Manufacture of bone graft substitutes
First Claim
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1. A method of manufacturing a three-dimensional intricately shaped bone graft substitute comprising the step of dry powder compacting a bone material into said three-dimensional intricate shape.
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Abstract
The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a granulated bone material, such as demineralized bone matrix. In addition, a processing aid is utilized to facilitate compaction of the granulated bone material and for release of the product from the die.
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Citations
33 Claims
- 1. A method of manufacturing a three-dimensional intricately shaped bone graft substitute comprising the step of dry powder compacting a bone material into said three-dimensional intricate shape.
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22. A method of manufacturing a three-dimensional intricately shaped bone graft substitute comprising the steps of:
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obtaining a bone material;
granulating said material; and
subjecting said bone material to a dry powder compaction process; and
wherein a three-dimensional intricate shape is formed by said dry powder compaction process. - View Dependent Claims (23)
a stationary lower punch;
a moveable die;
a moveable upper punch; and
a moveable lower punch, wherein said stationary lower punch is contained within said moveable lower punch and wherein said moveable lower punch is contained within the moveable die.
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24. A method of manufacturing an intricately shaped bone graft substitute from bone material, said method comprising the steps of:
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providing a stationary lower punch and a moveable lower punch which is vertically moveable about the stationary lower punch, a moveable die having at least one cavity that is vertically moveable about the moveable lower punch and positionable generally above the stationary lower punch, and a moveable upper punch that is vertically moveable inside the moveable die;
positioning the moveable die generally above the stationary lower punch;
positioning the moveable upper punch generally above the moveable die;
introducing the granulated bone material into the cavity of the moveable die;
moving the moveable upper punch to contact the bone material in opposition to the moveable lower punch and stationary lower punch; and
moving the moveable upper punch further into the cavity of the moveable die, moving the moveable die, and moving the moveable lower punch all at the same time but with different relative amplitudes, whereby said moving steps form the material into the intricately shaped bone graft substitute. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
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Specification