Hydrophilic polymeric material for coating biosensors
First Claim
1. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising a chain extender and:
- (a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 900 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000.
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Accused Products
Abstract
Disclosed is a biocompatible membrane comprising a hydrophilic polyurea composition. The hydrophilic polyurea composition comprises the product of a reaction mixture comprising (a) an amino terminated polysiloxane, (b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight of from about 400 to about 2000, and (c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture. In this mixture, (a) and (b) constitute a polymeric portion of the reaction mixture, and the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from about 2,000 to about 10,000. Also provided are biosensors coated with a membrane of the invention, and methods of using such biosensors to measure an analyte in a tissue of a subject.
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Citations
31 Claims
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1. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising a chain extender and:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 900 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture and a second reaction mixture:
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wherein the first reaction mixture comprises; (a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 900 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, wherein the second reaction mixture is blended with the polymeric portion of the first reaction mixture and comprises; (d) an amino terminated polysiloxane; and
(e) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 400 to about 2000;
and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2000 to about 10,000. - View Dependent Claims (12)
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13. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer comprising a combination of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol having an average molecular weight (MD) of about 600; and
a diamino terminated copolymer of polypropylene glycol and polyethylene glycol having an average molecular weight (MD) of about 900; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute polymeric portion of the first reaction mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000. - View Dependent Claims (14, 15)
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16. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 900 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture; wherein the polymeric portion of the mixture comprises about 50 mole percent polysiloxane, about 25 mole percent hydrophilic polymer having an average molecular weight (MD) of about 600, and about 25 mole percent hydrophilic polymer having an average molecular weight (MD) of about 900; and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2000 to about 10,000. - View Dependent Claims (17, 18, 19)
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20. An implantable biosensor for measuring an analyte in biological tissue, the biosensor having a coating adhered thereto, the coating comprising a biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 900 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000. - View Dependent Claims (21, 22, 23, 24)
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25. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer comprising a poly(propylene glycol)-block-poly(ethylene glycol) bis(2-aminopropyl ether); and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000. - View Dependent Claims (26, 27, 28)
(d) an amino terminated polysiloxane; and
(e) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 400 to about 2000.
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27. An implantable biosensor for measuring an analyte in biological tissue, the biosensor having a coating adhered thereto, the coating comprising a biocompatible membrane of claim 25.
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28. A method of measuring an analyte in a tissue of a subject, the method comprising introducing an implantable biosensor of claim 27 into the tissue of the subject and detecting the signal generated by the transducer, wherein the amount of signal corresponds to the amount of analyte.
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29. A biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture and a second reaction mixture, the first reaction mixture comprising:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 400 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, wherein the second reaction mixture is blended with the polymeric portion of the first reaction mixture and comprises; (d) an amino terminated polysiloxane; and
(e) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an avenge molecular weight (MD) of from about 400 to about 2000, wherein the polysiloxane content is about 50 mole percent of the polymeric portion of the mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000.
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30. An implantable biosensor for measuring an analyte in biological tissue, die biosensor having a coating adhered thereto, the coating comprising a biocompatible membrane comprising a hydrophilic polyurea composition comprising the product of a first reaction mixture comprising:
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(a) an amino terminated polysiloxane;
(b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight (MD) of from about 400 to about 2000; and
(c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′
-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;
wherein (a) and (b) constitute a polymeric portion of the first reaction mixture, wherein the polysiloxane content is about 50 mole percent of the polymeric portion of the mixture, and wherein the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from greater than 2,000 to about 10,000. - View Dependent Claims (31)
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Specification