Treatment of gastro-intestinal disorders
First Claim
1. A method for the treatment of a chronic gastro-intestinal disorder selected from the group consisting of spastic colon, mucous colitis, collagenous colitis, inflammatory bowel disease, microscopic colitis, idiopathic or simple constipation, diverticular disease, chronic idiopathic pseudo obstructive syndrome and chronic enteric infections, in an adult human host, where the causative agent is unknown, which method comprises substantially completely removing the host'"'"'s existing enteric microflora by a method comprising using a lavage, and the substitution of an effective amount of fresh or dried or reconstituted feces from a disease-screened human donor or the administration of an effective amount of a pharmaceutically acceptable composition comprising microorganism selected from the group consisting of Batcteroides and E. coli in liquid culture or dried viable form.
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Accused Products
Abstract
A method of treating chronic disorders associated with the presence of abnormal microflora or an abnormal distribution of microflora in the gastrointestinal tract involves removing the host'"'"'s existing enteric microflora and substitution of feces from a disease screener donor or composition comprising microorganism selected from the group consisting of Bacteroides and E. coli.
227 Citations
30 Claims
- 1. A method for the treatment of a chronic gastro-intestinal disorder selected from the group consisting of spastic colon, mucous colitis, collagenous colitis, inflammatory bowel disease, microscopic colitis, idiopathic or simple constipation, diverticular disease, chronic idiopathic pseudo obstructive syndrome and chronic enteric infections, in an adult human host, where the causative agent is unknown, which method comprises substantially completely removing the host'"'"'s existing enteric microflora by a method comprising using a lavage, and the substitution of an effective amount of fresh or dried or reconstituted feces from a disease-screened human donor or the administration of an effective amount of a pharmaceutically acceptable composition comprising microorganism selected from the group consisting of Batcteroides and E. coli in liquid culture or dried viable form.
- 9. A method for the treatment of a chronic gastro-intestinal disorder selected from the group consisting of ulcerative colitis, Crohn'"'"'s disease, and irritable bowel syndrome, in an adult human host, where the causative agent is unknown, which method comprises substantially completely removing the host'"'"'s existing enteric microflora by a method comprising using a lavage, and the substitution of an effective amount of fresh or dried or reconstituted feces from a disease-screened human donor or the administration of an effective amount of a pharmaceutically acceptable composition comprising microorganism selected from the group consisting of Bacteroides and E. coli in liquid culture or dried viable form.
- 19. A method for treating a chronic disorder associated with the presence of abnormal enteric microflora in an individual comprising substantially completely removing the existing enteric microflora of the individual by a lavage and the administration in place thereof of an effective amount of fresh or dried or reconstituted feces from a disease screened donor or of a pharmaceutically acceptable composition comprising microorganism selected from the group consisting of Bacteroides and E. coli in liquid culture or dried viable form.
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28. A method for treating a chronic gastro-intestinal disorder in an individual comprising substantially completely removing the existing enteric microflora of the individual by a lavage and the administration in place thereof of an effective amount of fresh or dried or reconstituted feces from a disease screened donor or of a pharmaceutically acceptable composition comprising microorganism selected from the group consisting of Bacteroides and E. coli in liquid culture or dried viable form.
Specification