Implantable biomarker and method of use

• US 6,654,629 B2
• Filed: 04/11/2002
• Issued: 11/25/2003
• Est. Priority Date: 01/23/2002
• Status: Expired due to Fees

• Current Assignee: Valentino Montegrande
• Original Assignee: Valentino Montegrande
• Inventors: Montegrande, Valentino
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US10/120,721
• Publication Number:
  US 20030139669A1
• Time in Patent Office: 593 Days
• Field of Search: 600/407, 600/410-424, 600/426-427, 600/439, 600/458, 600/461, 604/100, 604/117, 604/20, 604/22, 606/1, 606/96, 606/98, 606/102, 606/104
• US Class Current: 600/424
• CPC Class Codes: A61B 17/1703 using imaging means, e.g. by X-rays
• CPC Class Codes: A61B 17/1725 for applying transverse screws or pins through intramedullary nails or pins
• CPC Class Codes: A61B 17/1757 for the spine
• CPC Class Codes: A61B 17/86 Pins or screws or threaded wires; nuts therefor A61B17/72 take precedence
• CPC Class Codes: A61B 2034/2072 Reference field transducer attached to an instrument or patient
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3983 Reference marker arrangements for use with image guided surgery
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/0875 for diagnosis of bone A61B5/4504 takes precedence
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers

Abstract

The present invention provides an implantable biomarker for finding a location inside a patient while performing minimally invasive or open surgical procedures. The implantable biomarker includes a dielectric base that includes two opposing sides from which extend a plurality of wave-guide rods. The implantable biomarker is preferably mounted upon a surgical instrument or surgical implant and used in conjunction with an image-guided system to enable a surgeon to quickly and easily find the location without requiring extensive x-rays or the use of expensive and cumbersome equipment.

Claims

1. An implantable biomarker for tracking a device in a mammalian body, the implantable biomarker comprising:

a dielectric base having a means for mounting the implantable biomarker on the device; and

a plurality of wave-guide rods, the plurality of wave-guide rods being disposed on a plane and extending from the dielectric base in a parallel orientation, the plurality of wave-guide rods being integral with the dielectric base.

2. The implantable biomarker of claim 1 wherein the dielectric base includes two opposing sides extending from the dielectric base, and each of the plurality of wave-guide rods extend from, in alternating order, one of the two opposing sides, such that each of the plurality of wave-guide rods overlaps those adjacent, between the two opposing sides.

3. An image guided system for tracking a device in a mammalian body, the image guided system comprising:

an implantable biomarker having a dielectric base and a plurality of wave-guide rods, the plurality of wave-guide rods being disposed on a plane and extending from the dielectric base in a parallel orientation;

a means for mounting the implantable biomarker on the device;

a transducer adapted to emit an excitation signal and receive a return signal;

a computer adapted to interpret the return signal and determine the location of the implantable biomarker, the computer being operably connected to the transducer; and

a means for reporting the location of the implantable biomarker, the means for reporting being operably connected to the computer.

4. The image guided system of claim 3 wherein the dielectric base includes two opposing sides extending from the dielectric base, and each of the plurality of wave-guide rods extend from, in alternating order, one of the two opposing sides, such that each of the plurality of wave-guide rods overlaps those adjacent, between the two opposing sides.

5. The image guided system of claim 3 wherein the device to be tracked is a surgical instrument, and the means for mounting is a mounting collar adapted to be attached adjacent an operative tip of the surgical instrument.

6. The image guided system of claim 3 wherein the device to be tracked is a surgical implant, and the means for mounting is provided by directly bonding the dielectric base to the surgical implant.

7. An image guided system for tracking a surgical instrument in a mammalian body, the image guided system comprising:

an implantable biomarker having a dielectric base and a plurality of wave-guide rods;

a means for mounting the implantable biomarker on the surgical instrument adjacent an operative tip of the surgical instrument;

a transducer adapted to emit an excitation signal and receive a return signal;

a computer operably connected to the transducer,

the computer having a means for interpreting the return signal and determining the location of the implantable biomarker,

the computer also having a means for extrapolating the location of the surgical instrument based upon the location of the implantable biomarker; and

a means for reporting the location of the surgical instrument, the means for reporting being operably connected to the computer.

8. The image guided system of claim 7 wherein the dielectric base includes two opposing sides extending from the dielectric base, and each of the plurality of wave-guide rods extend from, in alternating order, one of the two opposing sides, such that each of the plurality of wave-guide rods overlaps those adjacent, between the two opposing sides, and are disposed on a plane and in a parallel orientation.

