Apparatus and methods for reducing lung volume

• US 6,645,205 B2
• Filed: 08/15/2001
• Issued: 11/11/2003
• Est. Priority Date: 08/15/2001
• Status: Expired due to Fees

• Current Assignee: Gateway Edi (Cognizant Technology Solutions Corp.)
• Original Assignee: Core Medical Incorporated
• Inventors: Ginn, Richard S.
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US09/931,681
• Publication Number:
  US 20030036755A1
• Time in Patent Office: 818 Days
• Field of Search: 606/41, 606/108, 606/213, 606/221, 607/99, 607/105, 607/113, 128/200.24, 128/207.15, 128/207.16, 128/887
• US Class Current: 606/41
• CPC Class Codes: A61B 17/04 for suturing wounds; Holders or packages for needles or suture materials suture materials A61L17/00
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1227 Spring clips
• CPC Class Codes: A61B 17/1285 for minimally invasive surgery
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2018/00541 Lung or bronchi

Abstract

Apparatus and methods are provided for reducing the volume of a lung using a clip including a plurality of tines. The clip is advanced along an interior of a bronchial passage to a predetermined location with the tines in a contracted condition. The tines are expanded outwardly to engage surrounding tissue, and then collapsed towards the contracted condition, thereby drawing the surrounding tissue inwardly to substantially close the bronchial passage from air flow therethrough. Optionally, electrical energy may be applied to the surrounding tissue after collapsing the tines to the contracted condition, thereby fusing the surrounding tissue together. The clip is then released within or removed from the passage.

Claims

1. An apparatus for isolating a region of a lung, comprising:

an elongate member comprising a proximal end, a distal end having a size for insertion into a bronchial passage, and a longitudinal axis extending between the proximal and distal ends;

a closure device carried by the distal end, the closure device comprising a plurality of tines that are movable between contracted and expanded conditions; and

a deflecting element carried by the distal end of the elongate member, at least one of the deflecting element and the closure device being movable relative to the other for engaging the closure device with the deflecting element to deflect the tines outwardly towards the expanded condition for engaging tissue surrounding the distal end;

the tines being collapsible towards the contracted condition for drawing the surrounding tissue inwardly to substantially close the bronchial passage.

2. The apparatus of claim 1, wherein the deflecting element comprises one or more ramped surfaces extending transversely outward from the distal end of the elongate member.

3. The apparatus of claim 2, wherein the closure device is slidably disposed on the distal end of the elongate member proximate the one or more ramped surfaces, and wherein the apparatus further comprises a pusher member proximate the closure device, the pusher member being movable relative to the elongate member for driving the tines onto the one or more ramped surfaces for deflecting the tines outwardly towards the expanded condition.

4. The apparatus of claim 3, wherein the closure device comprises an expandable collar from which the tines extend, and wherein the pusher member is movable relative to the elongate member for advancing the closure device over the one or more ramped surfaces, the collar expanding as it advanced over the one or more ramped surfaces.

5. The apparatus of claim 4, wherein the collar is biased to collapse radially inward upon being advanced over the one or more ramped surfaces, and wherein the tines are biased towards the contracted condition upon being advanced over the one or more ramped surfaces.

6. The apparatus of claim 1, further comprising a source of electrical energy coupled the closure device for delivering electrical energy to surrounding tissue via the tines.

7. The apparatus of claim 6, wherein the source of electrical energy comprises a radio frequency (RF) generator.

8. The apparatus of claim 7, wherein the plurality of tines comprise first and second tines, the first and second tines being electrically coupled to opposite terminals of the RF generator.

9. The apparatus of claim 7, wherein the closure device is coupled to a first terminal of the RF generator, the apparatus further comprising an electrode attachable to an exterior surface of a patient, the electrode being coupled to a second terminal of the RF generator.

