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Nucleotide compounds including a rigid linker

  • US 6,653,462 B2
  • Filed: 02/26/2002
  • Issued: 11/25/2003
  • Est. Priority Date: 05/29/1998
  • Status: Expired due to Term
First Claim
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1. A nucleoside/tide compound comprising the structure:

  • embedded imagewherein;

    NUC is a nucleoside/tide having a nucleobase B;

    L is a rigid linkage having the structure;

    wherein each of n, o and p are integers ranging from 0 to 3, and the sum of n, o and p is at least 2; and

    each of W, X, Y and Z is independently selected from CH and N, including substituted forms thereof;

    S is a spacer selected from C1-C8 lower alkyl, lower alkylene oxide, amide, carbamate, and sulfonamide;

    wherein lower alkylene oxide is selected from the structures;

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