Hyaluronic acid anti-adhesion barrier
First Claim
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1. A method of forming an anti-adhesion barrier comprising:
- freeze-drying a solution including hyaluronic acid to form a foam;
reacting the foam with a crosslinking agent to form a crosslinked foam; and
mixing the crosslinked foam with an aqueous solution containing hyaluronic acid to form an anti-adhesion barrier.
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Abstract
Methods of forming crosslinked hyaluronic acid anti-adhesion barriers, crosslinked hyaluronic acid anti-adhesions barriers, methods for preventing or inhibiting adhesions, and methods of promoting healing of a wound are provided. The method of forming the crosslinked hyaluronic acid anti-adhesion barrier includes freeze-drying a solution including hyaluronic acid to form a hyaluronic acid foam, which is then reacted with a crosslinking agent to form a crosslinked hyaluronic acid foam. The crosslinked hyaluronic acid foam is mixed with a solution containing hyaluronic acid to form an anti-adhesion barrier.
79 Citations
37 Claims
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1. A method of forming an anti-adhesion barrier comprising:
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freeze-drying a solution including hyaluronic acid to form a foam;
reacting the foam with a crosslinking agent to form a crosslinked foam; and
mixing the crosslinked foam with an aqueous solution containing hyaluronic acid to form an anti-adhesion barrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 17, 18, 19, 20, 21, 22)
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- 12. An anti-adhesion barrier which is a gel produced by combining a freeze-dried crosslinked hyaluronic acid foam with an aqueous solution comprising hyaluronic acid.
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26. A two-part kit comprising
a first part including a freeze-dried crosslinked hyaluronic acid foam; - and a second part including a solution including hyaluronic acid.
- View Dependent Claims (27, 28, 29, 30)
- 31. An anti-adhesion barrier comprising a hyaluronic acid foam, a crosslinking agent and an aqueous solution containing hyaluronic acid.
Specification