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Storage stable thyroxine active drug formulations and methods for their production

  • US 6,645,526 B2
  • Filed: 11/13/2001
  • Issued: 11/11/2003
  • Est. Priority Date: 11/13/2001
  • Status: Expired due to Term
First Claim
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1. A storage stable oral pharmaceutical composition in unit dosage form which comprises:

  • (a) a therapeutically effective amount of levothyroxine sodium;

    (b) about 58% by weight mannitol;

    (c) about 14% by weight sucrose;

    (d) about 25% by weight microcrystalline cellulose;

    (e) about 1.5% by weight polyvinylpyrrolidone;

    (f) about 1.4% by weight magnesium stearate;

    (g) about 0.3% by weight colloidal silicon dioxide; and

    (h) about 0.1% by weight sodium lauryl sulfate.

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