Optical sensors for the detection of nitric oxide
First Claim
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1. An optical fiber comprising a fiber tip, said tip comprising an immobilized nitric oxide-binding compound and a fluorescent reference compound.
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Abstract
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity. Additionally, metals functionally linked to reporter dyes are described in addition to the incorporation of reference compounds for ratiometric measurements.
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23 Claims
- 1. An optical fiber comprising a fiber tip, said tip comprising an immobilized nitric oxide-binding compound and a fluorescent reference compound.
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