Leukocyte depletion filter media, filter produced therefrom, method of making same and method of using same

• US 6,645,388 B2
• Filed: 12/19/2000
• Issued: 11/11/2003
• Est. Priority Date: 12/22/1999
• Status: Expired due to Fees

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Corporation
• Inventors: Sheikh-Ali, Bashir Musse
• Primary Examiner(s): Drodge, Joseph
• Assistant Examiner(s): MENON, KRISHNAN S
• Application Number:
  US09/746,202
• Publication Number:
  US 20010042724A1
• Time in Patent Office: 1,057 Days
• Field of Search: 210/767, 210/650-654, 210/500.37, 210/295, 210/500.29, 210/645, 210/503, 210/504, 210/506, 204/627, 428/43, 428/44
• US Class Current: 210/767
• CPC Class Codes: A61M 1/3633 Blood component filters, e.g. leukocyte filters
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes
• CPC Class Codes: B01D 39/202 sintered or bonded by inorganic agents

Abstract

A leukocyte depletion filter media includes nonwoven material or microfiber glass which has been coated with a polysaccharide originally containing functionalized side chains capable of crosslinking with each other and the filter media. The leukocyte depletion filter media preferably includes a polysaccharide having a charge density of up to 5 meq/g.

Claims

1. A method for manufacturing a leukocyte depletion filter media comprises the steps of:

a) preparing a filter media of a nonwoven material;

b) making the filter media wettable if it is non inherently wettable;

c) coating the media with a cationic polysaccharide having functionalized side groups capable of crosslinking; and

d) heating the filter media so as to cause the functionalized side groups in the coating to crosslink intramolecularly without the use of a crosslinking agent.

2. The method for manufacturing a leukocyte depletion filter of claim 1 wherein said coating step said polysaccharide includes a charge density of between about 0.2 meq/g to about 5 meq/g.

3. The method for manufacturing a leukocyte depletion filter of claim 2 wherein said coating step said polysaccharide includes a charge density of between 0.5 meq/g and 4.0 meq/g.

4. The method for manufacturing a leukocyte depletion filter media of claim 1 wherein step “

a)”

the filter media is prepared from a meltblown nonwoven material.

5. The method for manufacturing a leukocyte depletion filter media of claim 1 wherein step “

a)”

the filter media is prepared from multiple layers of nonwoven material.

6. The method for manufacturing a leukocyte depletion filter media of claim 1 wherein step “

a)”

the filter media is prepared from at least one prefilter layer and at least one filter layer.

7. The method for manufacturing a leukocyte depletion filter media of claim 1 wherein step “

b)”

the filter media is made wettable by exposing it to milk protein.

8. A method for manufacturing a leukocyte depletion filter media comprises the steps of:

a) preparing a filter media of a microfiber glass;

b) coating the media with a cationic polysaccharide having functionalized side groups capable of crosslinking; and

c) heating the filter media so as to cause the functionalized side groups in the coating to crosslink intramolecularly without the use of a crosslinking agent.

9. The method for manufacturing a leukocyte depletion filter of claim 8 wherein said coating step said polysaccharide includes a charge density of between about 0.2 and 5 meq/g.

10. The method for manufacturing a leukocyte depletion filter media of claim 8 wherein step a) the filter media is prepared from multiple layers of microfiber glass.

11. The method for manufacturing a leukocyte depletion filter media of claim 8 wherein step a) the filter media is prepared from at least one prefilter layer and at least one filter layer.

12. A method for manufacturing a leukocyte depletion filter media comprises the steps of a) preparing a wettable filter media of a nonwoven material, b) coating the media with a cationic polysaccharide having functionalized side groups capable of crosslinking, and c) heating the filter media so as to cause the functionalized side groups in the coating to crosslink intramolecularly without the use of a crosslinking agent.

13. The method for manufacturing a leukocyte depletion filter of claim 12 wherein said coating step said polysaccharide includes a charge density of between about 0.2 meq/g to about 5 meq/g.

14. The method for manufacturing a leukocyte depletion filter of claim 13 wherein said coating step said polysaccharide includes a charge density of between about 0.5 meq/g and 4.0 meq/g.

15. The method for manufacturing a leukocyte depletion filter media of claim 12 wherein step “

a)”

the filter media is prepared from a meltblown nonwoven material.

16. The method of manufacturing a leukocyte depletion filter media of claim 15 wherein step “

a)”

the filter media is prepared from nylon 6.

