Medical screening

• US 6,652,456 B2
• Filed: 12/06/2000
• Issued: 11/25/2003
• Est. Priority Date: 12/06/2000
• Status: Expired due to Term

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Gelfand, Jeffrey A., Brauns, Timothy A.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): ASTORINO, MICHAEL C
• Application Number:
  US09/731,101
• Publication Number:
  US 20020068856A1
• Time in Patent Office: 1,084 Days
• Field of Search: 600/300-301, 600/407, 705/1-4, 382/133, 382/128, 345/665, 345/671, 356/372, 364/413.02, 128/903-904, 128/920-925, 435/4, 435/21, 702/19, 709/200, 709/100, 359/368, 707/104.1
• US Class Current: 600/300
• CPC Class Codes: G01N 15/1433 using image recognition
• CPC Class Codes: G01N 2015/1488 Methods for deciding
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

Mass medical, e.g., cervical cancer, screening is provided to areas of the world where a lack of sufficient laboratory infrastructure and technical skills presently compromises the effectiveness of screening or even makes mass screening impossible. These methods are cost-effective and provide excellent sensitivity and specificity in cervical cancer screening.

Claims

1. A method comprising

in a first geographic location, automatically screening diagnostic data associated with patients to screen out data for which a medical interpretation is negative, and automatically producing digital images associated with data as to which there are possibly positive medical interpretations;

the first geographic location being one in which the automatic screening is permitted to be done as part of a medical diagnosis;

transmitting the digital images electronically to a second geographic location;

at the second geographic location, presenting the digital images to an experienced person to provide evaluations of the possibly positive medical interpretations; and

returning the evaluations electronically to the first geographic location;

the first geographic location being one in which a ratio of experienced people capable of providing the evaluations to a population needing screening is lower than in the second geographic location.

3. The method of claim 1 or 2 wherein the first geographic location comprises a developing country.

4. The method of claim 1 or 2 wherein the second geographic location comprises an industrialized country.

6. The method of claim 1 or 2 wherein the transmitting and returning steps are performed via the Internet.

7. The method of claim 1 or 2 wherein the transmitting and returning steps are performed via email.

2. A method comprising:

in a first geographic location, automatically screening Pap smear slides to screen out slides for which a medical interpretation is negative and automatically processing the remaining slides to produce digital images of cellular features as to which there are possibly positive medical interpretations;

the first geographic location being one in which the automatic screening is permitted to be done as part of a medical diagnosis;

transmitting the digital images electronically to a second geographic location;

at the second geographic location, presenting the digital images to an experienced person to provide evaluations of the possibly positive medical interpretations; and

returning the evaluations electronically to the first geographic location;

the first geographic location being one in which a ratio of experienced people capable of providing the evaluations to a population needing screening is lower than in the second geographic location.

5. The method of claim 2 wherein the experienced person comprises a cytotechnologist or cytopathologist.

8. The method of claim 2 further comprising preparing the Pap smears using a liquid-based thin-film sample preparation process.

9. The method of claim 8 wherein the preparing step is performed using an automated system.

10. The method of claim 2 wherein the remaining slides represent less than about 50% of the Pap smear slides.

11. A method comprising

receiving, at a second geographic location, an electronic transmission of a file from a first location, the file including information identifying a patient and images of cells sampled from the cervix of the patient, the file having been automatically screened, prior to transmission, so that the file is only transmitted if it contains cells as to which there are possibly positive medical interpretations,

the first geographic location being one in which the automatic screening is permitted to be done as part of a medical diagnosis,

providing an evaluation of the images, the generating step being performed by an experienced person, and the first geographic location being one in which a ratio of experienced people capable of providing the evaluation to a population needing screening is lower than in the second geographic location, and

transmitting the evaluation electronically to the first geographic location.

12. The method of claim 11 wherein the experienced person comprises a cytotechnologist or cytopathologist.

13. The method of claim 11 wherein the transmitting step is performed via the Internet.

14. The method of claim 11 wherein the transmitting step is performed via email.

15. A method of providing a medical interpretation of each of a number of Pap smears, by utilizing the facilities at a remote geographic location, comprising

in a first geographic location, automatically screening the Pap smear slides to screen out slides for which the medical interpretation is negative, and automatically processing the remaining slides to produce digital images of cellular features that are likely to be indicative of abnormality,

the first geographic location being one in which the automatic screening is permitted to be done as part of a medical diagnosis,

transmitting the digital images electronically to the remote geographic location for evaluation, and

receiving the evaluation electronically from the remote geographic location,

the first geographic location being one in which a ratio of experienced people capable of generating the evaluation to a population needing screening is lower than in the remote geographic location.

16. The method of claim 15 wherein each raw image data file includes images of cells, and the method further includes, prior to electronic transmission of the remaining files, processing the remaining files to select for transmission images of cells which are most likely to result in a positive medical interpretation.

17. The method of claim 15 wherein the experienced person comprises a cytotechnologist or cytopathologist.

18. The method of claim 15 wherein the transmitting and receiving steps are performed via the Internet.

19. The method of claim 15 wherein the transmitting and receiving steps are performed via email.

20. The method of claim 15 further comprising preparing the Pap smears using a liquid-based thin-film sample preparation process.

21. The method of claim 20 wherein the preparing step is performed using an automated system.

22. The method of claim 15 wherein the remaining slides represent less than 50% of the Pap smear slides.