Cross-regulin composition of tumeric-derived tetrahydrocurcuminoids for skin lightening and protection against UVB rays

• US 6,653,327 B2
• Filed: 10/09/2001
• Issued: 11/25/2003
• Est. Priority Date: 04/09/1999
• Status: Expired due to Term

• Current Assignee: Sami Labs Limited
• Original Assignee: Sabinsa Corporation (Sami-Sabinsa Group Limited)
• Inventors: Badmaev, Vladimir, Majeed, Muhammed
• Primary Examiner(s): Dodson, Shelle A.
• Application Number:
  US09/972,150
• Publication Number:
  US 20020197216A1
• Time in Patent Office: 777 Days
• Field of Search: 424/59, 424/60, 424/400, 424/401, 424/195.1, 514/321, 514/492, 514/499, 514/505, 514/720, 514/733
• US Class Current: 514/321
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 41/0057 Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin

Abstract

The present invention is directed to a mixture of tetrahydrocurcuminoids which can be used for regulating random, intracellular protein cross-linking an optimizing cell electric potential in a patient.

Claims

1. A method for regulating random, intracellular protein cross-linking and optimizing cell electric potential in a patient in need of such regulation, comprising administering an effective amount of a mixture of tetrahydrocurcuminoids (THC) to the a patient in need of such regulation.

2. The method according to claim 1, wherein said random, intracellular cross-linking is a post-translational modification of a protein.

3. The method according to claim 1, wherein said random, intracellular cross-linking is modified by the THC to provide safe and effective mucosa, serosa or skin protection against physical, chemical and/or biologic elements.

4. The method according to claim 1, wherein said random, intracellular cross-linking is modified by the THC to provide safe and effective skin protection against UVA and/or and UVB.

5. The method according to claim 1, wherein said random, intracellular cross-linking is modified by the THC to effectively inhibit tyrosinase without causing side effects resulting from that inhibition.

6. The method according to claim 1, wherein said random, intracellular cross-linking is modified by the THC to regulate intracellular ras proteins.

7. The method according to claim 1, wherein said random, intracellular cross-linking is modified by the THC to inhibit protein cross-linking due to the presence of a malignancy.

8. The method according to claim 1, wherein said tetrahydrocurcuminoids comprise 70-80% tetrahydrocurcumin, 15-20% tetrahydrodemethoxycurcumin, and 2.5-6.5% tetrahydrobisdemethoxycurcumin.

10. The method according to claim 1, wherein said mixture is in a form suitable for topical administration.

11. The method according to claim 1, wherein said mixture is in a form suitable for oral application.

12. The method according to claim 1, wherein said mixture is in a form suitable for parenteral application.

9. A mixture comprising 70-80% tetrahydrocurcumin, 15-20% tetrahydrodemethoxycurcumin, and 2.5-6.5% tetrahydrobisdemethoxycurcumin, wherein said mixture is substantially colorless.

13. The mixture according to claim 9, wherein said mixture is in a form suitable for topical administration.

14. The mixture according to claim 9, wherein said mixture is in a form suitable for oral administration.

15. The mixture according to claim 9, wherein said mixture is in a form suitable for parenteral administration.