Pharmaceutical preparations and methods for their regional administration
First Claim
1. A drug formulation, comprising drug particles suitable for local or regional administration of an effective amount of the drug to provide relief from symptoms in a region in patients in need thereof, wherein the effective amount is less than the effective amount when the drug is administered systemically andwherein the drug is selected from the group consisting of anticancer drugs, cytotherapeutic drugs, anti-proliferative drugs, and antiviral drugs.
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Accused Products
Abstract
Formulations have been developed for regional delivery of drugs, for example, into a cavity such as the pelvic region, peritoneal region, or directly on organs of interest. Regional delivery increases comfort and bioavailability of the drug, resulting in rapid and relatively high blood levels in the regions to be treated in the substantial absence of side effects due to the high levels required for efficacy following systemic delivery. In the preferred embodiment, these formulations consist of drug micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or polymeric carrier. The excipient or polymer may be used to manipulate release rates and to increase adhesion to the affected region. The drug formulation can be applied as a dried powder, a liquid suspension or dispersion, or as a topical ointment, creme, lotion, foam or suppository.
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Citations
20 Claims
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1. A drug formulation, comprising drug particles suitable for local or regional administration of an effective amount of the drug to provide relief from symptoms in a region in patients in need thereof, wherein the effective amount is less than the effective amount when the drug is administered systemically and
wherein the drug is selected from the group consisting of anticancer drugs, cytotherapeutic drugs, anti-proliferative drugs, and antiviral drugs.
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5. A method of treating a patient comprising the step of administering to the patient an effective amount of a drug formulation, comprising drug particles suitable for local or regional administration of an effective amount of the drug to provide relief from symptoms in a region in the patient in need thereof, wherein the effective amount is less than the effective amount when the drug is administered systemically and
wherein the drug is selected from the group consisting of anticancer drugs, cytotherapeutic drugs, anti-proliferative drugs, and antiviral drugs.
Specification