Monocyclic-7H-pyrrolo[2,3-d]pyrimidine compounds, compositions, and methods of use
First Claim
Patent Images
1. A compound of the formula or the pharmaceutically acceptable salt thereof;
- whereinR1 is a group of the formula
whereinm is 0, 1, 2 or 3;
n is 0, 1, 2 or 3;
X, B and D are each CR7R8;
A and E are each CR7R8; and
R7 and R8 are each independently selected from the group consisting of hydrogen, deuterium, (C1-C6)alkyl, amino, hydroxy, (C1-C6)alkoxy, (C1-C6)alkylamino, ((C1-C6)alkyl)amino, (C1-C6)acylamino, (C1-C6)acyl(C1-C6)alkylamino, (C1-C6)alkoxyacyl, (C1-C6)alkylaminoacyl, ((C1-C6)alkyl)2aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C1-C6)alkyl, (C1-C6)alkyl (difluoromethylene), (C1-C3)alkyl(difluoromethylene)(C1-C3)alkyl, (C6-C10)aryl, (C5-C9)heteroaryl, (C6-C10)aryl(C1-C6)alkyl, (C5-C9)heteroaryl(C1-C6)alkyl, (C6-C10)aryl(C6-C10)aryl, (C6-C10)aryl(C6-C10)aryl(C1-C6)alkyl, (C3-C6)cycloalhyl, (C3-C6)cycloalkyl(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)acyloxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, piperazinyl(C1-C6)alkyl, (C1-C6)acylamino(C1-C6)alkyl, piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)aryl(C1-C6)alkoxy(C1-C6)alkyl, (C5-C9)heteroaryl(C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkylthio(C1-C6)alkyl, (C6-C10)arylthio(C1-C6)alkyl, (C1-C6)alkylsulfinyl(C1-C6)alkyl, (C6-C10)arylsulfinyl(C1-C6)alkyl, (C1-C6)alkylsulfonyl(C1-C6)alkyl, (C6-C10)arylsulfonyl(C1-C6)alkyl, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, ((C1-C6)alkyl)2amino(C1-C6)alkyl, R13CO(C1-C6)alkyl, R13CO(C3-C10)cycloalkyl, wherein R13 is R20O or R20R21N wherein R20 and R21 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C6-C10)aryl(C1-C6)alkyl and (C5-C9)heteroaryl(C1-C6)alkyl, R14, R14(C1-C6)alkyl, R14(C3-C10)cycloalkyl, wherein R14 is (C1-C6)acylpiperazino, (C6-C10)arylpiperazino, (C5-C9)heteroarylpiperazino, (C1-C6)alkylpiperazino, (C6-C10)aryl(C1-C6)alkylpiperazino, (C5-C9)heteroaryl(C1-C6)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)arylpiperidyl, (C5-C9)heteroarylpiperidyl, (C6-C10)aryl(C1-C6)alkylpiperidyl, (C5-C9)heteroaryl(C1-C6)alkylpiperidyl or (C1-C6)acylpiperidyl, or a group of the formulawhereinp is 0, 1, 2 or 3; and
Z is hydroxy, (C1-C6)alkoxy or NR1R2 wherein R1 and R2 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)arylpiperidyl, (C5-C9)heteroarylpiperidyl, (C6-C10)aryl(C1-C6)alkylpiperidyl, (C5-C9)heteroaryl(C1-C6)alkylpiperidyl, (C1-C6)acylpiperidyl, (C6-C10)aryl, (C5-C9)heteroaryl, (C6-C10)aryl(C1-C6)alkyl, (C5-C9)heteroaryl(C1-C6)alkyl, (C6-C10)aryl(C6-C10)aryl, (C6-C10)aryl(C6-C10)aryl(C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, R5(C1-C6)alkyl, (C1-C5)alkyl(CHR5)(C1-C6)alkyl, wherein R5 is hydroxy, (C1-C6)acyloxy, (C1-C6)alkoxy, piperazino, (C1-C6)acylamino, (C1-C6)alkylthio, (C6-C10)arylthio, (C1-C6)alkylsulfinyl, (C6-C10)arylsulfinyl, (C1-C6)alkylsulfoxyl, (C6-C10)arylsulfoxyl, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2 amino, (C1-C6)acylpiperazino, (C1-C6)alkylpiperazino, (C6-C10)aryl(C1-C6)alkylpiperazino, (C5-C9)heteroaryl(C1-C6)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino, and R6(C1-C6)alkyl, (C1-C5)alkyl(CHR6)(C1-C6)alkyl, wherein R6 is piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)arylpiperidyl, (C6-C10)aryl(C1-C6)alkylpiperidyl, (C5-C9)heteroarylpiperidyl or (C5-C9)heteroaryl(C1-C6)alkylpiperidyl;
