Wet/dry automatic injector assembly

• US 6,656,150 B2
• Filed: 10/09/2001
• Issued: 12/02/2003
• Est. Priority Date: 10/10/2000
• Status: Expired due to Fees

• Current Assignee: Meridian Medical Technologies Incorporated
• Original Assignee: Meridian Medical Technologies Incorporated
• Inventors: Griffiths, Steven M, Hill, Robert L., Wilmot, John G.
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/972,201
• Publication Number:
  US 20020049406A1
• Time in Patent Office: 784 Days
• Field of Search: 604/82, 604/89, 604/191, 604/218, 604/236, 604/238, 604/187, 604/190, 604/90-92, 604/200-202, 604/87, 604/88
• US Class Current: 604/89
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3101 Leak prevention means for proximal end of syringes, i.e. syringe end opposite to needle mounting end
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/34 Constructions for connecting the needle , e.g. to syringe nozzle or needle hub connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 5/343 Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub A61M5/322 takes precedence

Abstract

The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The injection device includes a housing assembly, a dry compartment located within the housing for storing a predetermined dry charge of dry medicament therein, and a wet compartment located within the housing for storing a predetermined amount of liquid injection solution therein. The injection device further includes an activation assembly that enables the pressurization of the liquid injection solution in the wet compartment. The activation assembly also enables the compression of the dry medicament within the dry compartment upon activation of the automatic injection device. The activation assembly further facilitates passage of the liquid injection solution from the wet compartment to the dry compartment upon activation of the automatic injection device.

Claims

1. An automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof, said automatic injection device comprising:

a housing assembly;

a dry compartment located within the housing for storing a predetermined dry charge of dry medicament therein;

a wet compartment located within the housing for storing a predetermined amount of liquid injection solution therein;

an activation assembly for pressurizing the liquid injection solution in the wet compartment, wherein the activation assembly permits passage of the liquid injection solution from the wet compartment to the dry compartment upon activation of the automatic injection device; and

a needle assembly for dispensing the liquid injection solution containing the medicament dissolved therein, wherein the activation assembly includes a drive assembly, whereby upon actuation of the activation assembly, the drive assembly releases a stored source of energy for causing the liquid injection solution in the wet compartment to be transferred to the dry compartment and the liquid injection solution containing the medicament to be dispensed through the needle assembly.

2. The automatic injection device according to claim 1, wherein the activation assembly further compressing the dry medicament within the dry compartment upon activation of the automatic injection device.

3. The automatic injection device according to claim 1, wherein the activation assembly includes a first pressure element that applies pressure to the liquid injection solution within the wet compartment upon activation of the automatic injection device.

4. The automatic injection device according to claim 3, wherein the activation assembly further compressing the dry medicament within the dry compartment upon activation of the automatic injection device.

5. The automatic injection device according to claim 4, wherein the activation assembly includes a second pressure element that compresses the dry medicament within the dry compartment upon activation of the automatic injection device.

6. The automatic injection device according to claim 5, wherein the second pressure element provides a barrier between the wet compartment and the dry compartment to prevent the transfer of the liquid injection solution from the wet compartment to the dry compartment prior to activation of the automatic injection device.

7. The automatic injection device according to claim 5, wherein the activation assembly further includes a linking member for transmitting a force from the first pressure element to the second pressure element.

8. The automatic injection device according to claim 7, wherein the first pressure element selectively engages the linking member.

9. The automatic injection device according to claim 8, wherein the linking member is slidably received within an aperture within the first pressure element.

10. The automatic injection device according to claim 7, wherein the linking member is in contact with the second pressure element.

11. The automatic injection device according to claim 10, wherein the linking member extends through the wet compartment to engage the second pressure element.

12. A method of mixing a dry medicament with a liquid injection solution in an automatic injection device for administering a dosage of medicament to a user, wherein the automatic injection device includes a dry compartment for storing the dry medicament prior to mixing, a wet compartment for storing a supply of liquid injection solution prior to mixing, and a needle assembly for transferring a mixture of dissolved dry medicament and the liquid injection solution to a user, the method comprising:

activating the automatic injection device whereby the following automatically occurs;

pressurizing the liquid injection solution in the wet compartment;

compressing the dry medicament in the dry compartment;

opening a fluid path between the wet compartment and the dry compartment to permit the passage of the liquid injection solution from the wet compartment to the dry compartment;

dissolving the dry medicament in the liquid injection solution within the dry compartment; and

transferring the mixture of the dissolved dry medicament and the liquid injection solution through the needle assembly to the user.

13. The method according to claim 12, wherein pressurizing of the liquid injection solution in the wet compartment comprises applying a force on a first pressure element within the wet compartment.

14. The method according to claim 13, wherein compressing the dry medicament in the dry compartment comprises:

transferring a force from the first pressure element to a second pressure element; and

compressing the dry medicament with the second pressure element.

15. The method according to claim 14, wherein the opening of the fluid path between the wet compartment and the dry compartment comprises:

moving the second pressure element from a first position to permit the passage of the liquid injection solution from the wet compartment to the dry compartment around the second pressure element.