Method of making coated chewing gum products containing various antacids

• US 6,645,535 B2
• Filed: 12/22/2000
• Issued: 11/11/2003
• Est. Priority Date: 09/02/1999
• Status: Expired due to Fees

• Current Assignee: WM Wrigley Jr Company (Mars Incorporated)
• Original Assignee: WM Wrigley Jr Company (Mars Incorporated)
• Inventors: Barkalow, David G., Greenberg, Michael J., Marske, Scott W., Zyck, Daniel J., Schnell, Philip G., Mazzone, Philip
• Primary Examiner(s): Corbin, Arthur L.
• Application Number:
  US09/747,323
• Publication Number:
  US 20010021403A1
• Time in Patent Office: 1,054 Days
• Field of Search: 426/3, 426/5, 424/48, 424/440
• US Class Current: 426/5
• CPC Class Codes: A23G 4/00 Chewing gum
• CPC Class Codes: A23G 4/025 for coating or surface-finishing
• CPC Class Codes: A23G 4/06 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 4/064 containing inorganic compounds
• CPC Class Codes: A23G 4/068 containing plants or parts thereof, e.g. fruits, seeds, extracts containing gums A23G4/10
• CPC Class Codes: A23G 4/10 characterised by the carbohydrates used, e.g. polysaccharides containing dairy products A23G4/16
• CPC Class Codes: A23G 4/126 containing vitamins, antibiotics
• CPC Class Codes: A23G 4/20 Composite products, e.g. centre-filled , multi-layer, laminated
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/341 not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/426 1,3-Thiazoles
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/12 Magnesium silicate
• CPC Class Codes: A61K 33/245 Bismuth; Compounds thereof
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 9/0058 Chewing gums non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00
• CPC Class Codes: A61K 9/2086 Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat active cores with a complete drug-free outer coat A61K9/28
• CPC Class Codes: A61K 9/209 containing drug in at least two layers or in the core and in at least one outer layer

Abstract

A method of making antacid coated chewing gum products comprises the steps of providing chewing gum cores; providing a coating syrup comprising a bulk sweetener and a neutralizing antacid suspended in the coating syrup, the coating syrup containing from about 25% to about 50% by weight of the solids in the syrup of a neutralizing antacid, selected from the group consisting of aluminum salts, bismuth salts, magnesium salts, sodium bicarbonate, potassium bicarbonate, potassium citrate, sodium potassium tartrate, tricalcium phosphate and mixtures thereof, and applying the coating syrup to the cores and drying the syrup to produce a coating on the cores. Methods of use of the product to provide relief in the gastrointestinal tract are also included.

Claims

1. A method of making antacid coated chewing gum products comprising the steps of:

a) providing chewing gum cores;

b) providing a coating syrup comprising;

i) a bulk sweetener and

ii) a neutralizing antacid suspended in the coating syrup;

the coating syrup containing from about 25% to about 50% by weight of the solids in the syrup of the neutralizing antacid, the neutralizing antacid being selected from the group consisting of aluminum salts, bismuth salts, magnesium salts, sodium bicarbonate, potassium bicarbonate, potassium citrate, sodium potassium tartrate, tricalcium phosphate and mixtures thereof; and

c) applying the coating syrup to the cores and drying the syrup to produce a coating on the cores.

2. The method of claim 1 wherein the bulk sweetener is a polyol.

3. The method of claim 1 wherein the bulk sweetener is a sugar.

4. The method of claim 3 wherein the polyol is selected from the group consisting of sorbitol, xylitol, erythritol, maltitol, lactitol, hydrogenated isomaltulose and combinations thereof.

5. The method of claim 1 wherein the neutralizing antacid is selected from the group consisting of carbonate and hydroxide salts of magnesium, aluminum and bismuth.

6. The method of claim 1 wherein the antacid has a median particle size of between about 3 microns and about 75 microns.

7. The method of claim 1 wherein the antacid has a median particle size of between about 3 microns and about 15 microns.

8. The method of claim 1 wherein the coating syrup further comprises a binding agent.

9. The method of claim 8 wherein the binding agent is selected from the group consisting of gum arabic, gum talha, guar gum, karaya gum, locust bean gum, alginate gums, xanthan gum, arabinogalactan, cellulose derivatives, vegetable gums, gelatin and mixtures thereof.

10. The method of claim 8 wherein the binding agent comprises at least about 2% of the coating syrup.

11. The method of claim 1 wherein the antacid comprises between about 30% and about 40% of the total solids in the coating syrup.