R2 and R3 are each independently selected from the group consisting of hydrogen, deuterium, amino, halo, hydoxy, nitro, carboxy, (C2-C6)alkenyl, (C2-C6)alkynyl, trifluoromethyl, trifluoromethoxy, (C1-C6)alkyl, and (C1-C6)alkoxy wherein the alkyl or alkoxy groups are optionally substittued by one to three groups selected from halo, hydroxy, carboxy, amino (C1-C6)alkylthio, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C5-C9)heteroaryl, (C2-C9)heterocycloalkyl, (C3-C9)cycloalkyl or (C6-C10)aryl;
or R2 and R3 are each independently (C3-C10)cycloalkyl, (C3-C10)cycloalkoxy, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C6-C10)arylamino, (C1-C6)alkylthio, (C6-C10)arylthio, (C1-C6)alkylsulfinyl, (C6-C10)arylsulfinyl, (C1-C6)alkylsulfonyl, (C6-C10)arylsulfonyl, (C1-C6)acyl, (C1-C6)alkoxy-CO—
NH—
, (C1-C6)alkyamino-CO—
, (C5-C9)heteroaryl, (C2-C9)heterocycloalkyl or (C6-C10)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C1-C6)alkyl, (C1-C6)alkyl-CO—
NH—
, (C1-C6)alkoxy-CO—
NH—
, (C1-C6)alkyl-CO—
NH—
(C1-C6)alkyl, (C1-C6)alkoxy-CO—
NH—
(C1-C6)alkyl, (C1-C6)alkoxy-CO—
NH—
(C1-C6)alkoxy, carboxy, carboxy(C1-C6)alkyl, carboxy(C1-C6)alkoxy, benzyloxycarbonyl(C1-C6)alkoxy, (C1-C6)alkoxycarbonyl(C1-C6)alkoxy, (C6-C10)aryl, amino, amino(C1-C6)alkyl, (C1-C6)alkoxycarbonylamino, (C6-C10)aryl(C1-C6)alkoxycarbonylamino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C1-C6)alkylamino(C1-C6)alkyl, ((C1-C6)alkyl)2amino(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, carboxy, carboxy(C1-C6)alkyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkoxycarbonyl(C1-C6)alkyl, (C1-C6)alkoxy-CO—
NH—
, (C1-C6)alkyl-CO—
NH—
, cyano, (C5-C9)heterocycloalkyl, amino-CO—
NH—
, (C1-C6)alkylamino-CO—
NH—
, ((C1-C6)alkyl)2amino-CO—
NH—
, (C6-C10)arylamino-CO—
NH—
, (C5-C9)heteroarylamino-CO—
NH—
, (C1-C6)alkylamino-CO—
NH—
(C1-C6)alkyl, ((C1-C6)alkyl)2amino-CO—
NH—
(C1-C6)alkyl, (C6-C10)arylamino-CO—
NH—
(C1-C6)alkyl, (C5-C9)heteroarylamino-CO—
NH—
(C1-C6)alkyl, (C1-C6)alkylsulfonyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C6-C10)arylsulfonyl, (C6-C10)arylsulfonylamino, (C6-C10)arylsulfonylamino(C1-C6)alkyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C5-C9)heteroaryl or (C2-C9)heterocycloalkyl;
with the proviso that when R2 and R3 are each independently hydrogen or (C1-C6)alkyl, R1 cannot be unsubstituted piperidinyl; and
with the proviso that when R2 and R3 are each hydrogen, R1 cannot be unsubstituted pyrrolidinyl.
1 Assignment
0 Petitions
Accused Products
Abstract
Novel pyrrolo[2,3-d]pyrimidine compounds useful as inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 as well as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn'"'"'s disease, Alzheimer'"'"'s disease, Leukemia and other autoimmune diseases are described.
