Electrodes and method for manufacturing electrodes for electrically assisted drug delivery
First Claim
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1. A method for making an electrode assembly for electrically assisted transmembrane delivery of an active ingredient, comprising the steps of:
- a. providing an unloaded electrode assembly comprising a Ag/AgCl electrode and a reservoir comprising a polymer having an aqueous composition dispersed therein, the aqueous composition comprising an amount of salt effective to inhibit electrode corrosion; and
b. contacting a surface of the reservoir with an aqueous loading solution comprising an active electrode-corrosive ingredient for an amount of time effective to permit loading of a predetermined amount of the active electrode-corrosive ingredient into the reservoir.
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Abstract
Provided is a method for loading electrode-corroding ingredients into an un-loaded donor gel reservoir of an electrode for an electrically assisted drug delivery system. The method provides that a salt, such as sodium chloride or an organic salt, is provided in the un-loaded donor gel reservoir, contrary to convention. Related electrically assisted drug delivery electrode assemblies also are provided.
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Citations
19 Claims
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1. A method for making an electrode assembly for electrically assisted transmembrane delivery of an active ingredient, comprising the steps of:
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a. providing an unloaded electrode assembly comprising a Ag/AgCl electrode and a reservoir comprising a polymer having an aqueous composition dispersed therein, the aqueous composition comprising an amount of salt effective to inhibit electrode corrosion; and
b. contacting a surface of the reservoir with an aqueous loading solution comprising an active electrode-corrosive ingredient for an amount of time effective to permit loading of a predetermined amount of the active electrode-corrosive ingredient into the reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
about 30% wt. lidocaine HCl;
about 0.57% wt. L-epinephrine bitartrate; and
about 0.06% to about 0.9% wt. NaCl.
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11. The method of claim 10, in which the loading solution further comprises a chelating agent;
- a humectant, and an antioxidant.
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12. The method of claim 1, wherein the reservoir comprises about 24% wt. ±
- 1% wt. of a polyvinylpyrrolidone hydrogel and about 0.06% wt. NaCl and wherein the reservoir is contacted with about 33% wt. ±
10% wt. of a loading solution, comprising;about 30% wt. lidocaine HCl;
about 0.57% wt. L-epinephrine bitartrate; and
about 0.06% wt. to about 0.9% wt. NaCl.
- 1% wt. of a polyvinylpyrrolidone hydrogel and about 0.06% wt. NaCl and wherein the reservoir is contacted with about 33% wt. ±
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13. The method of claim 12, wherein the loading solution further comprises:
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about 0.03% wt. EDTA;
about 0.06% wt. citric acid;
about 30% wt. glycerin; and
about 0.15% wt. sodium metabisulfite.
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14. The method of claim 1 in which the loading solution comprises:
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about 30% wt. lidocaine HCl;
about 0.57% wt. L-epinephrine bitartrate;
about 0.06% wt. NaCl;
about 0.03% wt. EDTA;
about 0.06% wt. citric acid;
about 30% wt. glycerin; and
about 0.15% wt. sodium metabisulfite.
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15. An electrode prepared according to a process for preparing the electrode comprising the steps of:
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a. providing an unloaded electrode assembly comprising a Ag/AgCl electrode and a reservoir comprising a polymer having an aqueous composition dispersed therein, the aqueous composition comprising an amount of salt effective to inhibit electrode corrosion; and
b. contacting a surface of the reservoir with an aqueous loading solution comprising an active electrode-corrosive ingredient for an amount of time effective to permit loading of a predetermined amount of the active electrode-corrosive ingredient into the reservoir. - View Dependent Claims (16, 17, 18, 19)
about 30% wt. lidocaine HCl;
about 0.57% wt. L-epinephrine bitartrate; and
about 0.06% wt. to about 0.9% wt. NaCl.
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17. the electrode of claim 15, in which the loading solution further comprises a chelating agent, a humectant and an antioxidant.
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18. The electrode of claim 15, wherein the loading solution comprises:
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about 30% wt. lidocaine HCl;
about 0.57% wt. L-epinephrine bitartrate; and
about 0.06% wt. NaCl.
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19. The electrode assembly of claim 18, wherein the loading solution further comprises:
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about 0.03% wt. EDTA;
about 0.06% wt. citric acid;
about 30% wt. glycerin; and
about 0.15% wt. sodium metabisulfite.
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Specification
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Current AssigneeVyteris, Inc.
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Original AssigneeVyteris, Inc.
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InventorsFalevich, Vitaly, Jain, Uday K., Carey, Kevin John, Eliash, Bruce M., Reddy, Vilambi Nrk, Keusch, Preston
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Primary Examiner(s)Bennett, Henry
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Application NumberUS09/897,698Publication NumberTime in Patent Office844 DaysField of Search604/20, 604/501, 604/890.1, 604/62, 604/49, 607/153, 607/152, 607/149, 607/115, 424/449, 424/448, 424/78.12, 514/772US Class Current604/501CPC Class CodesA61N 1/0436 Material of the electrodeA61N 1/0448 Drug reservoirA61P 9/04 Inotropic agents, i.e. stim...
