Sustained delivery of an active agent using an implantable system
First Claim
1. An implantable device for delivering an active agent to a fluid environment of use for a predetermined administration period of at least 2 months, said device comprising a reservoir and a back-diffusion regulating outlet in mating relationship, wherein a flow path for the active agent comprises a pathway formed between the mating surfaces of the reservoir and the back-diffusion regulating outlet.
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Accused Products
Abstract
The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
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Citations
20 Claims
- 1. An implantable device for delivering an active agent to a fluid environment of use for a predetermined administration period of at least 2 months, said device comprising a reservoir and a back-diffusion regulating outlet in mating relationship, wherein a flow path for the active agent comprises a pathway formed between the mating surfaces of the reservoir and the back-diffusion regulating outlet.
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10. An implantable active agent delivery system for delivering an active agent to a fluid environment of use for a predetermined administration period of at least 2 months, said agent being susceptible to degradation if exposed to the fluid environment of use prior to delivery, said system comprising:
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(a) a piston that divides the system into a first and second chamber, the first and second chambers each having an open end;
(b) a water-swellable agent formulation in the first chamber;
(c) an active agent formulation in the second chamber;
(d) a semipermeable plug in the open end of the first chamber; and
(e) a back-diffusion regulating outlet in the open end of the second chamber;
wherein said system effectively seals and isolates the active agent chamber from the environment of use. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An implantable active agent delivery system for delivering an active agent to a fluid environment of use at a steady state flow rate of at least 70% of an intended flow rate after start-up, said agent being susceptible to degradation if exposed to the fluid environment of use prior to delivery, said system comprising:
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(a) a piston that divides the system into a first and second chamber, the first and second chambers each having an open end;
(b) a water-swellable agent formulation in the first chamber;
(c) an active agent formulation in the second chamber;
(d) a semipermeable plug in the open end of the first chamber; and
(e) a back-diffusion regulating outlet in the open end of the second chamber;
wherein said system effectively seals and isolates the active agent chamber from the environment of use.
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Specification