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Continuous polymerase chain reaction apparatus with multiple temperature stations

  • US 6,632,653 B1
  • Filed: 12/13/1999
  • Issued: 10/14/2003
  • Est. Priority Date: 12/08/1997
  • Status: Expired due to Term
First Claim
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1. An apparatus for performing a reagent protocol using polymerase chain reaction, comprising:

  • (a) means to index patterns of reagent wells on a continuous basis through at least one step of reagent addition to said reagent wells;

    (b) means to index said patterns of reagent wells on a continuous basis through a plurality of individual heat transfer stations, whereby at each of said individual heat transfer stations, said patterns of reagent wells are subjected to a unique temperature change to cause one amplification step, with said plurality of individual heat transfer stations providing total amplification required for said protocol; and

    (c) means to seal said reagent wells following said at least one step of reagent addition to said wells, wherein said patterns of reagent wells are sealed to provide a liquid tight but peelable seal as provided by pressure sensitive adhesive or heat seal methods.

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