9. The image guided system of claim 7 wherein the means for mounting is a mounting collar adapted to be attached adjacent the operative tip of the surgical instrument.

10. An image guided system comprising:

a surgical implant;

an implantable biomarker operably mounted on the surgical implant, the implantable biomarker having a dielectric base and a plurality of wave-guide rods;

a transducer adapted to emit an excitation signal and receive a return signal;

a computer operably connected to the transducer,

the computer having a means for interpreting the return signal from the transducer and determining the location of the implantable biomarker; and

a means for reporting the location of the surgical implant, the means for reporting being operably connected to the computer.

11. The image guided system of claim 10 wherein the dielectric base includes two opposing sides extending from the dielectric base, and each of the plurality of wave-guide rods extend from, in alternating order, one of the two opposing sides, such that each of the plurality of wave-guide rods overlaps those adjacent, between the two opposing sides, and are disposed on a plane and in a parallel orientation.

12. The image guided system of claim 10 wherein the surgical implant includes a screw-receiving aperture, and the implantable biomarker is operably mounted adjacent or within the screw-receiving aperture.

13. The image guided system of claim 12 wherein the implantable biomarker is mounted on a carrier coil that is shaped to fit within the screw-receiving aperture.

14. The image guided system of claim 12 further comprising a drill guide shaped to operably engage a power drill, wherein the transducer and the computer are operably positioned within the drill guide so that when the power drill within the drill guide is properly positioned to drill through the screw-receiving aperture, the transducer and computer cooperate to trigger the means for reporting.

15. A method for tracking a surgical instrument during an operation on a mammalian body, the method comprising the steps of:

providing a surgical instrument having an implantable biomarker mounted adjacent an operative tip of the surgical instrument, the implantable biomarker having a dielectric base and a plurality of wave-guide rods;

providing a transducer adapted to emit an excitation signal and receive a return signal, the transducer being operably connected to a computer that includes a means for interpreting the return signal from the transducer and determining the location of the implantable biomarker, the computer also having a means for extrapolating the location of the surgical instrument based upon the location of the implantable biomarker, and the computer also having a means for reporting the location of the surgical instrument;

inserting the operative tip of the surgical instrument into the mammalian body; and

positioning the transducer for operatively transmitting the excitation signal into the mammalian body and receiving the return signal from the implantable biomarker.

16. The method of claim 15 further comprising the step of:

mounting the implantable biomarker on a mounting collar; and

mounting the mounting collar adjacent the operative tip of the surgical instrument.

17. The method of claim 15 wherein the dielectric base includes two opposing sides extending from the dielectric base, and each of the plurality of wave-guide rods extend from, in alternating order, one of the two opposing sides, such that each of the plurality of wave-guide rods overlaps those adjacent, between the two opposing sides, and are disposed on a plane and in a parallel orientation.

18. A method for tracking a surgical implant within a mammalian body, the method comprising the steps of:

providing a surgical implant having an implantable biomarker mounted thereon, the implantable biomarker having a dielectric base and a plurality of wave-guide rods;

providing a transducer adapted to emit an excitation signal and receive a return signal, the transducer being operably connected to a computer that includes a means for interpreting the return signal from the transducer and determining the location of the implantable biomarker and a means for reporting the location of the surgical implant;

inserting the surgical implant into the mammalian body; and

positioning the transducer for operatively transmitting the excitation signal into the mammalian body and receiving the return signal from the implantable biomarker.

19. The method of claim 18 wherein the dielectric base includes two opposing sides extending from the dielectric base, and each of the plurality of wave-guide rods extend from, in alternating order, one of the two opposing sides, such that each of the plurality of wave-guide rods overlaps those adjacent, between the two opposing sides, and are disposed on a plane and in a parallel orientation.

20. The method of claim 18 wherein the surgical implant includes a screw-receiving aperture, and the implantable biomarker is operably mounted adjacent or within the screw-receiving aperture.

21. The method of claim 20 wherein the implantable biomarker is mounted on a carrier coil that is shaped to fit within the screw-receiving aperture.

22. The method of claim 20 further comprising a drill guide shaped to operably engage a power drill, wherein the transducer and the computer are operably positioned within the drill guide so that when the power drill within the drill guide is properly positioned to drill through the screw-receiving aperture, the transducer and computer cooperate to trigger the means for reporting.