly coupled to the means for hydraulic containment for dispensing the hydraulic fluid from the means for hydraulic containment at a predetermined hydraulic rate; and

,

means for displacement containment fluidly coupled to the means for metering for receiving the hydraulic fluid flowing through the means for metering at the predetermined hydraulic rate for compressing a drug reservoir to dispense a drug at a predetermined dispense rate.

9. The drug delivery pump as in claim 8 wherein the predetermined hydraulic rate is a function of both the means for metering and the hydraulic fluid'"'"'s flow characteristics.

10. The drug delivery pump as in claim 8 wherein the predetermined dispense rate is changed by varying only the hydraulic fluid'"'"'s flow characteristics.

11. The drug delivery pump as in claim 8 wherein the means for metering provides a continuous flow path.

12. A method for filling a drug delivery pump with hydraulic metering comprising:

inserting a filling device containing drug through a drug fill port;

filling a drug reservoir with a drug dispensed from the filling device through the drug fill port into the drug reservoir;

compressing hydraulic fluid contained in a displacement reservoir with the drug reservoir as the drug reservoir expands when being filled;

opening a relief valve when the pressure of the compressed hydraulic fluid exceeds the relief pressure of the relief valve;

filling an hydraulic reservoir with hydraulic fluid flowing from the displacement reservoir through the relief valve into the hydraulic reservoir;

closing the relief valve when the pressure of the hydraulic fluid outside the hydraulic reservoir is less than the relief pressure.

13. The method of filling a drug delivery pump as in claim 12, further comprising closing a infusion valve to stop drug flow from the drug reservoir through an infusion port while filling the drug reservoir.

14. The method of filling a drug delivery pump as in claim 12, comprising compressing propellant contained in a hydraulic reservoir space when the hydraulic reservoir hydraulic fluid.

15. A drug delivery pump with isolated hydraulic metering, comprising:

a housing compatible with a human body;

a compressible drug reservoir disposed within the housing, the drug reservoir adapted to contain a drug;

a drug infusion port in fluid contact with the drug reservoir and extending through the housing such that the drug can egress the drug reservoir when the drug reservoir is compressed;

a compressible hydraulic reservoir disposed within the housing, the hydraulic reservoir adapted to contain and to dispense a hydraulic fluid when the hydraulic reservoir is compressed;

a metering device without moving parts in fluid contact with hydraulic reservoir to control the rate that the hydraulic fluid flows from the hydraulic reservoir;

a displacement reservoir in fluid contact with the metering device, the displacement reservoir receiving hydraulic fluid dispensed from the hydraulic reservoir through the metering device such that filling the displacement reservoir compresses the drug reservoir; and

a propellant reservoir coupled to the hydraulic reservoir and adapted to contain a fluid propellant, wherein expansion of the fluid propellant compresses the hydraulic reservoir.

16. The drug delivery pump as in claim 15 wherein at least one of the drug reservoir and the hydraulic reservoir includes one of the group consisting of a bellows, a diaphragm a bladder, and a cylinder.

17. The drug delivery pump of claim 15 wherein the drug includes a viscosity in the range of 0.1 to 10.0 centipoise at body temperature and the hydraulic fluid has a viscosity in the range of 100.0 to 1000.0 centipoise at body temperature.

18. The drug delivery pump as in claim 15 wherein the metering device includes a capillary tube.

19. The drug delivery pump as in claim 15 wherein the displacement reservoir is disposed within the housing such that hydraulic fluid is in direct contact with the drug reservoir but isolated from the drug.

20. The drug delivery pump as in claim 15 wherein the propellant reservoir is disposed within the housing such that the fluid propellant is in direct contact with the hydraulic reservoir but the fluid propellant is isolated from the hydraulic fluid.