System and method for diagnosing and/or reducing tinnitus

• US 6,631,295 B2
• Filed: 09/25/2001
• Issued: 10/07/2003
• Est. Priority Date: 02/13/1998
• Status: Expired due to Fees

• Current Assignee: Iowa University of Research Foundation
• Original Assignee: University of Iowa Research Foundation
• Inventors: Tyler, Richard S., Brown, Carolyn J., Rubinstein, Jay T.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/961,690
• Publication Number:
  US 20020091423A1
• Time in Patent Office: 742 Days
• Field of Search: 607/55-57, 623/10, 600/25
• US Class Current: 607/55
• CPC Class Codes: A61B 5/12 Audiometering
• CPC Class Codes: H04R 25/502 using analog signal processing
• CPC Class Codes: H04R 25/606 acting directly on the eardrum, the ossicles or the skull, e.g. mastoid, tooth, maxillary or mandibular bone, or mechanically stimulating the cochlea, e.g. at the oval window
• CPC Class Codes: H04R 25/75 Electric tinnitus maskers providing an auditory perception

Abstract

A system and method for application of pseudospontaneous neural stimulation is provided that can generate stochastic independent activity across an excited nerve or neural population without an additional disadvantageous sensations. High rate pulse trains, for example, can produce random spike patterns in auditory nerve fibers that are statistically similar to those produced by spontaneous activity in the normal ear. This activity is called “pseudospontaneous activity”. Varying rates of pseudospontaneous activity can be created by varying the intensity of a fixed amplitude, high rate pulse train stimulus, e.g., 5000 pps. A method and apparatus for diagnosing treatment for tinnitus with neural prosthetic devices according to the present invention that can use, for example, physiological responses to pseudospontaneous activity in an auditory nerve prior to the implementation of the neural prosthetic. Monitored patient response to the generated pseudospontaneous activity in the auditory nerve, even if temporary, can produce successful reduction or elimination in perceived tinnitus by subsequent treatment.

Claims

1. A method of diagnosing whether a human is a candidate for tinnitus reduction using a neural prosthetic, comprising:

applying a pseudospontaneous driving electrical signal capable of generating pseudospontaneous activity in an auditory nerve to an auditory nerve of a plurality of candidates;

identifying a prescribed threshold; and

selecting the candidate having an auditory response to said pseudospontaneous driving electrical signal and tinnitus perception below the prescribed threshold upon application of said pseudospontaneous driving electrical signal.

2. The method of claim 1, wherein the prescribed threshold is a percentage decrease of the tinnitus perception of the candidate.

3. The method of claim 1, wherein the prescribed threshold is substantially physiologically imperceptable to the candidate.

4. The method of claim 3, further comprising modifying the pseudospontaneous driving electrical signal to a sustained effective level while the pseudospontaneous driving electrical signal remains substantially physiologically imperceptible to the patient.

5. The method of claim 4, wherein the auditory response remains below the prescribed threshold for a prescribed time after removal of the pseudospontaneous driving electrical signal.

6. The method of claim 1, wherein the pseudospontaneous driving electrical signal includes one of (i) a pulse train generating substantially continuous activation, (ii) a broad band noise, or (iii) at least fluctuations in amplitude greater than prescribed amount at a frequency above approximately 2 k Hz.

7. The method of claim 1, wherein the applying step is performed by one of a middle ear implant and an inner ear implant, and comprises applying current to the auditory nerve, wherein the pseudospontaneous activity is demonstrated by statistically independent activity in a plurality of nerve fibers in the auditory nerve, and wherein the prescribed level is a 50% reduction of the tinnitus perception.

8. The method of claim 1, wherein the auditory nerve comprises a plurality of nerve fibers, and wherein the pseudospontaneous driving electrical signal comprises one or more signals that generate a substantially maximum firing rate of the plurality of nerve fibers.

9. A method of testing whether a patient'"'"'s tinnitus can be at least partially reduced, comprising:

applying an electrical signal capable of generating pseudospontaneous activity in an auditory nerve of at least one human to the patient'"'"'s auditory nerve;

determining the patient'"'"'s response to said electrical signal; and

adjusting, if the patient'"'"'s tinnitus is not at least partially reduced, a level of said electrical signal and repeating said determining step.

10. The method of claim 9, wherein the patient'"'"'s tinnitus is below a prescribed threshold after said adjusting step.

11. The method of claim 9, wherein the electrical signal includes one of (i) a pulse train generating substantially continuous activation, (ii) a broad band noise, or (iii) at least fluctuations in amplitude greater than prescribed amount at a frequency above approximately 2k Hz.

12. An apparatus of diagnosing whether a human is a candidate for tinnitus reduction using a neural prosthetic, comprising:

applying means for applying an electrical signal capable of generating pseudospontaneous activity in an auditory nerve of at least one human to a plurality of candidates;

identifying means for identifying a prescribed threshold; and

selecting means for selecting the candidate having an auditory response to said electrical signal and tinnitus perception below the prescribed threshold upon application of said electrical signal.

13. A method of determining residual effects to a patient with tinnitus resulting from application of a signal capable of inducing pseudo-spontaneous activity, comprising:

applying an electrical signal capable of generating pseudo-spontaneous activity in an auditory nerve of at least one human to the patient'"'"'s auditory nerve for a first time period; and

determining whether there remains a perceptible difference in the patient'"'"'s tinnitus after said first time period.

14. The method of claim 13, wherein said determining comprises determining a second time period during which said perceptible difference remains.

15. The method of claim 13, wherein said determining comprises determining whether there remains a reduction in the patient'"'"'s tinnitus.

16. The method of claim 13, wherein said determining comprises whether there remains a substantial elimination of the patient'"'"'s tinnitus.

17. The method of claim 13, further comprising repeating said applying step and said determining step using a second time period.

18. The method of claims 13, wherein the electrical signal includes one of (i) a pulse train generating substantially continuous activation, (ii) a broad band noise, or (iii) at least fluctuations in amplitude greater than prescribed amount at a frequency above approximately 2 k Hz.