Iontophoresis device

• US 6,654,635 B1
• Filed: 08/24/2000
• Issued: 11/25/2003
• Est. Priority Date: 02/25/1998
• Status: Expired due to Fees

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Higo, Naruhito, Kuribayashi, Mitsuru, Maeda, Hiroyuki, Koga, Nobuhiro
• Primary Examiner(s): JACYNA, J CASIMER
• Application Number:
  US09/622,050
• Time in Patent Office: 1,188 Days
• Field of Search: 604/20, 604/501
• US Class Current: 604/20
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

An iontophoresis device, which can ensure the long-term stability of drugs and which can be easily assembled when used, is provided. A donor electrode-printed portion (6) is placed on one side of a backing layer (4), and a reference electrode-printed portion (7) is placed on the other side. Both printed parts are connected to a current generating part (Ia) through a connector (Id). A drug support film (14) is joined to a drug-dissolving portion (11), and a cup-like shaped protective cover (12), which covers the drug support film (14), is removed before the device is used. The exposed drug support film (14) is attached to the skin of a user, and the device is driven by turning on a power supply of the current-generating portion (Ia).

Claims

1. An iontophoresis device in which a drug portion is brought into contact with a drug-dissolving portion upon practical use to thus administrate a drug supported by the drug portion, wherein the drug portion comprises a drug-support for supporting the drug and covers, which do not come in contact with the drug-support, for protecting both sides of the drug-support, and at least one of the drug-support and the covers is subjected to fabrication treatment for positioning.

2. The iontophoresis device according to claim 1 wherein at least one of the covers is molded and fabricated into a cup-like shape.

3. The iontophoresis device according to claim 1 wherein the drug-support is a porous polymer film.

4. The iontophoresis device according to claim 1, wherein the drug-support is obtained by applying a drug solution and then drying.

5. The iontophoresis device according to claim 1, wherein one of the covers has a hole for applying the drug solution.

6. The iontophoresis device according to claim 1, wherein at least one of the covers is coated with silicone.

7. The iontophoresis device according to claim 1, wherein an adhesive layer is arranged on the periphery of both of the sides of the drug-support.

8. The iontophoresis device according to claim 1, wherein it is further provided with an additional structure for positioning the drug portion and the drug-dissolving portion.

9. The iontophoresis device according to claim 8, wherein the additional structure is a hole for positioning, arranged on the periphery of at least one of the drug portion and the drug-dissolving portion.

10. The iontophoresis device according to claim 8, wherein the additional structure is a hole formed on a part of a release cover for the drug-dissolving portion and capable of being combined with the drug portion.

11. The iontophoresis device according to claim 8, wherein a concave or convex frame is formed on the periphery of the drug-dissolving portion and the cup portion is incorporated into the frame to perform the positioning of the drug-dissolving portion and the drug portion.

12. The iontophoresis device according to claim 8, wherein the periphery of the drug portion is molded and fabricated into a concave or convex shape, the drug-dissolving portion is provided with a concave or convex molded portion at the corresponding position and the concave and convex portions of the drug portion, and the drug-dissolving portion are combined together to thus perform the positioning of these portions.

13. The iontophoresis device according to claim 8, wherein the cup portion of the drug portion is molded and the positioning of the drug-dissolving portion and the drug portion is performed by pressing the cup portion from the top thereof.

14. A drug unit comprising a drug-support for supporting a drug and covers arranged on both sides of the drug-support while the covers do not come in contact with the drug support, said covers having a cup-like shape with an opening for applying a drug.

15. A kit for an iontophoresis device comprising an electrode portion provided with a drug-dissolving portion and a drug portion, which comprises a drug-support for supporting a drug and covers arranged on both sides of the drug-support while the covers do not come in contact with the drug-support, wherein the drug portion and the electrode portion are accommodated in separate packages.

16. The kit for an iontophoresis device according to claim 15, wherein the electrode portion and the drug portion are subjected to positioning treatments for laminating these portions.