Mobile neurological signal data acquisition system and method

• US 6,654,633 B2
• Filed: 11/07/2001
• Issued: 11/25/2003
• Est. Priority Date: 11/07/2001
• Status: Expired due to Fees

• Current Assignee: Neuralynx, Inc.
• Original Assignee: Neuralynx, Inc.
• Inventors: Stengel, Keith A., Franks, Steve G. E.
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): Mallari, Patricia C.
• Application Number:
  US10/047,205
• Publication Number:
  US 20030088161A1
• Time in Patent Office: 748 Days
• Field of Search: 600/544-545, 600/300
• US Class Current: 600/544
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/384 Recording apparatus or displays specially adapted therefor
• CPC Class Codes: A61B 5/389 Electromyography [EMG]

Abstract

A mobile neurological data acquisition system. A multiplexing circuit is utilized to combined multiple electrical-neurological signal inputs (synaptic “spikes”, EEG, EKG, EMG). A programmable logic device is utilized to package the combined signal into a packet containing a header and a footer. An analog transmitter is utilized to modulate a RF signal with the packetized combined signal and broadcast it to an analog receiver, where it is demodulated. An analog-to-digital converter is used to convert the demodulated combined analog signal into a combined digital signal. A computer and software algorithms are used to demultiplex the combined digital signal into discrete digital representations of the original electrical-neurological signals. The discrete digital signals are sent to a printer or video display for human analysis or stored on digital media such as a hard disk, a floppy disk, a magnetic tape, or a CD-ROM.

Claims

1. A method for acquiring neurological signal data, comprising:

producing a plurality of analog electrical data signals corresponding to a respective plurality of neurological data signals;

combining said plurality of electrical data signals into a single combined analog data signal;

modulating a radio-frequency signal by said combined data signal and transmitting said modulated radio-frequency signal;

receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

demultiplexing said reproduced combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals;

formatting said combined analog data signal to produce sets of data acquired within a common time frame and adding a header at the beginning of each said set prior to modulation of said radio-frequency signal so as to add a header at the beginning of said combined data signal and so that every header following the first header is inverted from its predecessor, said header comprising signal calibration information.

2. A method for acquiring neurological signal data, comprising:

producing a plurality of analog electrical data signals corresponding to a respective plurality of neurological data signals;

combining said plurality of electrical data signals into a single combined analog data signal;

modulating a radio-frequency signal by said combined data signal and transmitting said modulated radio-frequency signal;

receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

demultiplexing said reproduced combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals; and

organizing said combined data signal into sequential data packets of alternating polarity and blocking any dc component thereof prior to modulating said radio-frequency signal.

3. A neurological signal data acquisition system, comprising:

a plurality of neurological signal acquisition circuits for producing a respective plurality of electrical data signals representative thereof;

a multiplexor for receiving said plurality of electrical data signals and combining them into a single combined data signal;

a radio-frequency transmitter for receiving said combined data signal and producing a radio-frequency signal modulated thereby;

a radio-frequency receiver for receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

a demultiplexor for receiving said combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals; and

a signal formatting circuit adapted to produce sets of data acquired within a common time frame and add a header at the beginning of each said set prior to modulation of said radio-frequency signal thereby, said header comprising amplitude signal calibration information.

4. The neurological signal data acquisition system of claim 3, wherein said calibration information also comprises dc offset calibration information.

5. A neurological signal data acquisition system, comprising:

a plurality of neurological signal acquisition circuits for producing a respective plurality of electrical data signals representative thereof;

a multiplexor for receiving said plurality of electrical data signals and combining them into a single combined data signal;

a radio-frequency transmitter for receiving said combined data signal and producing a radio-frequency signal modulated thereby;

a radio-frequency receiver for receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

a demultiplexor for receiving said combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals; and

a signal formatting circuit adapted to produce sets of data acquired within a common time frame and add a header at the beginning of each said set prior to modulation of said radio-frequency signal thereby, said heater comprising amplitude signal calibration information, wherein every header following the first header is inverted from its predecessor.

