Apparatus and method for selective reduction of segmental intracellular and extracellular edema

• US 6,632,192 B2
• Filed: 03/05/2001
• Issued: 10/14/2003
• Est. Priority Date: 03/05/2001
• Status: Expired due to Fees

• Current Assignee: Transvivo, Inc.
• Original Assignee: Transvivo, Inc.
• Inventors: Venkat, Kris, Gorsuch, Reynolds G.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Deak, Leslie R.
• Application Number:
  US09/799,466
• Publication Number:
  US 20020123712A1
• Time in Patent Office: 953 Days
• Field of Search: 604/4.01, 604/5.01, 604/28, 604/506, 604/507, 604/29, 604/27, 604/6.09, 604/9, 604/6.01, 604/6.11, 604/6.12, 604/6.04, 604/5.04, 210/646
• US Class Current: 604/6.04
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3482 by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
• CPC Class Codes: B01D 2313/243 Pumps
• CPC Class Codes: B01D 2313/60 Specific sensors or sensor arrangements
• CPC Class Codes: B01D 2313/90 Additional auxiliary systems integrated with the module or apparatus
• CPC Class Codes: B01D 2313/903 Integrated control or detection device
• CPC Class Codes: B01D 61/146 comprising multiple ultrafiltration steps
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/22 Controlling or regulating
• CPC Class Codes: B01D 63/024 with a single potted end

Abstract

Segmental edema is treated by inserting a plasma extraction filter device in a major vein of a body segment or servicing the body segment containing the edemic tissues, and inserting a return catheter in a major artery of the body segment affected or feeding the body segment from which plasma is extracted. Blood plasma and plasma proteins extracted from the edemic body segment through the plasma extraction filter fluids are directed to an ultrafiltration apparatus where plasma water is separated from the plasma proteins. Plasma proteins are returned to the body segment from which the plasma was extracted via the return catheter in the major artery of the subject body segment.

Claims

1. A method of treating segmental edema in a patient comprising:

inserting a plasma extraction device in a major vein proximal to a body segment containing edemic tissue, said plasma extraction device comprising a plasma extraction filter capable of separating plasma including plasma proteins from blood in-vivo within said vein and a plasma extraction catheter for directing separated plasma from the plasma extraction filter to an ultrafiltration apparatus;

inserting a return catheter in a major artery of the body segment from which the plasma is extracted;

separating and extracting plasma and plasma proteins from blood in the major vein through said plasma extraction filter;

directing the extracted plasma through the plasma extraction catheter to an ultrafiltration apparatus and separating plasma water from plasma proteins therein, and collecting and/or discarding the separated plasma water; and

directing plasma proteins via the return catheter to the major artery of the body segment of the patient from which the plasma is extracted.

2. The method of claim 1 including directing separated plasma water from the ultrafiltration apparatus to a collection container via a plasma water line.

3. The method of claim 1 comprising pumping extracted plasma from the plasma extraction filter to the ultrafiltration apparatus.

4. The method of claim 2 comprising pumping extracted plasma from the plasma extraction filter to the ultrafiltration apparatus.

5. The method of claim 1, 2, 3 or 4 comprising pumping plasma proteins from the ultrafiltration apparatus to the major artery.

6. The method of claim 5 comprising pumping plasma water from the ultrafiltration apparatus to a collection container.

7. The method of claim 5 including sensing pressure in the plasma extraction catheter and the plasma water line and in response thereto controlling the amount and rate of plasma extraction and plasma water separation.

8. The method of claim 7 comprising controlling the pumping of the extracted plasma and separated plasma water in response to pressure sensed in the plasma extraction catheter and plasma water line.

9. The method of claim 7 including directing amounts of plasma proteins to the patient via the return catheter different than amounts extracted through the plasma extraction filter.

10. The method of claim 5 including directing amounts of plasma proteins to the patient via the return catheter different than amounts extracted through the plasma extraction filter.

11. The method of claim 10 wherein at least a portion of the plasma protein extracted from the patient is returned to the patient.

12. The method of claim 1, 23 or 4 comprising pumping plasma water from the ultrafiltration apparatus to a collection container.

13. The method of claim 1 including sensing pressure in the plasma extraction catheter.

14. The method of claim 1 including selectively directing separated plasma proteins to a collection container.

15. The method of claim 1 wherein at least a portion of the plasma protein extracted from the patient is returned to the patient.

16. The method of claim 1 wherein the plasma extraction device is inserted in the iliac or femoral vein and the return catheter is inserted in the iliac or femoral artery.

17. A method of treating segmental edema in a patent comprising:

inserting a plasma water extraction device in a major vein proximal to a body segment containing edemic tissue, said plasma water extraction device comprising an ultrafiltration membrane capable of separating plasma water from blood and plasma protein in-vivo within said vein and a plasma water extraction catheter for directing separated plasma water from the plasma water extraction membrane;

inserting a return catheter in a major artery of the body segment from which the plasma water is extracted;

separating plasma water from blood in-vivo in the major vein through said ultrafiltration membrane and directing the separated plasma water from the vein via the plasma water extraction catheter to a plasma water container; and

directing plasma protein via the return catheter to the major artery of the body segment of the patient from which the plasma water is extracted.

18. The method of claim 17 wherein the location of the inserted plasma water extraction device is elevated relative to the position of the plasma water container, wherein the method includes:

observing the rate of plasma water collected in the plasma water container and adjusting or controlling the rate by raising or lowering the container relative to the plasma extraction device.