-
Citations
3 Claims
-
1. A compound of the formula
or the pharmaceutically acceptable salt thereof; - wherein
R1 is a group of the formula wherein m is 0, 1, 2 or 3;
n is 0, 1, 2 or 3;
X, B and D are each CR7R8;
A and E are each CR7R8; and
R7 and R8 are each independently selected from the group consisting of hydrogen, deuterium, (C1-C6)alkyl, amino, hydroxy, (C1-C6)alkoxy, (C1-C6)alkylamino, ((C1-C6)alkyl)amino, (C1-C6)acylamino, (C1-C6)acyl(C1-C6)alkylamino, (C1-C6)alkoxyacyl, (C1-C6)alkylaminoacyl, ((C1-C6)alkyl)2aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C1-C6)alkyl, (C1-C6)alkyl (difluoromethylene), (C1-C3)alkyl(difluoromethylene)(C1-C3)alkyl, (C6-C10)aryl, (C5-C9)heteroaryl, (C6-C10)aryl(C1-C6)alkyl, (C5-C9)heteroaryl(C1-C6)alkyl, (C6-C10)aryl(C6-C10)aryl, (C6-C10)aryl(C6-C10)aryl(C1-C6)alkyl, (C3-C6)cycloalhyl, (C3-C6)cycloalkyl(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)acyloxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, piperazinyl(C1-C6)alkyl, (C1-C6)acylamino(C1-C6)alkyl, piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)aryl(C1-C6)alkoxy(C1-C6)alkyl, (C5-C9)heteroaryl(C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkylthio(C1-C6)alkyl, (C6-C10)arylthio(C1-C6)alkyl, (C1-C6)alkylsulfinyl(C1-C6)alkyl, (C6-C10)arylsulfinyl(C1-C6)alkyl, (C1-C6)alkylsulfonyl(C1-C6)alkyl, (C6-C10)arylsulfonyl(C1-C6)alkyl, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, ((C1-C6)alkyl)2amino(C1-C6)alkyl, R13CO(C1-C6)alkyl, R13CO(C3-C10)cycloalkyl, wherein R13 is R20O or R20R21N wherein R20 and R21 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C6-C10)aryl(C1-C6)alkyl and (C5-C9)heteroaryl(C1-C6)alkyl, R14, R14(C1-C6)alkyl, R14(C3-C10)cycloalkyl, wherein R14 is (C1-C6)acylpiperazino, (C6-C10)arylpiperazino, (C5-C9)heteroarylpiperazino, (C1-C6)alkylpiperazino, (C6-C10)aryl(C1-C6)alkylpiperazino, (C5-C9)heteroaryl(C1-C6)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)arylpiperidyl, (C5-C9)heteroarylpiperidyl, (C6-C10)aryl(C1-C6)alkylpiperidyl, (C5-C9)heteroaryl(C1-C6)alkylpiperidyl or (C1-C6)acylpiperidyl, or a group of the formula wherein p is 0, 1, 2 or 3; and
Z is hydroxy, (C1-C6)alkoxy or NR1R2 wherein R1 and R2 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)arylpiperidyl, (C5-C9)heteroarylpiperidyl, (C6-C10)aryl(C1-C6)alkylpiperidyl, (C5-C9)heteroaryl(C1-C6)alkylpiperidyl, (C1-C6)acylpiperidyl, (C6-C10)aryl, (C5-C9)heteroaryl, (C6-C10)aryl(C1-C6)alkyl, (C5-C9)heteroaryl(C1-C6)alkyl, (C6-C10)aryl(C6-C10)aryl, (C6-C10)aryl(C6-C10)aryl(C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, R5(C1-C6)alkyl, (C1-C5)alkyl(CHR5)(C1-C6)alkyl, wherein R5 is hydroxy, (C1-C6)acyloxy, (C1-C6)alkoxy, piperazino, (C1-C6)acylamino, (C1-C6)alkylthio, (C6-C10)arylthio, (C1-C6)alkylsulfinyl, (C6-C10)arylsulfinyl, (C1-C6)alkylsulfoxyl, (C6-C10)arylsulfoxyl, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2 amino, (C1-C6)acylpiperazino, (C1-C6)alkylpiperazino, (C6-C10)aryl(C1-C6)alkylpiperazino, (C5-C9)heteroaryl(C1-C6)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino, and R6(C1-C6)alkyl, (C1-C5)alkyl(CHR6)(C1-C6)alkyl, wherein R6 is piperidyl, (C1-C6)alkylpiperidyl, (C6-C10)arylpiperidyl, (C6-C10)aryl(C1-C6)alkylpiperidyl, (C5-C9)heteroarylpiperidyl or (C5-C9)heteroaryl(C1-C6)alkylpiperidyl;
R2 and R3 are each independently selected from the group consisting of hydrogen, deuterium, amino, halo, hydoxy, nitro, carboxy, (C2-C6)alkenyl, (C2-C6)alkynyl, trifluoromethyl, trifluoromethoxy, (C1-C6)alkyl, and (C1-C6)alkoxy wherein the alkyl or alkoxy groups are optionally substittued by one to three groups selected from halo, hydroxy, carboxy, amino (C1-C6)alkylthio, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C5-C9)heteroaryl, (C2-C9)heterocycloalkyl, (C3-C9)cycloalkyl or (C6-C10)aryl;
