Modified oligonucleotides
First Claim
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1. An oligonucleotide comprising a plurality of nucleotides covalently linked together by internucleotide linkages, wherein at least one of said internucleotide linkages is selected from the group consisting of phosphodiester linkages and phosphorothioate linkages and at least one of said nucleotides is linked to an adjacent nucleotide by a 2′
- ,5′
-internucleotide linkage and bears a 3′
-substituent of the formula
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Abstract
Modified oligonucleotides containing at least one 2′,5′-internucleotide linkage are provided. The oligonucleotides of the invention may also bear additional substituents at the 2′- and 3′-positions.
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Citations
16 Claims
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1. An oligonucleotide comprising a plurality of nucleotides covalently linked together by internucleotide linkages, wherein at least one of said internucleotide linkages is selected from the group consisting of phosphodiester linkages and phosphorothioate linkages and at least one of said nucleotides is linked to an adjacent nucleotide by a 2′
- ,5′
-internucleotide linkage and bears a 3′
-substituent of the formula - View Dependent Claims (2, 3, 4, 5, 6, 8, 11, 12)
- ,5′
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7. An oligonucleotide comprising a plurality of nucleotides covalently linked together by internucleotide linkages, wherein at least one of said nucleotides is linked to an adjacent nucleotide by a 2′
- ,5′
-internucleotide linkage and bears a 3′
-substituent of the formula
- ,5′
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9. An oligonucleotide comprising a plurality of nucleotides covalently linked together by internucleotide linkages, wherein at least one of said nucleotides is linked to an adjacent nucleotide by a 2′
- ,5′
-internucleotide linkage and bears a 3′
-substituent of the formula
- ,5′
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10. An oligonucleotide comprising a plurality of nucleotides covalently linked together by internucleotide linkages, wherein at least one of said nucleotides is linked to an adjacent nucleotide by a 2′
- ,5′
-internucleotide linkage and bears a 3′
-substituent of the formula
- ,5′
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13. An oligonucleotide comprising a plurality of nucleotides covalently linked together by internucleotide linkages, wherein at least one of said nucleotides is linked to an adjacent nucleotide by a 2′
- ,5′
-internucleotide linkage and bears a 3′
-substituent having one of the formulas;
where; y1 is 0 or 1;
y2 is 0 to 10;
y3 is 1 to 10;
E is N(R41)(R42) or N═
C(R41)(R42); and
each R41 and each R42 is independently H, C1-C10 alkyl, a nitrogen protecting group, or R41 and R42 taken together form a nitrogen protecting group;
or R41 and R42 taken together with the N or C atom to which they are attached form a ring structure that can include at least one heteroatom selected from N and O.- View Dependent Claims (14, 15, 16)
- ,5′
Specification