12. The method of claim 1 wherein the coated products contain 250 to 800 milligrams of antacid per piece.

13. The method of claim 1 wherein the antacid comprises between about 30% and about 40% of the coating.

14. The method of claim 1 wherein the coating further comprises a high-intensity sweetener.

15. The method of claim 14 wherein the high-intensity sweetener is selected from the group consisting of sucralose, aspartame, N-substituted APM derivatives, salts of acesulfame, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizin, dihydrochalcones, thaumatin, monellin and mixtures thereof.

16. The method of claim 14 wherein the high-intensity sweetener is applied as part of a different coating syrup from the coating syrup containing the antacid.

17. The method of claim 14 wherein the high-intensity sweetener comprises acesulfame K.

18. The method of claim 1 wherein the bulk sweetener comprises maltitol.

19. The method of claim 1 wherein the coating is sugarless.

20. The method of claim 1 wherein a powdered bulk sweetener is applied to the cores after application of the coating syrup.

21. The method of claim 1 wherein the coating further comprises an acid blocker.

22. The method of claim 21 wherein the acid blocker comprises a histamine H₂-receptor antagonist.

23. The method of claim 22 wherein the histamine H₂-receptor antagonist is selected from the group consisting of cimetidine, ranitidine and its active salt, famotidine, nizatidine and mixtures thereof.

24. The method of claim 22 wherein the histamine H₂-receptor antagonist comprises famotidine.

25. The method of claim 1 wherein the antacid is an aluminum salt selected from the group consisting of aluminum sodium carbonate hexitol complex;

carbonic acid-aluminum magnesium complex;

aluminum hydroxide;

aluminum magnesium silicate;

aluminum phosphate;

aluminum hydroxide-aluminum carbonate gel;

basic aluminum sucrose sulfate complex;

dihydroxyaluminum aminoacetate;

dihydroxyaluminum sodium carbonate;

aluminum magnesium hydroxide monohydrate and mixtures thereof.

26. The method of claim 1 wherein the antacid is a bismuth salt selected from the group consisting of bismuth aluminate, bismuth phosphate, bismuth carbonate, bismuth subcarbonate, bismuth subgallate, bismuth subnitrate and mixtures thereof.

27. The method of claim 1 wherein the antacid is a magnesium salt selected from the group consisting of magnesium carbonate;

magnesium hydroxide;

magnesium oxide;

magnesium peroxide;

magnesium phosphate, tribasic;

magnesium silicates;

magnesium aluminosilicates and mixtures thereof.

28. A method of making antacid coated chewing gum products comprising the steps of:

a) providing chewing gum cores;

b) providing a coating syrup comprising;

i) a bulk sweetener and

ii) a neutralizing antacid having a median particle size of at least about 3 microns and being suspended in the coating syrup, the coating syrup containing from about 25% to about 50% by weight of the solids in the syrup of the neutralizing antacid, the neutralizing antacid being selected from the group consisting of aluminum salts, bismuth salts, magnesium salts, sodium bicarbonate, potassium bicarbonate, potassium citrate, sodium potassium tartrate, tricalcium phosphate and mixtures thereof;

c) providing a dry charge material comprising a bulk sweetener; and

d) applying the coating syrup and dry charge material to the chewing gum cores to produce a coating on the cores.

29. The method of claim 28 wherein the coating comprises about 30% to about 75% maltitol.

30. The method of claim 28 wherein multiple coats of coating syrup and dry charge material are applied to build up the coating.

31. The method of claim 28 wherein the dry charge material and coating syrup both include maltitol as the bulk sweetener.

32. A method of delivering an antacid to an individual that provides relief in the gastrointestinal tract comprising the steps of:

a) providing chewing gum cores;

b) providing a coating syrup comprising;

i) a bulk sweetener and

ii) a neutralizing antacid suspended in the coating syrup, the coating syrup containing from about 25% to about 50% by weight of the solids in the syrup of the neutralizing antacid, the neutralizing antacid being selected from the group consisting of aluminum salts, bismuth salts, magnesium salts, sodium bicarbonate, potassium bicarbonate, potassium citrate, sodium potassium tartrate, tricalcium phosphate and mixtures thereof;

c) applying the coating syrup to the cores and drying the syrup to produce a coating on the cores; and

d) chewing the antacid coated chewing gum product in the mouth and swallowing the coating, the coating dispersing and dissolving to provide an antacid in the gastrointestinal tract.