10. The apparatus of claim 6, wherein at least a portion of the closure device is coupled to a first terminal of the source of electrical energy, and wherein another portion of the apparatus is coupled to a second opposite terminal of the source of electrical energy.

11. The apparatus of claim 1, wherein the elongate member comprises a tubular member including a lumen extending between the proximal and distal ends, the closure device being slidably deployable from within a distal portion of the lumen.

12. The apparatus of claim 11, further comprising a pusher member slidable within the lumen for deploying the closure device from the distal portion of the lumen.

13. The apparatus of claim 1, further comprising a bronchoscope associated with the elongate member for viewing beyond the distal end of the elongate member.

14. The apparatus of claim 13, wherein the bronchoscope is inserted through a lumen in the elongate member.

15. The apparatus of claim 1, wherein the elongate member comprises a lumen extending between the proximal and distal ends, the apparatus further comprising a source of fluid connected to the proximal end of the elongate member for delivering fluid to a location beyond the distal end of the elongate member.

16. The apparatus of claim 1, wherein the closure device comprises an opening and the deflecting element comprises an anvil received through the opening, the anvil and the closure device being keyed such that, when the anvil is in a first angular position relative to the closure device, axial movement of the anvil causes the tines of the closure device to be deflected towards the expanded condition, and, in a second angular position, the anvil is removable from the closure device through the opening.

17. The apparatus of claim 1, wherein the tines of the closure device are biased towards the contracted condition, but are deflectable towards the expanded condition.

18. The apparatus of claim 17, wherein the closure device comprises a generally annular shaped body from which the plurality of tines extend.

19. The apparatus of claim 17, wherein the plurality of tines extend towards one another in the contracted condition.

20. The apparatus of claim 17, wherein the plurality of tines extend generally parallel to the longitudinal axis of the elongate member in the contracted condition.

21. A method for reducing volume of a lung using a closure device comprising a plurality of tines movable between contracted and expanded conditions, the method comprising:

advancing the closure device with the tines in the contracted condition along a bronchial passage to a predetermined location;

expanding the tines outwardly towards the expanded condition to engage tissue surrounding the predetermined location; and

collapsing the tines towards the contracted condition, thereby drawing the surrounding tissue inwardly to substantially close the bronchial passage from air flow through the predetermined location.

22. The method of claim 21, wherein the closure device is carried by a distal end of an elongate member.

23. The method of claim 22, wherein the method further comprises releasing the closure device from the distal end after the tines engage and close the bronchial passage.

24. The method of claim 21, further comprising applying energy to the surrounding tissue after collapsing the tines to the contracted condition, thereby at least partially fusing the surrounding tissue together.

25. The method of claim 24, further comprising withdrawing the closure device from the predetermined location after the step of applying energy.

26. The method of claim 21, wherein the step of expanding the tines comprises engaging the closure device with a deflecting element, thereby causing the tines to deflect outward towards the expanded condition.

27. The method of claim 26, wherein the tines are biased towards the contracted condition, and wherein the step of collapsing the tines comprises advancing the closure device beyond the deflecting element, whereupon the tines automatically collapse towards the contracted condition.

28. The method of claim 21, further comprising delivering a substance to a location distal to the predetermined location before collapsing the tines.

29. The method of claim 28, wherein the substance comprises at least one of oxygen, helium, a corrosive agent, and a bonding agent.

30. The method of claim 28, wherein the substance comprises an electrically conductive fluid, and wherein the method further comprises delivering electrical energy via the fluid into the location distal to the predetermined location.

31. The method of claim 21, wherein the bronchial passage communicates with a region of a lung being isolated, the method further comprising hyper-inflating the region being isolated before collapsing the tines, wherein the region collapses upon itself after the tines are collapsed.

32. The method of claim 21, further comprising evacuating fluid from a location distal to the predetermined location before collapsing the tines.

33. The method of claim 21, further comprising applying an adhesive to the surrounding tissue after collapsing the tines to bond the tissue together.