Method for improving non-invasive determination of the concentration of analytes in a biological sample
First Claim
1. A method for determining the concentration of analyte in a biological sample comprising the steps of:
- (a) providing an optical measuring instrument that comprises at least one thermally controllable optical measuring element that comes into contact with a surface of said biological sample;
(b) applying an inert, thermally conductive, optically transparent coupling agent to said at least one optical measuring element or to said surface of said biological sample or both so that said coupling agent will be disposed at the interface of said surface of said biological sample and said at least one optical measuring element, said coupling agent selected from the group consisting of silicone oil, mineral oil, polyethylene glycols, and oils from natural resources;
(c) measuring at least one optical property of said biological sample by means of said at least one optical measuring element; and
(d) correlating the at least one optical property of said biological sample with the concentration of said analyte in said biological sample.
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Abstract
A method for determining the concentration of an analyte in a biological sample comprising the steps of:
(1) providing an optical measuring instrument comprising a thermally controllable optical measuring element that comes into contact with the surface of the biological sample;
(2) applying a coupling agent to the optical measuring element or to the surface of the biological sample or to both so that the coupling agent will be disposed at the interface of the surface of the biological sample and the optical measuring element;
(3) measuring optical properties of the biological sample by means of the optical measuring instrument; and
(4) correlating the optical properties of the biological sample with the concentration of the analyte in the biological sample.
The coupling agent can be selected from the group consisting of silicone oil, mineral oil, polyethylene glycols, and oils from natural resources.
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Citations
12 Claims
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1. A method for determining the concentration of analyte in a biological sample comprising the steps of:
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(a) providing an optical measuring instrument that comprises at least one thermally controllable optical measuring element that comes into contact with a surface of said biological sample;
(b) applying an inert, thermally conductive, optically transparent coupling agent to said at least one optical measuring element or to said surface of said biological sample or both so that said coupling agent will be disposed at the interface of said surface of said biological sample and said at least one optical measuring element, said coupling agent selected from the group consisting of silicone oil, mineral oil, polyethylene glycols, and oils from natural resources;
(c) measuring at least one optical property of said biological sample by means of said at least one optical measuring element; and
(d) correlating the at least one optical property of said biological sample with the concentration of said analyte in said biological sample. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for measuring the concentration of an analyte in a tissue of a body part comprising the steps of:
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(a) providing an optical measuring instrument that comprises at least one thermally controllable optical measuring element that comes into contact with the surface of said tissue;
(b) applying an inert, thermally conductive, optically transparent coupling agent to said at least one optical measuring element or to the surface of said tissue or both so that said coupling agent will be disposed at the interface of said surface of said tissue and said at least one optical measuring element, said coupling agent selected from the group consisting of silicone oil, mineral oil, polyethylene glycols, and oils from natural resources;
(c) inducing a change in the concentration of said analyte in said tissue over a defined period of time;
(d) measuring the change in at least one optical property of said tissue by means of said at least one optical measuring element during said defined period of time;
(e) determining the change in the concentration of said analyte in said tissue by means of a reference method that involves taking a sample from said tissue for analysis during said defined period of time;
(f) correlating the change in said at least one optical property of said tissue with the change in the concentration of the analyte in said tissue to derive calibration data; and
(g) using said calibration data to determine the concentration of said analyte in said tissue. - View Dependent Claims (8, 9, 10, 11, 12)
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Specification