Reducing adhesion
First Claim
Patent Images
1. A device for insertion into a body to reduce adhesion, comprising:
- a sheet comprising ionically cross-linked alginate and having sufficient mechanical stability to allow suturing of the sheet to a body tissue, the sheet providing a barrier to reduce adhesion between the body tissue and a neighboring body tissue.
2 Assignments
0 Petitions
Accused Products
Abstract
A method of reducing adhesion at a site of trauma includes forming a film from an alginate solution, contacting the film with a cross-linking solution to form a cross-linked mechanically stable sheet, and placing at least a portion of the sheet at the site of trauma. An anti-adhesion barrier includes a sheet of ionically cross-linked alginate having a thickness in a range of 0.25 mm to 10 mm. The sheet has a tear strength sufficient for suturing and repositioning. A drug delivery device includes a cross-linked alginate container that can be filled with a drug.
63 Citations
70 Claims
-
1. A device for insertion into a body to reduce adhesion, comprising:
- a sheet comprising ionically cross-linked alginate and having sufficient mechanical stability to allow suturing of the sheet to a body tissue, the sheet providing a barrier to reduce adhesion between the body tissue and a neighboring body tissue.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
25. A drug delivery device for insertion in a body, comprising:
- a container comprising mechanically stable ionically cross-linked alginate, wherein the container can be inserted into a body after being filled with one or more drugs.
- View Dependent Claims (26, 27)
-
28. A method of forming a sheet for use as an adhesion barrier, comprising:
-
forming a film from an alginate solution; and
contacting the film with a cross-linking solution to form a cross-linked mechanically stable sheet for placement of at least a portion of the sheet at a site of trauma to create the adhesion barrier. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
-
-
67. A method of making a drug delivery device for insertion in a body, comprising:
-
forming a film from an alginate solution;
contacting the film with a cross-linking solution to cross-link an exterior portion of the film; and
draining a substantially non-cross-linked interior portion of the film through an opening in the exterior portion to leave the exterior portion defining an interior space for filling with one or more drugs and insertion in the body. - View Dependent Claims (68)
-
-
69. A method of reducing adhesion at a site of trauma, comprising:
-
disposing a film of alginate solution at the site of trauma; and
contacting the film disposed at the site of trauma with a cross-linking solution to form a cross-linked alginate barrier layer.
-
-
70. A method for reduction of adhesion at a site of trauma, comprising:
-
disposing a film of cross-linking solution at the site of trauma; and
contacting the film disposed at the site of trauma with an alginate solution to form a cross-linked alginate barrier layer.
-
Specification