17. The method for manufacturing a leukocyte depletion filter media of claim 12 wherein step “

a)”

the filter media is prepared from multiple layers of nonwoven material.

18. The method for manufacturing a leukocyte depletion filter media of claim 17 wherein step “

a)”

the filter media is prepared from at least one prefilter layer and at least one filter layer.

19. A method of filtering leukocytes form whole blood includes the steps of:

a) obtaining a unit of whole blood;

b) passing the whole blood through a leukocyte depletion filter media including a filter media that has been coated with a cationic polysaccharide originally having functionalized side groups capable of crosslinking intramolecularly without the use of a crosslinking agent.

20. The method of filtering leukocytes from whole blood of claim 19 wherein said filter media has been coated with a polysaccharide originally having functionalized side groups capable of crosslinking and including a charge density of up to 5 meq/g.

21. A method of filtering leukocytes form whole blood includes the steps of:

a) obtaining a unit of whole blood;

b) separating the desirable blood component from the whole blood; and

c) passing the desirable blood component through a leukocyte depletion filter media including a filter media that has been coated with a cationic polysaccharide originally having functionalized side groups capable of crosslinking intramolecularly without the use of a crosslinking agent.

22. The method of filtering leukocytes from a blood component of claim 21 wherein said filter media has been coated with a polysaccharide having functionalized side groups capable of crosslinking and including a charge density of up to 5 meq/g.

23. A leukocyte depletion filter comprising:

a) a fluid intake;

b) a fluid exit; and

c) a leukocyte depletion filter media including a nonwoven material which has been coated with a cationic polysaccharide originally containing functionalized side chains capable of crosslinking intramolecularly without the use of a crosslinking agent, said filter situated between said fluid intake and said fluid exit.

24. The leukocyte depletion filter of claim 23 wherein said polysaccharide includes a charge density of up to 5 meq/g.

25. The leukocyte depletion filter of claim 23 wherein said filter media includes multiple nonwoven layers.

26. The leukocyte depletion filter of claim 23 wherein said filter media filters leukocytes to a level of approximately ten leukocytes per microliter as measured by the PI Test Method.

27. The leukocyte depletion filter of claim 23 wherein said filter media filters leukocytes to a level of between approximately four to ten leukocytes per microliter as measured by the PI Test Method.

28. A leukocyte depletion filter comprising:

a) a fluid intake;

b) a fluid exit; and

c) a leukocyte depletion filter media including a microfiber glass material which has been coated with a cationic polysaccharide originally containing functionalized side chains capable of crosslinking intramolecularly without the use of a crosslinking agent, said filter situated between said fluid intake and said fluid exit.

29. The leukocyte depletion filter of claim 28 wherein said filter media includes multiple microfiber glass layers.

30. The leukocyte depletion filter of claim 28 wherein said filter media filters leukocytes to a level of approximately ten leukocytes per microliter as measured by the PI Test Method.

31. The leukocyte depletion filter of claim 28 wherein said filter media filters leukocytes to a level of between approximately four to ten leukocytes per microliter as measured by the PI Test Method.

32. A leukocyte depletion filter media comprising:

nonwoven material which has been coated with a cationic polysaccharide originally containing functionalized side chains capable of crosslinking intramolecularly without the use of a crosslinking agent.

33. The leukocyte depletion filter media of claim 32 wherein said nonwoven material includes multiple nonwoven layers.

34. The leukocyte depletion filter media of claim 32 wherein said nonwoven material filters leukocytes to a level of approximately ten leukocytes per microliter as measured by the PI Test Method.

35. The leukocyte depletion filter media of claim 32 wherein said nonwoven material filters leukocytes to a level of between approximately four to ten leukocytes per microliter as measured by the PI Test Method.

36. A leukocyte depletion filter media comprising:

a microfiber glass material which has been coated with a cationic polysaccharide originally containing functionalized side chains capable of crosslinking intramolecularly without the use of a crosslinking agent.

37. The leukocyte depletion filter of claim 36 wherein said microfiber glass material includes multiple layers.

38. The leukocyte depletion filter media of claim 36 wherein said microfiber glass material filters leukocytes to a level of approximately ten leukocytes per microliter as measured by the PI Test Method.

39. The leukocyte depletion filter media of claim 36 wherein said microfiber glass material filters leukocytes to a level of between approximately four to ten leukocytes per microliter as measured by the PI Test Method.