Ion sampling for APPI mass spectrometry
First Claim
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1. An atmospheric pressure ion source, comprising:
- a vaporizer with a center axis;
a photon source adjacent said vaporizer for creating ions from vapor molecules exiting the vaporizer;
a passageway adjacent said vaporizer and having a center axis, said center axis of said vaporizer and said center axis of said passageway defining an angle therebetween that is in the range of about 20 to 180 degrees; and
a means interposed between the vaporizer and the passageway for directing the ions into the passageway.
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Abstract
An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
103 Citations
26 Claims
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1. An atmospheric pressure ion source, comprising:
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a vaporizer with a center axis;
a photon source adjacent said vaporizer for creating ions from vapor molecules exiting the vaporizer;
a passageway adjacent said vaporizer and having a center axis, said center axis of said vaporizer and said center axis of said passageway defining an angle therebetween that is in the range of about 20 to 180 degrees; and
a means interposed between the vaporizer and the passageway for directing the ions into the passageway. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A mass spectrometer system comprising:
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an atmospheric pressure ion source comprising a vaporizer with a center axis;
a photon source adjacent said vaporizer for creating ions from vapor molecules exiting the vaporizer;
a passageway adjacent said vaporizer and having a center axis, said center axis of said vaporizer and said center axis of said passageway defining an angle therebetween that is in the range of about 20 to 180 degrees; and
a means interposed between the vaporizer and the passageway for directing the ions into the passageway; and
a mass analyzer coupled to the atmospheric pressure ion source such that ions traveling through the passageway are transported into the mass analyzer.
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19. A method for supplying ions to a mass spectrometer, comprising:
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directing a stream of vaporized molecules approximately along a molecular axis;
irradiating the stream of vaporized molecules with photons to produce the ions; and
moving the ions into a passageway having a center axis, wherein the molecular axis and the center axis of the passageway define an angle in the range of about 20 to 180 degrees. - View Dependent Claims (20, 21)
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22. A method for analyzing ions, comprising
directing a stream of vaporized molecules approximately along a molecular axis; -
irradiating the stream of vaporized molecules with photons to produce the ions; and
moving the ions into a passageway having a center axis, wherein the molecular axis and the center axis of the passageway define an angle in the range of about 20 to 180 degrees; and
measuring the mass to charge ratios of the ions. - View Dependent Claims (23, 24)
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25. A method for creating and transporting ions in an atmospheric pressure ion source, comprising:
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photoionizing a stream of vaporized molecules directed approximately along a molecular axis; and
moving ions so created along a central axis of a passageway, wherein said central axis and the molecular axis define an angle in the range of about 20 to 180 degrees. - View Dependent Claims (26)
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Specification