Apparatus and method for the optical imaging of tissue samples

• US 6,654,630 B2
• Filed: 05/31/2001
• Issued: 11/25/2003
• Est. Priority Date: 05/31/2001
• Status: Expired due to Term

• Current Assignee: Infraredx Incorporated (Nipro Corporation)
• Original Assignee: Infraredx Incorporated (Nipro Corporation)
• Inventors: Griffin, Mark A., Furnish, Simon M., Ryan, S. Eric, Zuluaga, Andres F., Tearney, Guillermo J., Tang, Jing, Bouma, Brett
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): Pass, Barry
• Application Number:
  US09/871,578
• Publication Number:
  US 20020183622A1
• Time in Patent Office: 908 Days
• Field of Search: 600/478, 600/477, 600/473, 600/476, 600/475, 600/407, 600/310, 600/109, 600/160, 600/182, 250/341, 250/462.1
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence

Abstract

A catheter based optical system for generating data as to the condition of a tissue sample of a mammalian vessel. The system includes an elongated catheter shaft having a tissue engaging distal end and a coupled proximal end and an elongated optical delivery fiber arrangement disposed through a lumen of said catheter, said optical delivery fiber arrangement having a distal end and a proximal end. The distal end of the delivery fiber arrangement has a re-director light emitter thereon for directing light against mammalian tissues. An elongated optical collection fiber arrangement is disposed through a lumen of the catheter, the optical collection fiber arrangement having a distal end and a proximal most end. The distal end of the collection fiber arrangement has a re-director light receiver thereon for receiving light reflected from the mammalian tissue by the light emitter. The light emitter and the light receiver are longitudinally spaced apart from one another in the distal end of the catheter. The catheter apparatus includes a light source in communication with the delivery fiber and a signal detector in communication with the receiving fiber for receiving and presenting data collected.

Claims

1. A system for spectroscopic analysis of tissue, the system comprising:

a catheter defining a lumen extending therethrough;

an optical delivery fiber arrangement extending through the lumen;

a delivery re-director disposed at a distal end of the delivery fiber arrangement for directing light from the delivery fiber arrangement against the tissue;

an optical collection fiber arrangement extending through the lumen;

a collection re-director disposed at a distal end of the collection fiber arrangement for receiving light from the tissue and directing the received light into the collection fiber arrangement, the collection re-director being separated from the delivery re-director.

2. The system of claim 1, further comprising

a light source in communication with the delivery fiber arrangement, and

a signal detector in communication with the collection fiber arrangement.

3. The system of claim 2, further comprising a rotary optical coupler arranged between the light source and the delivery fiber arrangement.

4. The system of claim 2, further comprising a rotary optical coupler arranged between the collection fiber arrangement and the signal detector.

5. The system of claim 2, further comprising a rotary optical coupler arranged to direct light into the delivery fiber arrangement and to receive light from the collection fiber arrangement.

6. The system of claim 5, wherein the rotary optical coupler comprises a beam splitter.

7. The system of claim 2, further comprising an acousto-optic modulator that selectively provides optical communication to one of the collection fiber arrangement and the delivery fiber arrangement.

8. The system of claim 1, wherein the delivery fiber arrangement and the collection fiber arrangement are configured to rotate about a common longitudinal axis within the catheter.

9. The system of claim 1, wherein the delivery fiber arrangement and the collection fiber arrangement have different diameters.

10. The system of claim 1 wherein the delivery fiber arrangement and the collection fiber arrangement form a coiled pair.

11. The system of claim 1, wherein the delivery fiber arrangement comprises a plurality of individual delivery fibers.

12. The system of claim 1, wherein the collection fiber arrangement comprises a plurality of individual collection fibers.

13. The system of claim 1 wherein the delivery fiber arrangement and the receiving fiber arrangement are co-axial with respect to one another.

14. The system of claim 13, further comprising a containing-cladding separating the delivery fiber arrangement and the collection fiber arrangement.

15. The system of claim 14, wherein the containing-cladding longitudinally encloses the delivery fiber arrangement and the collection fiber arrangement.

16. The system of claim 1, wherein the delivery re-director and the collection re-director are spaced apart from one another in a longitudinal direction.

17. The system of claim 1, wherein the delivery re-director and the collection re-director are spaced apart from one another in a radial direction.

18. A method for spectroscopic analysis of a sample of tissue within a vessel, the method comprising:

inserting a catheter into the vessel;

placing an optical delivery fiber arrangement through a lumen of the catheter, the optical delivery fiber arrangement having a distal end in optical communication with a delivery re-director for directing light toward the tissue;

arranging an optical collection fiber arrangement through the lumen, the optical collection fiber arrangement having a distal end in optical communication with a collection re-director for receiving light from the tissue, the collection re-director being spaced apart from the delivery re-director;

passing light into the delivery fiber arrangement; and

detecting a signal indicative of light received by the collection fiber arrangement.

