Stable shaped particles of crystalline organic compounds
First Claim
1. A plurality of storage stable particles of uniform shape consisting essentially of a plurality of allotropic organic compounds wherein each of said allotropic organic compounds consists of a uniform crystalline character and each of said allotropic organic compounds has a plurality of crystalline domains in said particle.
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Abstract
The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.
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9 Claims
- 1. A plurality of storage stable particles of uniform shape consisting essentially of a plurality of allotropic organic compounds wherein each of said allotropic organic compounds consists of a uniform crystalline character and each of said allotropic organic compounds has a plurality of crystalline domains in said particle.
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