Apparatus and method for determination of the adequacy of dialysis by non-invasive near-infrared spectroscopy
First Claim
1. A non-invasive method for measuring the concentration of urea in human tissue comprising the steps of:
- providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths, including selected wavelengths relevant to urea concentration due to absorption by said urea, and an input element, said apparatus further including an output element; and
irradiating said tissue through said input element with said multiple wavelengths of infrared energy before, during or after hemodialysis for assessing the need for hemodialysis, the progress of a hemodialysis procedure or the adequacy of the hemodialysis treatment, respectively, and collecting and subsequently measuring at least a portion of the non-absorbed infrared energy with said output element to predict said tissue urea concentration by use of a multivariate algorithm.
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Abstract
Methods and apparatus for non-invasive tissue urea concentrations during or subsequent to hemodialysis using near-infrared spectroscopy are discussed. Near-infrared tissue spectra can be obtained by projecting near-infrared radiation into skin on the underside of human forearms and capturing the light reflected back and out through the tissue. An index matching medium is used to couple the tissue to the analyzer. The tissue spectrum collected preferably includes primarily diffuse reflected light reflected from the inner dermis. Multiple tissue spectra of known urea concentration are used to build a model from which the urea concentration of an unknown sample can be devised. The model is based on a partial least squares algorithm applied to multiple tissue scans and concomitant blood sample urea measurements. This model is then applied to an unknown tissue spectra.
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Citations
7 Claims
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1. A non-invasive method for measuring the concentration of urea in human tissue comprising the steps of:
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providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths, including selected wavelengths relevant to urea concentration due to absorption by said urea, and an input element, said apparatus further including an output element; and
irradiating said tissue through said input element with said multiple wavelengths of infrared energy before, during or after hemodialysis for assessing the need for hemodialysis, the progress of a hemodialysis procedure or the adequacy of the hemodialysis treatment, respectively, and collecting and subsequently measuring at least a portion of the non-absorbed infrared energy with said output element to predict said tissue urea concentration by use of a multivariate algorithm. - View Dependent Claims (2)
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3. A non-invasive method for measuring the concentration of urea in analyte-containing human tissue comprising the steps of:
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providing an optical apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths, including selected wavelengths relevant to urea concentration due to absorption by said urea, operatively connected to an input element, said apparatus further including an output element operatively connected to a spectrum analyzer;
irradiating said tissue through said input element with multiple wavelengths of infrared energy before, during or after hemodialysis for assessing the need for hemodialysis, the progress of a hemodialysis procedure or the adequacy of the hemodialysis treatment, respectively; and
collecting at least a portion of the non-absorbed infrared energy with said output element and measuring the intensity of said non-absorbed energy for analysis with subsequent calculation of tissue urea concentration utilizing a multivariate algorithm. - View Dependent Claims (4, 5, 6, 7)
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Specification