19. The method of claim 18, further comprising rotating the collection fiber arrangement and the delivery fiber arrangement about a common axis within the catheter.

20. The method of claim 19, wherein passing light into the delivery fiber arrangement and detecting a signal indicative of light received by the collection fiber comprise connecting the collection fiber arrangement and the delivery fiber arrangement to an optical slip ring.

21. The method of claim 20, further comprising twisting the delivery fiber arrangement and the collection fiber arrangement into a coil about one another.

22. The method of claim 20, further comprising placing the collection fiber arrangement and the delivery fiber arrangement co-axial with one another.

23. The method of claim 20, further comprising selecting the collection and delivery re-directors to be angled fiber members arranged at the distal ends of the collection fiber arrangement and the delivery fiber arrangement respectively.

24. The method of claim 23, further comprising selecting the optical delivery fiber and the optical collection fiber to comprise a common fiber.

25. The method of claim 20, further comprising selecting the optical slip ring to include a rotating coupler in optical communication with the optical collection fiber arrangement and the optical deliver fiber arrangement.

26. The method of claim 20, further comprising selecting the optical slip ring to include an acousto-optical modulator to selectively provide optical communication to one of the deliver fiber arrangement and the collection fiber arrangement.

27. The method of claim 26, further comprising causing the acousto-optical modulator to split a source light beam into a pair of beams in a pair of optical fibers and to recombine a split beam into a common light beam for communication to a detector.

28. The method of claim 20, further comprising selecting the optical slip ring to include a rotatable polarizing beamsplitter in attached rotational conformance with the optical delivery fiber arrangement and the optical collection fiber arrangement.

29. The method of claim 28, further comprising selecting the rotatable polarizing beamsplitter to be in optical communication with a stationary polarizing beamsplitter for communication of a light beam to a signal detector.

30. The method of claim 20, further comprising selecting the delivered light beam and the collected light beam to be non co-linear.

31. A catheter based optical system for generating data indicative of the condition of tissue of a vessel, the system comprising:

a catheter defining a lumen;

an optical delivery fiber arrangement extending through the lumen and configured to rotate about a longitudinal axis of the catheter;

a delivery re-director in optical communication with the optical delivery fiber arrangement, the delivery re-director disposed at a distal end of the optical delivery fiber arrangement for directing light against the tissue;

an optical collection fiber arrangement extending through the lumen and configured to rotate about a longitudinal axis of the catheter, the optical collection fiber arrangement having a diameter that is different from a diameter of the optical delivery fiber arrangement;

a collection re-director in optical communication with the optical collection fiber arrangement, the collection re-director disposed at a distal end of the optical collection fiber arrangement for receiving light from the tissue;

the collection re-director and the delivery re-director being longitudinally spaced apart from one another;

a light source in communication with the delivery fiber arrangement;

a signal detector in communication with the collection fiber arrangement for receiving and presenting the data, and

a rotary optical coupler disposed between the light source and the delivery fiber arrangement.

32. The system of claim 31, wherein the rotary optical coupler is disposed between the collection fiber arrangement and the signal detector.

33. A method of generating data indicative of a condition of tissue, the method comprising:

inserting, into a catheter, an optical delivery fiber having a distal end coupled to a delivery re-director,

inserting, into the catheter, an optical collection fiber having a distal end coupled to a collection re-director separated from the delivery re-director;

attaching a rotary optical pickup to proximal ends of each of the fibers to provide optical communication therewith;

attaching a light source to the rotary optical pickup to provide optical communication between the light source and the delivery re-director;

inserting the catheter into a vessel;

energizing the light source to provide light through the delivery fiber to the delivery re-director and onto the tissue;

collecting light from the tissue into the collection re-director;

receiving the collected light through the rotary optical pickup; and

directing the received light into a signal detector for analysis of the tissue.

34. The method of claim 33, further comprising circumferentially scanning the vessel by rotating the delivery fiber and the collection fiber about a common axis.

35. The method of claim 33, further comprising spacing the collection and delivery re-directors apart by a longitudinal distance.

36. The method of claim 35, further comprising adjusting the longitudinal distance between the collection and delivery re-directors by an adjustment arrangement at the proximal end of the catheter.

37. The method of claim 33, further comprising spacing the collection and delivery re-directors apart by a radial distance.

38. The method of claim 33, further comprising positioning the delivery fiber and the collection fiber to be co-axial.

39. The method of claim 38, further comprising placing a containment layer between the delivery fiber and the collection fiber to prevent optical light exchange therebetween.