drug delivery systems and methods

• US 6,641,565 B1
• Filed: 11/12/1999
• Issued: 11/04/2003
• Est. Priority Date: 11/13/1998
• Status: Expired due to Fees

• Current Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Original Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Inventors: Lavi, Gilad, Tsals, Izrail, Gross, Joseph, Yigal, Gil
• Primary Examiner(s): Hayes, Michael J.
• Assistant Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US09/439,725
• Time in Patent Office: 1,453 Days
• Field of Search: 604/518, 604/82, 604/87, 604/88, 604/89, 604/91, 604/191, 604/200, 604/201, 604/203-205, 604/181, 604/187, 604/183, 604/232, 604/234, 604/235, 604/259, 604/411-415, 141/25-27, 141/22, 141/105, 141/265, 141/107, 141/369, 141/250, 141/329, 141/375, 141/382-383
• US Class Current: 604/183
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2017 having three or more piercing ends
• CPC Class Codes: A61J 1/2051 having tap means, e.g. tap means activated by sliding
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2082 for gas filtration
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2005/3223 Means impeding or disabling repositioning of used needles at the syringe nozzle
• CPC Class Codes: A61M 2205/215 Tilt detection, e.g. for warning or shut-off
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/2448 : comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3234 : Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user

Abstract

The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.

Claims

1. A liquid drug transfer system comprising:

a housing;

a port in said housing that receives a container, and whereby said port passes a liquid from said container as the container is displaced within said port;

a delivery device that can be connected to the housing to receive the liquid from the container via said port; and

a latching mechanism that latches said delivery device to said container during drug transfer and then disengages said delivery device once the container has reached an end of travel in said port.

2. The liquid drug transfer system of claim 1 further comprising a pressurizing mechanism that pressurizes the container.

3. The liquid transfer system of claim 1 further comprising a locking mechanism to secure the container in the housing.

4. The liquid drug transfer system of claim 1 wherein the delivery device comprises a detachable housing having a needle having a storage position within the detachable housing and an operating position that extends through an aperture in the detachable housing.

5. The liquid drug transfer system of claim 1 wherein the port further comprises a manifold having a channel through which liquid is transferred from the container to the delivery device.

6. The liquid drug transfer system of claim 1 further comprising a support surface on the housing such that a user can insert the container with one hand while the housing is positioned with the support surface.

7. A method for transferring a liquid comprising:

inserting a container in a housing having a port;

latching a delivery device to the container;

transferring a liquid in the container through said port in said housing to a delivery device as the container is moved within said port, and;

disengaging said delivery device from the container only after the container has reached an end of travel in said port.

8. The method of claim 7 further comprising actuating a pressurizing mechanism that pressurizes the container.

9. The method of claim 7 further comprising providing a locking mechanism to secure the container in the housing.

10. The method of claim 7 further comprising providing a manifold in the having a first channel that connects the container to the delivery device.