Multi-imaging modality tissue mimicking materials for imaging phantoms

• US 6,635,486 B2
• Filed: 07/27/2001
• Issued: 10/21/2003
• Est. Priority Date: 07/14/1999
• Status: Expired due to Term

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Frank, Gary R., Madsen, Ernest L., DʼSouza, Warren D.
• Primary Examiner(s): WALLENHORST, MAUREEN
• Application Number:
  US09/916,683
• Publication Number:
  US 20020012999A1
• Time in Patent Office: 816 Days
• Field of Search: 436/8, 73/18.6, 73/18.2, 738/664, 324/308, 324/309
• US Class Current: 436/8
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/587 Calibration phantoms models for medical purposes G09B23/28
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Tissue-mimicking material suitable for phantoms for use with at least ultrasound and MRI have sections of material in contact with each other which mimic ultrasound and magnetic resonance imaging properties of human tissues, and preferably also computed tomography properties, so that the phantom can be used for the testing of imaging by various types of medical imagers. A suitable tissue-mimicking material for use in phantoms of this type includes an aqueous mixture of large organic water soluble molecules, a copper salt, a chelating agent for binding the copper ions in the salt, and a gel-forming material. Small glass beads may be intermixed therewith to provide a selected ultrasound attenuation coefficient without substantially affecting the MRI properties of the material. Larger glass beads may be used in a section to control primarily the ultrasound backscatter coefficient without significant effect on the ultrasound attenuation coefficient. Tissue-mimicking material that simulates muscle may have smaller glass beads and a higher concentration of gel-forming material than an adjacent section. Such similar materials in contact with one another show relative stability over extended periods of time.

Claims

1. Multimodality tissue-mimicking material for phantoms that simulates fatty tissue comprising:

an open cell mesh with interstices therein, the mesh holding oil, and oil absorbed in and held in the interstices of the mesh, wherein the material is in direct contact with a gel-forming material.

2. The tissue-mimicking material of claim 1 wherein the open cell mesh comprises polyurethane.

5. The tissue-mimicking material of claim 1 wherein the speed of sound in the material is the same as the speed of sound in fatty tissue.

6. The tissue-mimicking material of claim 1 wherein the ultrasonic attenuation of the material is the same as the ultrasonic attenuation of fatty tissue.

7. The tissue-mimicking material of claim 1 wherein the computed tomography number for the material is the same as the computed tomography number found in fatty tissue.

8. The tissue-mimicking material of claim 1 wherein the magnetic resonance imaging relaxation times of the material are the same as the magnetic resonance imaging relaxation times found in fatty tissue.

3. The tissue-mimicking material of wherein the oil is vegetable oil.

4. The tissue-mimicking material of claim 3 wherein the vegetable oil is safflower oil.

9. Multimodality tissue-mimicking material for phantoms that simulates fatty tissue comprising:

an open cell mesh with interstices therein, the mesh holding oil, and oil absorbed in and held in the interstices of the mesh; and

a phantom container, the tissue-mimicking material at least partially filling the phantom container.

10. The tissue-mimicking material of claim 9 wherein the open cell mesh comprises polyurethane.

11. The tissue-mimicking material at claim 9 wherein the oil is vegetable oil.

12. The tissue-mimicking material of claim 11 wherein the vegetable oil is safflower oil.

13. The tissue-mimicking material of claim 9 wherein the speed of sound in the material is the same as the speed of sound in fatty tissue.

14. The tissue-mimicking material of claim 9 wherein the ultrasonic attenuation of the material is the same as the ultrasonic attenuation of fatty tissue.

15. The tissue-mimicking material of claim 9 wherein the computed tomography number for the material is the same as the computed tomography number found in fatty tissue.

16. The tissue-mimicking material of claim 9 wherein the magnetic resonance imaging relaxation times of the material are the same as the magnetic resonance imaging relaxation times found in fatty tissue.

17. The tissue-mimicking material of claim 9 wherein the phantom container includes an ultrasound transmitting window cover.

18. The tissue-mimicking material of claim 17 wherein the ultrasound transmitting window cover comprised plastic.

19. The tissue-mimicking material of claim 17 wherein the ultrasound transmitting window cover comprises polyurethane.

20. The tissue-mimicking material of claim 9 wherein the container is fluid tight.

21. The tissue-mimicking material of claim 20 wherein the container includes a window cover coated with a layer of an oil-based gel.