or R2 and R3 are each independently (C3-C10)cycloalkyl, (C3-C10)cycloalkoxy, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C6-C10)arylamino, (C1-C6)alkylthio, (C6-C10)arylthio, (C1-C6)alkylsulfinyl, (C6-C10)arylsulfinyl, (C1-C6)alkylsulfonyl, (C6-C10)arylsulfonyl, (C1-C6)acyl, (C1-C6)alkoxy-CO—
NH—
, (C1-C6)alkyamino-CO—
, (C5-C9)heteroaryl, (C2-C9)heterocycloalkyl or (C6-C10)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C1-C6)alkyl, (C1-C6)alkyl-CO—
NH—
, (C1-C6)alkoxy-CO—
NH—
, (C1-C6)alkyl-CO—
NH—
(C1-C6)alkyl, (C1-C6)alkoxy-CO—
NH—
(C1-C6)alkyl, (C1-C6)alkoxy-CO—
NH—
(C1-C6)alkoxy, carboxy, carboxy(C1-C6)alkyl, carboxy(C1-C6)alkoxy, benzyloxycarbonyl(C1-C6)alkoxy, (C1-C6)alkoxycarbonyl(C1-C6)alkoxy, (C6-C10)aryl, amino, amino(C1-C6)alkyl, (C1-C6)alkoxycarbonylamino, (C6-C10)aryl(C1-C6)alkoxycarbonylamino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C1-C6)alkylamino(C1-C6)alkyl, ((C1-C6)alkyl)2amino(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, carboxy, carboxy(C1-C6)alkyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkoxycarbonyl(C1-C6)alkyl, (C1-C6)alkoxy-CO—
NH—
, (C1-C6)alkyl-CO—
NH—
, cyano, (C5-C9)heterocycloalkyl, amino-CO—
NH—
, (C1-C6)alkylamino-CO—
NH—
, ((C1-C6)alkyl)2amino-CO—
NH—
, (C6-C10)arylamino-CO—
NH—
, (C5-C9)heteroarylamino-CO—
NH—
, (C1-C6)alkylamino-CO—
NH—
(C1-C6)alkyl, ((C1-C6)alkyl)2amino-CO—
NH—
(C1-C6)alkyl, (C6-C10)arylamino-CO—
NH—
(C1-C6)alkyl, (C5-C9)heteroarylamino-CO—
NH—
(C1-C6)alkyl, (C1-C6)alkylsulfonyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C6-C10)arylsulfonyl, (C6-C10)arylsulfonylamino, (C6-C10)arylsulfonylamino(C1-C6)alkyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C5-C9)heteroaryl or (C2-C9)heterocycloalkyl;
with the proviso that when R2 and R3 are each independently hydrogen or (C1-C6)alkyl, R1 cannot be unsubstituted piperidinyl; and with the proviso that when R2 and R3 are each hydrogen, R1 cannot be unsubstituted pyrrolidinyl. - View Dependent Claims (3)
- wherein
-
2. A compound selected from the group consisting of:
-
5-Fluoro-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
4-Piperidin-1-yl-5-trifluoromethyl-7H-pyrrolo[2,3-d]pyrimidine;
N,N-Dimethyl-N′
-[3-(4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-benzyl]-ethane-1,2-diamine;
2-[1-(5-m-Tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidin-4-yl]-ethanol;
5-(3-Isopropyl-phenyl)-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
5-(3-Methyl-3H-imidazol-4-yl)-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
5-(1-Methyl-1H-imidazol-4-yl)-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
5-(2-Methyl-pyridin-4-yl)-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
5-Chloro-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
5-Ethynyl-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine;
4-Piperidin-1-yl-5-m-tolyl-7H-pyrrolo[2,3-d]pyrimidine; and
4-(3,3-Dimethyl-piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine;
or a pharmaceutically acceptable salt thereof.
-
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneePfizer Inc., Pfizer Products Incorporated (Pfizer Inc.)
-
Original AssigneePfizer Inc.
-
InventorsBrown, Matthew F., Blumenkopf, Todd A., Flanagan, Mark E., Changelian, Paul S.
-
Primary Examiner(s)Berch, Mark L
-
Application NumberUS09/335,030Time in Patent Office1,587 DaysField of Search544/293, 544/280, 544/117, 544/61, 514/265.1, 514/234.2, 514/228.5US Class Current544/280CPC Class CodesA61P 1/04 for ulcers, gastritis or re...A61P 11/06 AntiasthmaticsA61P 17/04 AntipruriticsA61P 19/02 for joint disorders, e.g. a...A61P 25/00 Drugs for disorders of the ...A61P 25/18 Antipsychotics, i.e. neurol...A61P 25/28 for treating neurodegenerat...A61P 29/00 Non-central analgesic, anti...A61P 3/10 for hyperglycaemia, e.g. an...A61P 35/00 Antineoplastic agentsA61P 35/02 specific for leukemiaA61P 37/00 Drugs for immunological or ...A61P 37/06 Immunosuppressants, e.g. dr...A61P 5/14 of the thyroid hormones, e....A61P 5/16 for decreasing, blocking or...C07D 487/04 Ortho-condensed systems