6. A neurological signal data acquisition system, comprising:

a plurality of neurological signal acquisition circuits for producing a respective plurality of electrical data signals representative thereof;

a multiplexor for receiving said plurality of electrical data signals and combining them into a single combined data signal;

a radio-frequency transmitter for receiving said combined data signal and producing a radio-frequency signal modulated thereby;

a radio-frequency receiver for receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal; and

a demultiplexor for receiving said combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals, wherein said combined data signal is organized into sequential data packets of alternating polarity and is ac coupled from said multiplexor to said radio-frequency transmitter.

7. A compact neurological signal data acquisition assembly, comprising:

a plurality of neurological signal acquisition circuits, each corresponding to a corresponding distinct neurological signal input and being disposed on a respective, substantially-planar signal channel circuit board; and

a multiplexor circuit for receiving electrical signals from said plurality of neurological signal acquisition circuits and combining said electrical signals into a single combined signal;

a radio-frequency transmitter for receiving said combined data signal and producing a radio-frequency signal modulated thereby; and

a common circuit board, said multiplexor circuit and said radio-frequency transmitter being disposed on said common circuit board, said common circuit board being substantially planar and said signal channel circuit boards being supported by said common circuit board in substantially parallel relation to one another perpendicular to said common circuit board.

8. A neurological signal data acquisition system, comprising:

a plurality of neurological signal acquisition circuits for producing a respective plurality of electrical data signals representative thereof,

a multiplexor for receiving said plurality of electrical data signals and combining them into a single combined data signal;

a radio-frequency transmitter for receiving said combined data signal and producing a radio-frequency signal modulated thereby;

a radio-frequency receiver for receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

a demultiplexor for receiving said combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals, wherein said demultiplexor includes an analog-to-digital converter for converting said combined data signal to digital form and a digital processor for extracting from said combined data signal in digital form to said plurality of electrical data signals.

9. The neurological signal data acquisition system of claim 8, wherein said demultiplexor includes a frame signal generation and clock signal generation circuit.

10. A method for acquiring neurological signal data, comprising:

producing a plurality of analog electrical data signals corresponding to a respective plurality of neurological data signals;

combining said plurality of electrical data signals into a single combined analog data signal;

modulating a radio-frequency signal by said combined data signal and transmitting said modulated radio-frequency signal;

receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

demultiplexing said reproduced combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals; and

wherein said demultiplexing includes converting said combined data signal to digital form and extracting said plurality of electrical data signals from said combined data signal in digital form.

11. The method of claim 10, further comprising generating frame signals and generating clock signals to synchronize the received said plurality of electrical data signals with the transmitted said plurality of electrical data signals.

12. A method for acquiring neurological signal data, comprising:

producing a plurality of analog electrical data signals corresponding to a respective plurality of neurological data signals;

combining said plurality of electrical data signals into a single combined analog data signal;

modulating a radio-frequency signal by said combined data signal and transmitting said modulated radio-frequency signal;

receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

demultiplexing said reproduced combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals;

formatting said combined analog data signal to produce sets of data acquired within a common time frame and adding a header at the beginning of each said set prior to modulation of said radio-frequency signal so as to add a header at the beginning of said combined data signal, said header comprising signal calibration information; and

including amplitude calibration information in said header.

13. A method for acquiring neurological signal data, comprising:

producing a plurality of analog electrical data signals corresponding to a respective plurality of neurological data signals;

combining said plurality of electrical data signals into a single combined analog data signal;

modulating a radio-frequency signal by said combined data signal and transmitting said modulated radio-frequency signal;

receiving and demodulating said radio-frequency signal so as to reproduce said combined data signal;

demultiplexing said reproduced combined data signal and reproducing said plurality of electrical data signals representative of respective neurological signals;

formatting said combined analog data signal to produce sets of data acquired within a common time frame and adding a header at the beginning of each said set prior to modulation of said radio-frequency signal so as to add a header at the beginning of said combined data signal, said header comprising signal calibration information; and

including dc offset calibration information in said header.